Protein Alignment Cad86C and CDH18

DIOPT Version :9

• Sequence 1: NP_001247033.1
• Gene: Cad86C / 41302
• FlyBaseID: FBgn0261053
• Length: 1949
• Species: Drosophila melanogaster
• Sequence 2: NP_001278885.1
• Gene: CDH18 / 1016
• HGNCID: 1757
• Length: 790
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 181/708 - (25%)
• Similarity: 284/708 - (40%)
• Gaps: 161/708 - (22%)

  Fly   311 GTVFLLG----------PLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPV 365
            ||:|::.          .||.|::..|.|...|.|.......:..:    |.::.|||:.|..|.
Human    98 GTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPES----EFIIKVQDINDNAPK 158

  Fly   366 FTSAPPVTKLPPGILPGDKILQVHAEDGDK---GNPREVRYGLVSENNPFTSFFDINETSGEIFL 427
            ||..|.:..:|.....|..:|||.|.|.|.   ||...|.|.:: :..|   :|.::..:|.|..
Human   159 FTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSIL-QGQP---YFSVDPKTGVIRT 219

  Fly   428 MRPLEDIAFITHVGDPVLLTVIAEEV--KVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVS 490
            .....|.....|..    :.:.|:::  :||     .|:.:..:...|.|..::||.|...||..
Human   220 ALHNMDREAREHYS----VVIQAKDMAGQVG-----GLSGSTTVNITLTDVNDNPPRFPQKHYQL 275

  Fly   491 RVDENAPHGTALTFVDPYVPRVYDDDTGKNGVFSLTLLNNN--GTFEISPNVAERSAGFLIRVRD 553
            .|.|:|..|:|:..:     :..|.|||.|...:.:::|.:  |.|.||.:...|.....::
Human   276 YVPESAQVGSAVGKI-----KANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLK--- 332

  Fly   554 NSMLDYEQQQSVQFQILA---------QELGPATNLSALVNVTVYINDVNDNAPVFEQPAYSVEL 609
             ..|:||:::|....|..         ..|||..:.:.|   .:.:.|| |..|:|..|:|.:|:
Human   333 -KPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATML---KIIVGDV-DEPPLFSMPSYLMEV 392

  Fly   610 PENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTSL------NLDAETGLITVSTNKHGFDR 668
            .||...||.|..|||.|||| ....|||     ::|.::      |:||.||  |:.|.| ..||
Human   393 YENAKIGTVVGTVLAQDPDS-TNSLVRY-----FINYNVEDDRFFNIDANTG--TIRTTK-VLDR 448

  Fly   669 EVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIHAE 733
            |..|.|::.|.|.::|.....:.|.:.|:::||||..|...:: |:.|:..:.........|.|.
Human   449 EETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELARE-YDIIVCENSKPGQVIHTISAT 512

  Fly   734 DKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKK----NAKTRRRRQAGSDDED 794
            |||          :..||...| |.||:   .|.|.....|:..:    :..|||||.:.:..
Human   513 DKD----------DFANGPRFN-FFLDE---RLPVNPNFTLKDNEDNTASILTRRRRFSRTVQ-- 561

  Fly   795 TDIFILTARAYDLGVP--VRFSTTTIRVYPPE--------------------------------- 824
             |::.|.....|.|:|  ...||.||||...|
Human   562 -DVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLI 625

  Fly   825 ---------SRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKDIPA-GNP 879
                     :.:||.|..:.....|..:...|.....||:           ::..|.||.| .||
Human   626 LLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGE-----------EDTEAFDITALRNP 679

  Fly   880 GIKE--------RSVVTATVIYDSSSV---VDISE-IQQRLSHHNNSYAIMPQDTSST 925
            ...|        |..|..|..:.:||.   :|:.| |:|||:..:...::.|.|:..|
Human   680 SAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQT 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	14/59 (24%)
		Cadherin_repeat	372..469	CDD:206637	22/101 (22%)
		Cadherin_repeat	487..596	CDD:206637	29/119 (24%)
		Cadherin_repeat	605..703	CDD:206637	38/103 (37%)
		Cadherin_repeat	728..820	CDD:206637	28/97 (29%)
CDH18	NP_001278885.1	CA	79..157	CDD:214520	15/62 (24%)
		Cadherin_repeat	163..264	CDD:206637	25/113 (22%)
		Cadherin_repeat	272..379	CDD:206637	29/119 (24%)
		Cadherin_repeat	387..484	CDD:206637	39/105 (37%)
		Cadherin_repeat	491..589	CDD:206637	31/115 (27%)
		Cadherin_C	637..783	CDD:307269	28/112 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7733
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950