DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and Fat3

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	XP_011240845.1	Gene:	Fat3 / 270120	MGIID:	2444314	Length:	4611	Species:	Mus musculus

Alignment Length:	2081	Identity:	416/2081 - (19%)
Similarity:	707/2081 - (33%)	Gaps:	643/2081 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PKFDPTTRMRLVL--VPADAQVNSVIYRLRATDEEF--DYPLTFEFVGDASASTVKVESLPCTKY 200
            |.|:.:|...:::  :|    |.:.:.::||.|.::  :..:|:....|:....| :|:......
Mouse  2835 PVFETSTYETIIMEGMP----VGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKV-IEAFNIDSN 2894

  Fly   201 NSVCQANIVLQRRLEPGRYYDFQVSVKD-----TKGGMTTQLCSITATNFTTPHDLIFPHK---- 256
            .........|....:|.  :.|.|...|     :...|......:|..|...|   :|.|:
Mouse  2895 TGWISTLKDLDHETDPA--FSFFVVASDLGEAFSLSSMALVSVKVTDINDNAP---VFAHEVYRG 2954

  Fly   257 -------PGIIM-----IPEDAKR-GTELDYVIARKNPLFQKPVYLELWGSPLFAIRQKIVSSET 308
                   ||.::     :.:|... ..::.|.|...||..|            ||:  .:|.|
Mouse  2955 NVKESDPPGEVVAVLSTLDKDTSNINRQVSYHITGGNPRGQ------------FAL--GMVQS-- 3003

  Fly   309 TEGTVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVT 373
             |..|::..|||.|:|.:|.|.|.|:|...        :....:.|.|.||.|..||........
Mouse  3004 -EWKVYVKRPLDREEQDIYFLNITASDGLF--------VTQAMVEVTVSDVNDNSPVCDQVAYSA 3059

  Fly   374 KLPPGILPGDK-ILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLEDIAFI 437
            .||..| |.:| ||:|.|:|.|.|:..::||.|....|  ..|| ::..|||      |:.:|.:
Mouse  3060 SLPEDI-PSNKIILKVSAKDADIGSNGDIRYSLYGSGN--NEFF-LDPESGE------LKTLAVL 3114

  Fly   438 THVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTAL 502
            .....||...:.......||    ..:|:|.|  .|.|..::||.|.::||.:.|.||......|
Mouse  3115 DRERVPVYNLIARATDGGGR----FCSSSVLL--LLEDVNDNPPVFSSNHYTACVYENTATKALL 3173

  Fly   503 TFV---DPYV----PRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYE 560
            |.|   ||.|    ..||..:...:||||:                :.|:|.::.   ...||.|
Mouse  3174 TRVQAMDPDVGINRKVVYSLEDSASGVFSI----------------DSSSGVIVL---EQPLDRE 3219

  Fly   561 QQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLAT 625
            ||.|....:.|.:..|..:||:|.:||:.:.|:|||.||||:..|.|.:||:.:.||:|:.|.||
Mouse  3220 QQSSYNISVRATDQSPGQSLSSLASVTITVLDINDNPPVFERRDYLVTVPEDTSLGTQVLSVFAT 3284

  Fly   626 DPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRA 690
            ..|.|...::.|....|......:::.:||.|:|   ....|.|....::|.|||:|........
Mouse  3285 SKDIGTNAEITYLIRSGNEQGKFSINPKTGGISV---LEALDYETCRRFYLVVEAKDGGTPALST 3346

  Fly   691 QVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATAPNNEVRYEIINGNYDN 755
            ...:.|.|.||||..|.|.:|:|..:::.|.:...:..::.|||.| :.||.::|:.|:.|:.||
Mouse  3347 AATVSIDLTDVNDNPPRFSQDVYSAVISEDALEGDSVILLIAEDVD-SKPNGQIRFSIVGGDRDN 3410

  Fly   756 QFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTTTIRV 820
            :|.:|.:.|.:.|::|:.          |.|.:|        :.|..:|.|.|:|...||||:.:
Mouse  3411 EFAVDPILGLVKVKKKLD----------RERVSG--------YSLLIQAVDSGIPAMSSTTTVNI 3457

  Fly   821 YPPESRKRSVKFVVPGH----NPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKDIPAGNPG- 880
            ...:....|..|....:    ..:|......|..:...:...||..|.|      ..|.:||..
Mouse  3458 DISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFS------FSILSGNEDE 3516

  Fly   881 ---IKERSVVTATVIY---------------DSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDT 927
               :....::.:.|::               ||..       .|::||......::.:.|.. .|
Mouse  3517 EFMLDSHGILRSAVVFRHMESPEYLLCIQAKDSGK-------PQQVSHTYIRVRVIEESTHK-PT 3573

  Fly   928 LTPLQTQYKAENKVLFWLLILLATLVALTILILLLCCICSWCPLYGAATKRIVNISRTEDD---- 988
            ..||:              |.:.|:                                 |||
Mouse  3574 AIPLE--------------IFIVTM---------------------------------EDDFPGG 3591

  Fly   989 ----VHLVHREM-------ANGKQTKSVQVAEWMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLD 1042
                :|...::|       ...:|....:|....|:..|...   .|:..........|||.|:.
Mouse  3592 VIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGG---LDSGKYVLNVSVSDGRFQVP 3653

  Fly  1043 EDVGRGQDIGEGDRRHIQSA--EEQQRRVRIKHNRTAKDD-LHLNFHNSRTNLIND--------- 1095
            .||          ..|::..  |..|..|.|:....:.:| :.|:.|..|..|.|.
Mouse  3654 IDV----------VVHVEQLVHEMLQNTVTIRFEDVSPEDFVGLHMHGFRRILRNAVLTQKQDSL 3708

  Fly  1096 RDVYMEDVIENRDLAGDREHITRTRVNRQEYARR----KQYDSEVRHIDD--------------- 1141
            |.:.::.|:....|    :.:....::..|:.:.    ::..:..||:::
Mouse  3709 RIISIQPVVGTNQL----DMLFAVEMHSSEFYKPAYLIQKLSNARRHLENVMHIAAILEKNCSGL 3769

  Fly  1142 DSMRRHEIDRGSDIDFNTAHNSLKSKRELFIKDGNVEILQLMTRDKTRDGLNLDDDNIYVNV--- 1203
            |...:| .::|..:|.:.                      |||....|  ::......|.||
Mouse  3770 DCQEQH-CEQGLSLDSHA----------------------LMTYSTAR--ISFVCPRFYRNVRCT 3809

  Fly  1204 ---PLKPAGN---LSHPQLLMVDNTGKEILMRRFIEEQPDGKQIIRE---HYQI-VPGATYIQSM 1258
               .:.|..|   :..|....:...|.|...|.|:.:.|.||  :.|   |..: ..|.:||:..
Mouse  3810 CNGGVCPGSNDPCVEKPCPEDMQCVGYEASRRPFLCQCPPGK--LGECSGHTSLSFAGNSYIKYR 3872

  Fly  1259 PNEVQQGSTLKGDTFPLG-----KSGPNSIVYSQLEP-------EVKVIHTQPVQAGEGVSLDQQ 1311
            .:|     ..|.:.|.|.     ......|:|::..|       |.|:.......:|.|:.
Mouse  3873 LSE-----NSKEEDFKLALRLRTLQSNGIIMYTRANPCMILKIVEGKLWFQLDCGSGPGIL---- 3928

  Fly  1312 MQPAVSNQSLTHELEHSLKQQNALLRQILMEKEK------LENAYTQHEVA-LETQSLPGQSMA- 1368
               .:|::::.....||          :.:|..:      |:::|.:...| |..|:|...|..
Mouse  3929 ---GISSRAVNDGSWHS----------VFLELNRNFTSLALDDSYVERRRAPLYFQTLSTDSAIF 3980

  Fly  1369 ---------IGTQTDCDAGTQTEGFDGVLDPEI----SLAKPSRRRARSE--------------- 1405
                     :.:.||........||.|.||..:    .|...::|.:.:|
Mouse  3981 FGALVQADNVRSLTDTRVTQVLGGFQGCLDSVVLNHYELPLQNKRSSFAEVVGLTELKLGCVLYP 4045

  Fly  1406 ------------NDESMSEDGYE---YVRFNPPNSPEGVYWIKRRRTKKRPRQPRK-------RI 1448
                        :..|:...||:   ..:|...|....:       |...|...|.       ..
Mouse  4046 DACQRSPCLHGGSCSSLPSGGYQCSCLSQFTGTNCESEI-------TACFPNPCRNGGSCDPIGN 4103

  Fly  1449 VMVEEVKRKIRTPIKEEEEVQERKKRV------------------------------PPKKPLRE 1483
            ..|...|..: |.:..|::|.|.::..                              |...|..:
Mouse  4104 TFVCSCKAGL-TGVTCEDDVDECEREECENGGSCVNLFGSFFCNCTPGYVGQYCGLRPVVVPNIQ 4167

  Fly  1484 TKTS-------------------------ILRKQLSDESRKDQSRNG-------------ESQTG 1510
            ...|                         :.||::   .||:.|||.             ....|
Mouse  4168 AGHSYVGKEELIGIAVVLFVIFTLIVLFIVFRKKV---FRKNYSRNNITLVQDPATAALLHKSNG 4229

  Fly  1511 NRHRSESDSHNRDMFMEITDSMDELASPGSHSIRKIQVEKYYKHSDGDFDEDDTEYSIDSDGDEI 1575
            ...||......|:::.|:        .|....:|.:.....:: ||   ...:.:..:|..|.|
Mouse  4230 IPFRSLRAGDGRNVYQEV--------GPPQVPVRPMAYTPCFQ-SD---SRSNLDKGLDVLGGE- 4281

  Fly  1576 VIRTNYPSRAQENERYRRQERTYAEPENPVDRKRPARKS----SPTDSQPEAMPRLSRRDSSKR- 1635
                             .||.:...||:|  |...||:.    |...:.|...|..|..||.::
Mouse  4282 -----------------PQEMSTFHPESP--RILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKN 4327

  Fly  1636 ---------------------GSRKQTSSEPPHNRVSISKYESTVTENGR------KLMSTSTEI 1673
                                 .|.|.::||..    |:|.::|...::..      :|::...:.
Mouse  4328 GWDTGSENKGTEDTGEVTCFTNSNKGSNSEVQ----SLSSFQSDSGDDNASIVTVIQLVNNVVDS 4388

  Fly  1674 VGSKRSLTD------RSYQSETELAGLEHEERNVPKYMEWYYNKKKSSVSGRTSTESSKSQPSSK 1732
            :.::.|:.|      |:|..:|.               :|....:.|.:....:.||...
Mouse  4389 IENEVSVMDQGQNYNRAYHWDTS---------------DWMPGARLSDIEEMPNYESQDG----- 4433

  Fly  1733 KKVGAAEKRVSKTRITAQPKDVEEYDETGGRYKPEPAPRKSPPKGSRLLKEDRALNKQHKPKIET 1797
               |||.:        ...:::|.....||.......|   ||      .|:..|::...|.
Mouse  4434 ---GAAHQ--------GSTRELESDYYLGGYDIDSEYP---PP------HEEEFLSRDQLPP--- 4475

  Fly  1798 DTNHPLLQHSEHRFERENALEVPAAPTKLPHYMYPE------------TPPHAAAGGKESKSGRE 1850
                ||.:....::|   ||. |:.||.|...|.|:            .|||...|  |:..|..
Mouse  4476 ----PLPEDFPDQYE---ALP-PSQPTSLTSTMSPDCRRRPRFHPSQYLPPHPLPG--ETDLGGP 4530

  Fly  1851 SKT---------SKEAKPKPSPIRENEVKVSNSKIYVEHRGTGHPTQKQLNASTLEDDHDSGIAM 1906
            |.:         ..:.....:|.....:.:.||      |||   :..:::|....|  ||.:||
Mouse  4531 SSSCDFSTFAVNMNQGTEVMAPTDSVSLSLHNS------RGT---SSSEMSARCGFD--DSEVAM 4584

  Fly  1907 N 1907
            :
Mouse  4585 S 4585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	26/106 (25%)
		Cadherin_repeat	372..469	CDD:206637	29/97 (30%)
		Cadherin_repeat	487..596	CDD:206637	34/115 (30%)
		Cadherin_repeat	605..703	CDD:206637	29/97 (30%)
		Cadherin_repeat	728..820	CDD:206637	28/91 (31%)
Fat3	XP_011240845.1	Cadherin_repeat	47..153	CDD:206637
		Cadherin_repeat	162..262	CDD:206637
		CA	286..373	CDD:214520
		Cadherin_repeat	380..468	CDD:206637
		Cadherin_repeat	477..574	CDD:206637
		Cadherin_repeat	592..672	CDD:206637
		Cadherin_repeat	733..827	CDD:206637
		Cadherin_repeat	835..931	CDD:206637
		Cadherin_repeat	940..1018	CDD:206637
		Cadherin_repeat	1049..1144	CDD:206637
		Cadherin_repeat	1152..1250	CDD:206637
		Cadherin_repeat	1258..1348	CDD:206637
		Cadherin_repeat	1367..1479	CDD:206637
		Cadherin_repeat	1487..1585	CDD:206637
		Cadherin_repeat	1594..1684	CDD:206637
		Cadherin_repeat	1699..1788	CDD:206637
		Cadherin_repeat	1796..1902	CDD:206637
		Cadherin_repeat	1921..2000	CDD:206637
		Cadherin_repeat	2010..2103	CDD:206637
		Cadherin_repeat	2111..2202	CDD:206637
		Cadherin_repeat	2214..2306	CDD:206637
		Cadherin_repeat	2314..2413	CDD:206637
		Cadherin_repeat	2421..2513	CDD:206637
		Cadherin_repeat	2523..2619	CDD:206637
		Cadherin_repeat	2627..2722	CDD:206637
		Cadherin_repeat	2735..2833	CDD:206637
		Cadherin_repeat	2841..2943	CDD:206637	18/108 (17%)
		Cadherin_repeat	2951..3048	CDD:206637	28/121 (23%)
		Cadherin_repeat	3057..3150	CDD:206637	32/108 (30%)
		Cadherin_repeat	3158..3255	CDD:206637	34/115 (30%)
		Cadherin_repeat	3264..3360	CDD:206637	30/98 (31%)
		Cadherin_repeat	3368..3465	CDD:206637	30/115 (26%)
		Cadherin_repeat	3474..3565	CDD:206637	15/103 (15%)
		Cadherin_repeat	3584..3661	CDD:206637	17/122 (14%)
		Laminin_G_2	3888..4014	CDD:366983	25/142 (18%)
		EGF_CA	4046..4081	CDD:238011	5/34 (15%)
		EGF_CA	4080..4119	CDD:238011	6/46 (13%)
		EGF_CA	4121..4156	CDD:238011	2/34 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910