DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad86C and Cdhr2

DIOPT Version :9

Sequence 1:NP_001247033.1 Gene:Cad86C / 41302 FlyBaseID:FBgn0261053 Length:1949 Species:Drosophila melanogaster
Sequence 2:XP_214434.4 Gene:Cdhr2 / 291002 RGDID:1560576 Length:1310 Species:Rattus norvegicus


Alignment Length:1243 Identity:275/1243 - (22%)
Similarity:456/1243 - (36%) Gaps:333/1243 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 PKFDPTTRMRLVLVPADAQVNSVIYRLRATDEEFDYPLTFEFVG------DASASTVKVESLPCT 198
            |.|:  :.|.|||:|.|..|.:|::.|.|||.:.| .||:...|      ..:::|.:|:.:...
  Rat    24 PVFE--SNMTLVLLPEDLPVGAVVFWLVATDPDGD-QLTYGISGLHANYFSVTSNTGEVKLVSSL 85

  Fly   199 KYNSVCQANIVLQRRLEPGRYY----DFQVSVKDTKGGMTTQLCSITATNFTTPHDLIFPHKPGI 259
            .:.::....|.:.  :..|...    :.||.|:|........|    .|.|:|......|....:
  Rat    86 DFETLPSFRITIS--VNDGHNVQVTKEMQVIVEDRNDNAPVFL----NTEFSTSIKETLPVGSVV 144

  Fly   260 I-MIPEDAKRGTE--LDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLLGPLDF 321
            . ::.||...|:.  ::|.|.:..|....       ...||.|        ...|::.|...|.:
  Rat   145 FSVLAEDKDTGSSGLVEYFIEKVIPSTDN-------SKDLFRI--------LVNGSIVLNDTLSY 194

  Fly   322 -EKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILP---- 381
             .|.|.|.|.:.|.|:           .|:....:|  .|...|||.|...:.:  |.:.|    
  Rat   195 NNKSAFYQLELKACDS-----------GGLLNNTLV--TQCSQPVFVSISVIDE--PDLDPQFVR 244

  Fly   382 -------------GDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLED 433
                         |..:|.|.|.|.|||....|.|.:.:...|  .:|.| |..|.|.:..||:.
  Rat   245 EFYSASVSEDATLGTSVLAVEAVDSDKGVNYNVTYNITNSTRP--GWFCI-EKDGVITVCGPLDR 306

  Fly   434 IAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFEN------------- 485
            ...:.. .:.|.:.|.|.|.|....:..|..|| .:...:.|..:..|.|.|             
  Rat   307 EQLLLD-NEEVQIQVTATEEKPNIYQQEAKVST-WVTIKVTDVNDHKPEFYNCSLQNCTFSPQEA 369

  Fly   486 -DHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGT----FEISPNVAERSA 545
             |::...|||   |.:|...:|......||.|.|.||.|.|:|   |||    |.:||..|..|.
  Rat   370 QDNFTGYVDE---HASARISIDGLTMVAYDPDQGANGTFLLSL---NGTDAEAFNVSPERAAVSV 428

  Fly   546 GFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELP 610
            ...:.|:::.|:|||::..:|.|::|.: ..:.|.| :..||:::.::||:.|||.:..|.:.:|
  Rat   429 SVQVVVKNSEMVDYEKKTEMQVQVVATD-SVSGNYS-VATVTIHLRNINDHRPVFSKSLYELTVP 491

  Fly   611 ENMTAGTKVV-QVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHG--FDREVMP 672
            ||...|..|. .:.|||.|....|.:.|:.:.|.......::.::|.:||   |:|  .|||...
  Rat   492 ENSPTGFLVTDSIEATDLDGDEWGPITYSLLPGAGEDLFEVEPKSGNVTV---KNGTLLDREKQA 553

  Fly   673 EYHLYVEARDMDGEGNRAQVPLI-IKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKD 736
            .|:|.::|.|   .||::...:: |.|:||||..|:.......|:...|   ...:..|.|.|.|
  Rat   554 MYYLTMQATD---GGNQSTTTMLQITLLDVNDNPPVVRGSYNIFVPEED---GDVSVTIQAYDDD 612

  Fly   737 ATAPNN-EVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFIL 800
            ....|| .:.:.::.|:|...|.:|..||.|...|.:...:...|...|             .:|
  Rat   613 QPGTNNSRLLFSLLPGSYSQNFSIDPDTGLLRNLEPLDREAIDPALEGR-------------IVL 664

  Fly   801 TARAYDLGVP-------VRFSTTTIRVYPPESRKRSVKFV----VPG--------HNPDKAKTEE 846
            |....|.|.|       |..:...|....|...:.|.:|.    |||        .:.|:.....
  Rat   665 TVHVADCGEPSLSTDVNVTITVEDINDNLPIFNQSSYEFFVMERVPGALVGTVKAWDADQTAANN 729

  Fly   847 TLS-ALSG-------------------GKVYIHNIRPLSPDEPGAK----DIPAGNP---GIKER 884
            .:| :|||                   |.:::  :..:|.|....|    .:.|.||   |::..
  Rat   730 RISFSLSGTGANNFILQSIVLALGWAEGHLWL--LPDVSLDYETQKLFNLTVSAENPGPQGLEST 792

  Fly   885 SVVTATVI--------YDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQ--------- 932
            :.:|..|:        .|:.|:..|| :.:..|.|.....::.||. .|:.|..::         
  Rat   793 ANITVVVVDVNDEPPTLDAVSLQSIS-VAENGSEHGQVAQVIAQDV-DTNALLRIELVDVLCTKA 855

  Fly   933 ------------------TQYKAENKVLFWLLILLATLVA-----LTILILLLCCICSWCPLYGA 974
                              :.|..:::.:.:.:..|.|||.     .|.|         ....|.:
  Rat   856 GVDVGSVCHGWFSVDTNGSVYINQSEAIDYEVCHLVTLVVRAQDLATDL---------GFDAYSS 911

  Fly   975 ATKRIVNISRTEDDVH----------LVHREMANGKQTKSVQVAEWMGRRDAWSAEK-------- 1021
            ....::||....|:..          ::...:...:|..|||.      ||..|.:.        
  Rat   912 NGSLLINIKDKNDNTPYFLPNNQTFVIIPELVLPNQQVASVQA------RDEDSEDNGIIKFSIL 970

  Fly  1022 -----PPDTRTKPTRWEFHDGREQLDEDVGRGQDIG------------EGDRRHIQSAE------ 1063
                 |.|..|.|.: .|     ::.:.|..|...|            :|..:....|:      
  Rat   971 KADFVPKDGATNPVQ-VF-----RISQSVEAGLYTGSIELVTNLDSTLQGTYQVTVQAQDQPAMD 1029

  Fly  1064 --------------EQQRRVRIKHNRTAKDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDRE 1114
                          :|..|||::.: |:::|:..|....:..||                     
  Rat  1030 PALETQTTLNLFTVDQSYRVRLQFS-TSREDVGANMEEIKAALI--------------------- 1072

  Fly  1115 HITRTRVNRQEYARRKQYDSEVRHIDDDSMRRHEIDRGSDIDFNTAHNSLKSKRELFI-----KD 1174
            ..|||.|          |...:::|  |||.|..::...|..|..::.|..:..||.:     :|
  Rat  1073 QATRTSV----------YVVTIQNI--DSMARARVNSYMDAYFVFSNGSALTLTELNVMIRKDQD 1125

  Fly  1175 GNVEILQL 1182
            ...::|||
  Rat  1126 ALRQLLQL 1133

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad86CNP_001247033.1 Cadherin_repeat 260..361 CDD:206637 20/104 (19%)
Cadherin_repeat 372..469 CDD:206637 28/113 (25%)
Cadherin_repeat 487..596 CDD:206637 36/112 (32%)
Cadherin_repeat 605..703 CDD:206637 31/101 (31%)
Cadherin_repeat 728..820 CDD:206637 23/99 (23%)
Cdhr2XP_214434.4 Cadherin_repeat 33..121 CDD:206637 22/90 (24%)
Cadherin_repeat 129..237 CDD:206637 28/137 (20%)
Cadherin_repeat 247..350 CDD:206637 27/107 (25%)
Cadherin_repeat 373..477 CDD:206637 36/111 (32%)
Cadherin_repeat 486..583 CDD:206637 32/102 (31%)
Cadherin_repeat 590..692 CDD:206637 25/117 (21%)
Cadherin_repeat 700..804 CDD:206637 20/105 (19%)
Cadherin_repeat 816..925 CDD:206637 18/119 (15%)
Cadherin_repeat 936..1044 CDD:206637 17/119 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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