DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and Pcdha4

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	NP_031792.1	Gene:	Pcdha4 / 12936	MGIID:	1298406	Length:	947	Species:	Mus musculus

Alignment Length:	1087	Identity:	231/1087 - (21%)
Similarity:	382/1087 - (35%)	Gaps:	327/1087 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 IPEDAKRGT-----------ELDYVIARKNPLFQKPVYLELWGSPLFAIRQK----IVSSETTEG 311
            |||:||.||           ||..::.|                 ||.:..|    ::......|
Mouse    35 IPEEAKHGTFVGRIAQDLGLELTELVPR-----------------LFRVASKDRGDLLEVNLQNG 82

  Fly   312 TVFLLGPLDFEK------QAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVF---- 366
            .:|:...:|.|:      :...||.::.:          |.:....:.|.|:|:.|.||.|
Mouse    83 ILFVNSRIDREELCGRSAECSIHLEVIVD----------RPLQVFHVEVEVRDINDNPPRFPTTQ 137

  Fly   367 ------TSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETSGE- 424
                  .|.|..|..|   |.|       |.|.|.|....:.|.| |.|:    :|.:.:.|.:
Mouse   138 KNLFIAESRPLDTWFP---LEG-------ASDADIGINAVLTYRL-SPND----YFSLEKPSNDE 187

  Fly   425 ------IFLMRPLEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYF 483
                  :.|.:.|:.    ....:.:|:..:.:..|      |.|..:|||...:.|..::.|.|
Mouse   188 RVKGLGLVLRKSLDR----EETPEIILVLTVTDGGK------PELTGSVQLLITVLDANDNAPVF 242

  Fly   484 ENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKNG--VFSLTLLNNNGTFEISPNVAER--- 543
            :...|..::.||.|:||.:..|:     ..|.|.|.||  ::|.:.       :|||||..:
Mouse   243 DRSLYTVKLPENVPNGTLVVKVN-----ASDLDEGVNGDIMYSFST-------DISPNVKYKFHI 295

  Fly   544 ---SAGFLIRVRDNSMLDYEQQQSVQFQILAQELGPATNLSALVNVTVYINDVNDNAPVFEQPAY 605
               |...:::    ..:|:|:.:|.:..|...:.|... ||....|.|.:.|:|||.|..|..:.
Mouse   296 DPVSGEIIVK----GYIDFEECKSYEILIEGIDKGQLP-LSGHCKVIVQVEDINDNVPELEFKSL 355

  Fly   606 SVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAETGLITVSTNKH------ 664
            |:.:.||...||.:..:..:|.|:|:.|:|           :.:|.:......|||.|:
Mouse   356 SLPIRENSPVGTVIALISVSDRDTGVNGQV-----------TCSLTSHVPFKLVSTFKNYYSLVL 409

  Fly   665 --GFDREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYE-FILTHDLMG--- 723
              ..|||...:|.:.|.|||.......|...:.:::.||||..|:|.:..|. |:..::..|
Mouse   410 DSALDRETTADYKVVVTARDGGSPSLWATASVSVEVADVNDNAPVFAQPEYTVFVKENNPPGAHI 474

  Fly   724 FTTTAVIHAEDKDATAPNNE-VRYEIINGNYDNQFVLDKVTGE--LTVREKIHLRSKKNAKTRRR 785
            ||.:|:      ||.|..|. |.|.::          ::..||  |:....:|..|.|....:
Mouse   475 FTVSAM------DADAQENALVSYSLV----------ERRVGERLLSSYVSVHAESGKVFALQ-- 521

  Fly   786 RQAGSDDEDTDIFILTARAYDLGVPVRFSTTTIRVYPPESRKRSVKFVVP--------------- 835
               ..|.|:.::......|.|.|||...|..|::|:..:....:...:.|
Mouse   522 ---PLDHEELELLRFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLEPEAGVSGGIVSRLVSR 583

  Fly   836 ----GHNPDKAKTEETLSALSGGKVYIH--------NIRPL-----------------SPDEPG- 870
                ||...|.:   .:.|.||...::.        |.|.|                 ..|.|.
Mouse   584 SVGAGHVVAKVR---AVDADSGYNAWLSYELQSSEGNSRSLFRVGLYTGEISTTRILDEADSPRQ 645

  Fly   871 -----AKDIPAGNPGIKERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTP 930
                 .||  .|:|.:    :|||||:.   |:|:...:.:..|..:.|  :...:.|..|
Mouse   646 RLLVLVKD--HGDPAM----IVTATVLV---SLVENGPVPKAPSRVSTS--VTHSEASLVD---- 695

  Fly   931 LQTQYKAENKVLFWLLILLATLVALTILILLL--CCICSWCPLYGAATKRIVNISRTEDDVHLVH 993
                      |..:|:|.:..:.:|.:|.|||  ...||..|
Mouse   696 ----------VNVYLIIAICAVSSLLVLTLLLYTALRCSTVP----------------------- 727

  Fly   994 REMANGK----QTKSVQVAEW----MGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDVGRGQD 1050
            .|...|.    ...|..|..|    ..|:...|.|.||.|..........|.|::.|:
Mouse   728 SESVCGPPKPVMVCSSAVGSWSYSQQRRQRVCSGEYPPKTDLMAFSPSLSDSRDREDQ------- 785

  Fly  1051 IGEGDRRHIQSAEEQQRRVR-----IKHNRTAKDDLHLNFHNSRTNLIN------DRDVYMEDVI 1104
                    :||||:...:.|     .:::.:.:..:|.:.|.....::.      |:........
Mouse   786 --------LQSAEDSSGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSA 842

  Fly  1105 ENRDLAGDREHITRTRVNRQ----EYARRKQYDSEVRHIDDD----------SMRR----HEIDR 1151
            .....||:........||..    :|.......|....:.|.          |:|:    ::||:
Mouse   843 TPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDK 907

  Fly  1152 GSDIDFNTAHNSLKSKRELFIKDGNVEILQLMTRDKTRDGLNLDDDN 1198
            ...|.|.....:.|.|::   |.||      .|::|...| |...||
Mouse   908 SDFITFGKKEETKKKKKK---KKGN------KTQEKKEKG-NSTTDN 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	23/119 (19%)
		Cadherin_repeat	372..469	CDD:206637	21/103 (20%)
		Cadherin_repeat	487..596	CDD:206637	30/116 (26%)
		Cadherin_repeat	605..703	CDD:206637	26/105 (25%)
		Cadherin_repeat	728..820	CDD:206637	22/94 (23%)
Pcdha4	NP_031792.1	Cadherin_2	30..111	CDD:285466	19/92 (21%)
		Cadherin_repeat	139..238	CDD:206637	26/123 (21%)
		Cadherin_repeat	247..346	CDD:206637	30/115 (26%)
		Cadherin_repeat	354..451	CDD:206637	27/107 (25%)
		Cadherin_repeat	459..561	CDD:206637	28/122 (23%)
		Cadherin_repeat	581..670	CDD:206637	21/100 (21%)
		6 X 4 AA repeats of P-X-X-P	734..891		27/171 (16%)
		Required for interaction with FYN. /evidence=ECO:0000269\|PubMed:9655502	738..947		44/232 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..805		12/58 (21%)
		Cadherin_tail	796..939	CDD:292596	25/152 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..853		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..947		17/64 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000