DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and Pcdhb7

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	XP_001055294.3	Gene:	Pcdhb7 / 291652	RGDID:	1309422	Length:	798	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	182/781 - (23%)
Similarity:	299/781 - (38%)	Gaps:	165/781 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 GAMTAYRLLTISLLIGILCPHHVQGADPKFDPTTRMRLVLVPADAQVNSVIYRLRATDEEFDYPL 177
            |:..|:....:.|..|.|.....:.....:    :.||:|   |.:...:|.|     |:.|...
  Rat    42 GSFVAHLAKDLGLGAGELAARSARVVSDDY----KQRLLL---DPETGDLILR-----EKLDREE 94

  Fly   178 TFEFVGDASASTVKVESLPCTKYNSVCQANIVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSITA 242
            ...||.            ||     |....:.|::   |.:|:..::.::|
  Rat    95 LCGFVD------------PC-----VLPFQVSLEK---PVQYFQGELLIQD-------------- 125

  Fly   243 TNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIAR-----KNPLFQKPVYLELWGSPLFAIRQK 302
               ...|...||....::.|||:::.||.|...:|:     .|.|.|..|..    :|.|    .
  Rat   126 ---INDHAPEFPEGEILLKIPENSQPGTLLPLNLAQDLDVGSNGLQQYTVST----NPHF----H 179

  Fly   303 IVSSETTEGTVFLLGP-------LDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIV-VIVQDV 359
            :::...:||..:   |       ||.|:||...||::|.|..:.|.      :|..:| :::.|:
  Rat   180 VLTRNNSEGKKY---PELVQDRALDREEQAELSLTLMALDGGSPPR------SGTALVQILIMDI 235

  Fly   360 QDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGE 424
            .|..|.|.::|...::|....|...||.|.|.|.|.||...|.|||...::.....|.||:.:||
  Rat   236 NDNAPEFVNSPYEVQVPESCPPDSPILTVLAWDADAGNFGSVSYGLFQASDEIKKTFSINKVTGE 300

  Fly   425 IFLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYV 489
            |.|.:.|:            ...:.:..||:...:...|:....:...:.|..::.|........
  Rat   301 IRLKKELD------------FEKIKSYHVKIEATDGGGLSGRGSVMIEVLDVNDNAPELTISSLT 353

  Fly   490 SRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNN-----NGTFEISPNVAERSAGFLI 549
            |.|.||||......|      ||.|.|:|:||....::..|     ..||:          .|..
  Rat   354 SSVPENAPETIISIF------RVGDRDSGENGKVVCSISENLPFLLKSTFK----------NFYT 402

  Fly   550 RVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMT 614
            .|.: |.||.|.:......|...:|| ...|:....:||.::|:|||||.|.|.:|::.:.||.:
  Rat   403 LVTE-SPLDRESRAEYNITITVSDLG-TPRLTTQHTITVQVSDINDNAPAFTQTSYTMFVHENNS 465

  Fly   615 AGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNK------HGFDREVMPE 673
            ....:..:.|||.|||....:.| ::|...|..|.|   |.||:::.:.      ...|.|.:..
  Rat   466 PALHIGTISATDSDSGSNAHITY-SLLPPQNPQLAL---TSLISINPDNGQLFALRALDYEAVQA 526

  Fly   674 YHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLY----------EFILTHDLMGFTTTA 728
            :..:|.|.|.......:|..:.:.::|.||..|..   ||          |.:......|:..|.
  Rat   527 FEFHVGASDGGSPALSSQALVRVVVLDDNDNAPFV---LYPLQNASAPFTELLPRAAEPGYLVTK 588

  Fly   729 VIHAEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDE 793
            |: |.|.| :..|..:.::::.......|:   |.|.             |.:.|..|.....|.
  Rat   589 VV-AVDAD-SGQNAWLSFQLLKATEPGLFI---VWGH-------------NGEVRTTRMLSERDV 635

  Fly   794 DTDIFILTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVPGHNPDKA-KTEETLSALSGGKVY 857
            .....:|..:  |.|.|.|..:.|:.|...:...:.. ..:|...||.| |.|:.|:      ||
  Rat   636 PKHRLLLLVK--DNGDPPRSVSVTLLVLLVDGFSQPY-ISLPEVAPDPAQKVEDALT------VY 691

  Fly   858 I 858
            :
  Rat   692 L 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	29/113 (26%)
		Cadherin_repeat	372..469	CDD:206637	25/96 (26%)
		Cadherin_repeat	487..596	CDD:206637	31/113 (27%)
		Cadherin_repeat	605..703	CDD:206637	24/103 (23%)
		Cadherin_repeat	728..820	CDD:206637	18/91 (20%)
Pcdhb7	XP_001055294.3	Cadherin_2	32..112	CDD:285466	19/98 (19%)
		Cadherin_repeat	140..238	CDD:206637	29/114 (25%)
		Cadherin_repeat	246..343	CDD:206637	27/108 (25%)
		Cadherin_repeat	355..447	CDD:206637	30/109 (28%)
		Cadherin_repeat	455..557	CDD:206637	25/105 (24%)
		Cadherin_repeat	571..652	CDD:206637	19/100 (19%)
		Cadherin_C_2	688..770	CDD:293101	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000