DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and stan

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001260871.1	Gene:	stan / 36125	FlyBaseID:	FBgn0024836	Length:	3648	Species:	Drosophila melanogaster

Alignment Length:	848	Identity:	216/848 - (25%)
Similarity:	343/848 - (40%)	Gaps:	182/848 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 TISLLIGIL-CPHHVQGADPKFDPTTRMRLVLVPADAQVNSVIYRLRATDE------EFDYPLTF 179
            |.:|.:.:| |..|    .|.|:  .......:...|.|.|.:..|||||:      |.:|.:
  Fly   447 TTTLQVNVLDCNDH----SPTFE--AEQFEASIREGATVGSTVITLRATDQDIGKNAEIEYGI-- 503

  Fly   180 EFVGDASASTVKVESLPCTKYNS---VCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSIT 241
            |.|.| .|...:.:.:|..:.:|   |......|.|  |....|...|:..|.....:.:.   |
  Fly   504 EAVTD-GAGLAQDQEMPIFRIDSRSGVISTRSSLDR--ETSDSYHLLVTAADLASAQSERR---T 562

  Fly   242 AT----------NFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIA--RKNPLFQKPVYLELWGS 294
            ||          |...|.   |..:...:.:|||...||| |..:|  |.....|        |:
  Fly   563 ATASVQVKVLDDNDNYPQ---FSERTYTVQVPEDQWGGTE-DNTVAHIRATDADQ--------GN 615

  Fly   295 PLFAIRQKIV--------SSETTEGTVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGME 351
            .. |||..|:        |.::..|.|.|:.|||:|....|.|.|.|.|.    |..||:.. .:
  Fly   616 NA-AIRYAIIGGNTQSQFSIDSMSGDVSLVKPLDYESVRSYRLVIRAQDG----GSPSRSNT-TQ 674

  Fly   352 IVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFF 416
            ::|.|.|..|..|.|.::.....:...:..|..|::|.|.|.|:|...|:.|.:...::.|.  .
  Fly   675 LLVNVIDANDNAPRFYTSQFQESVLENVPVGYNIIRVQAYDSDEGANAEITYSISERDDNFP--L 737

  Fly   417 DINETSGEIFLMRPLE-----DIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDR 476
            .::..:|.:..::||:     ..||          .|:|::..|    ||..||: .:...:.|.
  Fly   738 AVDPRTGWVQTIKPLDREEQGRFAF----------QVVAKDGGV----PPKSASS-SVVITVQDV 787

  Fly   477 TNSPPYFENDHYVSRVDENAPHGTALTFV---DPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISP 538
            .::.|.|...:|.:.|.|:.|.||.:|.|   ||      |:|:..:  :.:|..|..|.|.|:
  Fly   788 NDNDPAFNPKYYEANVGEDQPPGTPVTTVTATDP------DEDSRLH--YEITTGNTRGRFAIT- 843

  Fly   539 NVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYIN--DVNDNAPVFE 601
              ::...| ||.:..:  |||:|::.....:.|.:.|..::     ..||:||  |.|:.||:||
  Fly   844 --SQNGRG-LITIAQS--LDYKQEKRFLLTVAATDSGGRSD-----TATVHINITDANNFAPIFE 898

  Fly   602 QPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLN-TSLN---------LDAETGL 656
            ...||..:.|:...||.|:.|.|||.|.|:..::.|:     || .|:|         ::.:||.
  Fly   899 NAPYSASVFEDAPVGTTVLVVSATDSDVGVNAQITYS-----LNEESINGLGSPDPFSINPQTGA 958

  Fly   657 ITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDL 721
            |..:.   ..|||....|.|.|.|:|...........:.|.:.||||..|.|...||:..:..|.
  Fly   959 IVTNA---PLDRETTSGYLLTVTAKDGGNPSLSDTTDVEIGVTDVNDNAPAFKSPLYQASILEDA 1020

  Fly   722 MGFTTTAVIHAEDKDATAPNNEVRYEIINGNY-DNQFVLDKVTGELTVREKIHLRSKKNAKTRRR 785
            :..|:...:.|.|.| ...|..::|.:.:.:. |..||:|..:|.:                  |
  Fly  1021 LVGTSVIQVAASDPD-VGLNGRIKYLLSDRDIEDGSFVIDPTSGTI------------------R 1066

  Fly   786 RQAGSDDEDTDIFILTARAYDLGVPVRFSTTTIRV-------YPPESRKRSVKFVVPGHNPDKAK 843
            ...|.|.|...:|.|||.|.|.|.|...||..:::       .||......:...||.::|..:.
  Fly  1067 TNKGLDRESVAVFHLTAIAVDKGSPPLSSTVEVQIRLEDVNDSPPTFASDKITLYVPENSPVGSV 1131

  Fly   844 TEETLSALSGGKVYIHNIRPLSPDEP----------GAKDIPA----GNPGIKERSVVTATVI-Y 893
            .         |:::.|:     |||.          |..|..|    ..||.:...::|.|.: |
  Fly  1132 V---------GEIHAHD-----PDEGVNAVVHYSIIGGDDSNAFSLVTRPGSERAQLLTMTELDY 1182

  Fly   894 DSS 896
            :|:
  Fly  1183 EST 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	34/110 (31%)
		Cadherin_repeat	372..469	CDD:206637	22/101 (22%)
		Cadherin_repeat	487..596	CDD:206637	32/113 (28%)
		Cadherin_repeat	605..703	CDD:206637	31/107 (29%)
		Cadherin_repeat	728..820	CDD:206637	24/92 (26%)
stan	NP_001260871.1	Cadherin_repeat	364..460	CDD:206637	4/12 (33%)
		Cadherin_repeat	468..577	CDD:206637	27/116 (23%)
		Cadherin_repeat	585..685	CDD:206637	34/114 (30%)
		Cadherin_repeat	693..790	CDD:206637	23/113 (20%)
		Cadherin_repeat	799..891	CDD:206637	31/110 (28%)
		Cadherin_repeat	901..1003	CDD:206637	32/109 (29%)
		Cadherin_repeat	1012..1108	CDD:206637	27/114 (24%)
		Cadherin_repeat	1118..1216	CDD:206637	17/82 (21%)
		Cadherin_repeat	1235..1313	CDD:206637
		EGF_CA	1483..1518	CDD:238011
		LamG	1558..1734	CDD:238058
		EGF	1760..1789	CDD:278437
		Laminin_G_2	1826..1944	CDD:280389
		TNFRSF	<1963..2061	CDD:304602
		EGF_Lam	2095..2140	CDD:214543
		HRM	2144..2200	CDD:280888
		GAIN	2293..2458	CDD:293098
		GPS	2743..2802	CDD:295363
		7tm_4	2809..3028	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010