DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and Pcdhga9

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_001032235.1	Gene:	Pcdhga9 / 252895	RGDID:	620729	Length:	931	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	157/695 - (22%)
Similarity:	263/695 - (37%)	Gaps:	159/695 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 EGTV----FLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAP 370
            :||:    .|...||.|::..:||.:.|:|     |.|.|..:...|.|.|.|..|..|.|....
  Rat   187 DGTINPELVLERTLDREEEPSHHLVLTASD-----GGDPRRSSTALIQVTVLDTNDNAPAFDQPV 246

  Fly   371 PVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEIFLMRPL--ED 433
            ...|:...:.||..:|.|.|.|.|:|...:|.|.....|...:..|.::|.:||:.:.:.|  |:
  Rat   247 NRVKVLENVAPGTLLLTVRASDPDEGANGKVTYKFRKMNEKQSLLFHLHENTGEMTVAKTLDYEE 311

  Fly   434 IAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPH 498
            .:..              |:::..::...|....::...:.|..::.|........|.|.|:||.
  Rat   312 CSLY--------------EMEIQAEDGGGLKGRTKVVVTVEDVNDNRPEVTITSLFSPVREDAPP 362

  Fly   499 GTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQ 563
            ||.:...:     .:|.|:||||.. :..:..|.:|::     |.|.....|:....:||.|:..
  Rat   363 GTVIVLFN-----AHDQDSGKNGQV-VCSIQENPSFKL-----ENSVDDYYRLMTAQILDREKAS 416

  Fly   564 SVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPD 628
            .....:.|.:.| ..::|..|.:|:|:.|:|||.|.|.|.:|||.||||...||.:..|.|.|||
  Rat   417 EYNITVTATDRG-TPSMSTEVQITLYVADINDNPPAFSQTSYSVYLPENNPRGTSIFSVSAHDPD 480

  Fly   629 SGLGGKVRYTAILGY-----LNTSLNLDAETGLITVSTNKHGFDREVMPEYHLYVEARDMDGEGN 688
            .....||.|:.:...     |.:.::::::||::..   ...||.|......:.|:|.|......
  Rat   481 ENENAKVTYSLVENTIQGAPLTSYISINSDTGVLYA---LQSFDYEQFRNLQMQVKASDSGHPPL 542

  Fly   689 RAQVPLIIKLIDVNDETPIFDKDLYEFILTHDL-----------MGFTTTAVIHAEDKDATAPNN 742
            .:.|.|.:.|:|.||..|   |.||..:.|...           .|:..|.|: |.|:| :..|.
  Rat   543 SSNVSLSVFLLDQNDNAP---KILYPSLPTDGSTGVELAPRSAEAGYLVTKVV-AVDED-SGQNA 602

  Fly   743 EVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDL 807
            .:.|.::..:....|.:...:||:           :.|:....|.|....       |.....|.
  Rat   603 WLSYRLLKASEPGLFTVGLRSGEV-----------RTARALLERDALKQS-------LVVAVQDH 649

  Fly   808 GVPVRFSTTTIRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGA- 871
            |.|...:|.|:.|...:|        :|....|       ||::|         .|..||....
  Rat   650 GQPPLSATVTLTVAVADS--------IPDILAD-------LSSIS---------TPADPDSDITL 690

  Fly   872 ----------------------------------KDIPAGNPGIKERSVVTATVIYDSSSVVDIS 902
                                              :|...|:.|:            .:|.:|.:.
  Rat   691 YLVVAVAVVSCVFLLFVLVLLALRLRRWHASSLLQDAIGGSTGV------------PTSHIVGVH 743

  Fly   903 EIQQRLSHHNNSYAIMPQDTSS---------TDTLTPLQTQYKAE 938
            .:|..|..::..:::.|....|         .|||...::..|:|
  Rat   744 GVQTFLQTYSQEFSLTPDSGKSHLIFPQPNYADTLISQESCGKSE 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	17/54 (31%)
		Cadherin_repeat	372..469	CDD:206637	20/98 (20%)
		Cadherin_repeat	487..596	CDD:206637	29/108 (27%)
		Cadherin_repeat	605..703	CDD:206637	30/102 (29%)
		Cadherin_repeat	728..820	CDD:206637	18/91 (20%)
Pcdhga9	NP_001032235.1	Cadherin_2	30..112	CDD:285466
		Cadherin_repeat	139..238	CDD:206637	17/55 (31%)
		Cadherin_repeat	248..343	CDD:206637	21/108 (19%)
		Cadherin_repeat	356..448	CDD:206637	28/103 (27%)
		Cadherin_repeat	456..558	CDD:206637	31/104 (30%)
		Cadherin_repeat	579..666	CDD:206637	21/106 (20%)
		Cadherin_C_2	687..771	CDD:293101	9/95 (9%)
		Cadherin_tail	808..>904	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000