DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad86C and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	760	Identity:	223/760 - (29%)
Similarity:	333/760 - (43%)	Gaps:	104/760 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 ISLLIGILCPHHVQGADPKFDP----------TTRMRLVLVPADAQVNSVIYRLRATDEEFDYPL 177
            ::|::|:|   .:..|...|.|          ...|.|..:|.|..|.|.:|.|..||.|.| |:
Mouse     7 VALVLGLL---RIYLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGD-PI 67

  Fly   178 TFEFVGDASASTVKVESLPCTKYNSVCQ--ANIVLQRRLEPGRYYDFQ--VSVKDTKGGMTTQ-L 237
            ::....|.|..:|          .||..  .||.|...|:..|..:.:  :|:.|....:..: :
Mouse    68 SYHISFDPSTRSV----------FSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVAEKVV 122

  Fly   238 CSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIARKNPLFQKPVYLELWGSPLFAIRQK 302
            ..:|..|...|.   |..:|.||.:||:...|:.:..|.|.......       .||..::: |.
Mouse   123 ILVTDANDEAPR---FIQEPYIIRVPENIPAGSSIFKVQAEDKDTGS-------GGSVTYSL-QN 176

  Fly   303 IVSSETT----EGTVFLL--GPLDFEKQAMYHLTILANDAYAE-PGQDSRNIAGMEIVVIVQDVQ 360
            :.||:.:    .|.:.|.  ..||:||...:::|::|.|.... .|.|....|...:.:.|:|||
Mouse   177 LHSSKFSMDRHSGVLRLQAGATLDYEKSRAHYITVIAKDGGGRLRGADMVFSATTTVTINVEDVQ 241

  Fly   361 DQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGEI 425
            |..|:|...|....:....|||.::|.|.|.|||:|.|..:.|.|::|::   ..|:||||||.|
Mouse   242 DTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNESD---GIFEINETSGAI 303

  Fly   426 FLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDE-----PPALASTVQLAFFLPDRTNSPPYF-- 483
            .:::            .|.||.....|:.|...|     .||..:||.:...:.|..|.||.|
Mouse   304 SVLQ------------SPALLRREVYELHVQVTEVNSPGSPAAQATVPVTIRIVDLNNHPPTFYG 356

  Fly   484 ----ENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNNGTFEISPNVAERS 544
                :|...:| :.|:.|.|..|..:.   ..|.|.|.|.|..|:|.|:...|.|.:.|......
Mouse   357 ESGPQNKFELS-MFEHPPQGEILRGLK---ITVNDSDQGANAKFNLRLVGPGGIFRVVPQTVLNE 417

  Fly   545 AGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVEL 609
            |...|.|.:::.:|:|:.:.:.|::||.|:......|:..::.:.:.|.|||.|.|....|...:
Mouse   418 AQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYYIARI 482

  Fly   610 PENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKHGFDREVMPEY 674
            |||...|:.||.|.|.|||:|..|||.| :|.|..:....:...|||| .:......|.|....|
Mouse   483 PENAPGGSNVVAVTAVDPDTGPWGKVHY-SIYGTGSDLFLIHPSTGLI-YTQPWASLDAEGTSRY 545

  Fly   675 HLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAEDKDATA 739
            :.||:|.||||..:.|:|  .:.|:||||..|.|.:.:.|     ..|...|...|.|.|:||..
Mouse   546 NFYVKAEDMDGRYSLAEV--FVTLLDVNDHYPQFVQSVQE-----KTMVLGTPLKIEATDQDAEE 603

  Fly   740 PNNEVRYEIINGNYDNQFVLDKVTGELTVREKIH-LRSKKNAKTRRRRQAGSDDEDTDIFILTAR 803
            |||.|.|.|......|.|.:|..|||:.::..|. |.:..|.       ..|.|..   :.|..:
Mouse   604 PNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIRSLEALHNI-------TPSGDYS---WSLQVQ 658

  Fly   804 AYDLGVPVRFSTTT---IRVYPPE--SRKRSVKFVV-PGHNPDKA 842
            |.|.|.| .||||.   |.:...|  ||.....|:: ...||.||
Mouse   659 AKDRGSP-SFSTTALLKIDITDTERLSRGSMAAFLIQTKDNPMKA 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	26/107 (24%)
		Cadherin_repeat	372..469	CDD:206637	32/101 (32%)
		Cadherin_repeat	487..596	CDD:206637	28/108 (26%)
		Cadherin_repeat	605..703	CDD:206637	38/97 (39%)
		Cadherin_repeat	728..820	CDD:206637	32/95 (34%)
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	24/98 (24%)
		Cadherin_repeat	139..242	CDD:206637	28/110 (25%)
		Cadherin_repeat	251..350	CDD:206637	34/113 (30%)
		Cadherin_repeat	364..469	CDD:206637	28/108 (26%)
		Cadherin_repeat	478..573	CDD:206637	39/98 (40%)
		Cadherin_repeat	580..679	CDD:206637	35/114 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870