DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and PCDHGA12

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_003726.1	Gene:	PCDHGA12 / 26025	HGNCID:	8699	Length:	932	Species:	Homo sapiens

Alignment Length:	809	Identity:	181/809 - (22%)
Similarity:	311/809 - (38%)	Gaps:	187/809 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 CQAN--IVLQRRLEPGRYYDFQVSVKDTKGGMTTQLCSITATNFTTPHDLIFPHKPGIIMIPEDA 266
            ||.|  |:::.::   :.|..:|.|:|              .|...|:   |......|.|.|:|
Human   102 CQLNLDILMEDKV---KIYGVEVEVRD--------------INDNAPY---FRESELEIKISENA 146

  Fly   267 KRGTELDYVIAR-------KNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVF----LLGPLD 320
              .||:.:.:..       ||.|..    .||..:..|:    ::.....:|:.:    |...||
Human   147 --ATEMRFPLPHAWDPDIGKNSLQS----YELSPNTHFS----LIVQNGADGSKYPELVLKRALD 201

  Fly   321 FEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKI 385
            .|::|.:||.:.|:|     |.|........|.|:|.|..|..|.|........:|..:..|.::
Human   202 REEKAAHHLVLTASD-----GGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQL 261

  Fly   386 LQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPLE---------DIAFITHVG 441
            |.|:|.|.|:|...||||.....::.....|.::..||.|..:..|:         ::..:.:.|
Human   262 LVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAG 326

  Fly   442 DPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTFVD 506
            ......|:...:.|..:.|..:.:::                     .|.|.||:|.||.:..::
Human   327 YSARAKVLITVLDVNDNAPEVVLTSL---------------------ASSVPENSPRGTLIALLN 370

  Fly   507 PYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILA 571
                 |.|.|:.:||.. :..:..|..|::     |:|.|....:..:.:||.||..|....:.|
Human   371 -----VNDQDSEENGQV-ICFIQGNLPFKL-----EKSYGNYYSLVTDIVLDREQVPSYNITVTA 424

  Fly   572 QELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVR 636
            .:.| ...||...::::.:.|.|||.|||.|.:||..:|||...|..:|.|.|.|||.....::.
Human   425 TDRG-TPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQIT 488

  Fly   637 YT----AILG-YLNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGNRAQVPLII 696
            |:    .|.| .|::.::::::||::...::   ||.|...:..:.|.|||.......:.|.|.:
Human   489 YSLAENTIQGASLSSYVSINSDTGVLYALSS---FDYEQFRDLQVKVMARDNGHPPLSSNVSLSL 550

  Fly   697 KLIDVNDETPIFDKDLYEFILTHDLM-----------GFTTTAVIHAEDKDATAPNNEVRYEIIN 750
            .::|.||..|   :.||..:.|....           |:..|.|: |.|:| :..|..:.|.::.
Human   551 FVLDQNDNAP---EILYPALPTDGSTGVELAPRSAEPGYLVTKVV-AVDRD-SGQNAWLSYRLLK 610

  Fly   751 GNYDNQFVLDKVTGEL-TVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFS 814
            .:....|.:...|||: |.|..:                   |.|.....|.....|.|.|...:
Human   611 ASEPGLFSVGLHTGEVRTARALL-------------------DRDALKQSLVVAVQDHGQPPLSA 656

  Fly   815 TTTIRVYPPESRKRSVKFVVPGHNPDKAKTEE-------TLSALSGGKVYI-------------- 858
            |.|:.|...:|..:.:..:....:|..::|.:       .::|:|  .|::
Human   657 TVTLTVAVADSIPQVLADLGSLESPANSETSDLTLYLVVAVAAVS--CVFLAFVILLLALRLRRW 719

  Fly   859 HNIRPLSPDEPGAKDIPAGNPGIKERSVVTATVIYDSSSVVDISEIQ---QRLSHH-------NN 913
            |..|.|.....|....||                   |..|.:..:|   |..||.       ..
Human   720 HKSRLLQASGGGLTGAPA-------------------SHFVGVDGVQAFLQTYSHEVSLTTDSRK 765

  Fly   914 SYAIMPQDTSSTDTLTPLQTQYKAENKVL 942
            |:.|.|| .:..|.|...::..|:|..:|
Human   766 SHLIFPQ-PNYADMLVSQESFEKSEPLLL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	28/111 (25%)
		Cadherin_repeat	372..469	CDD:206637	21/105 (20%)
		Cadherin_repeat	487..596	CDD:206637	28/108 (26%)
		Cadherin_repeat	605..703	CDD:206637	28/102 (27%)
		Cadherin_repeat	728..820	CDD:206637	20/92 (22%)
PCDHGA12	NP_003726.1	Cadherin_2	30..112	CDD:285466	4/9 (44%)
		Cadherin_repeat	137..238	CDD:206637	28/115 (24%)
		Cadherin_repeat	246..343	CDD:206637	20/96 (21%)
		Cadherin_repeat	355..448	CDD:206637	27/104 (26%)
		Cadherin_repeat	456..558	CDD:206637	29/104 (28%)
		Cadherin_repeat	579..666	CDD:206637	23/107 (21%)
		Cadherin_C_2	688..772	CDD:293101	17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	803..841
		Cadherin_tail	809..>905	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	902..932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000