DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad86C and LOC100006777

DIOPT Version :9

Sequence 1:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster
Sequence 2:	XP_021335004.1	Gene:	LOC100006777 / 100006777	-ID:	-	Length:	966	Species:	Danio rerio

Alignment Length:	1088	Identity:	220/1088 - (20%)
Similarity:	380/1088 - (34%)	Gaps:	284/1088 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 FTTPHDLIFPHKPGIIMIPEDAKRGTELDYVIARKNPLFQ--KPVYLE--LWGSPLFAIRQKIVS 305
            :|.|.:|  .|...:..|.||.  |.:.:.:..|:..:..  |..|||  |....|| :.::|..
Zfish    29 YTIPEEL--EHGAFVGNIAEDL--GLDTNKLSVRRFRIVSGAKRQYLEVNLENGVLF-VNERIDR 88

  Fly   306 SETTEGTVFLLGPLDFEKQAMYHLTILANDAYAEPGQDSRNIAGMEIVVIVQDVQDQPPVFTSAP 370
            .|..|...:          ..:||.::.        ::...:..:|:.:.  ||.|..|||..:.
Zfish    89 EELCEQNPY----------CSFHLQVVI--------ENPLELYRVEVEIF--DVNDNSPVFPWSE 133

  Fly   371 PVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLVSENNPFTSFFDINETS-----GEIFLMRP 430
            ....:.....||.:.....|:|.|..: ..:|..|:|.|..|.  .|:...|     .|:.|..|
Zfish   134 FNLDISESAAPGSRFPLESAQDLDVAD-NSLRSYLLSVNEHFV--LDVQTRSDGSKFAELILESP 195

  Fly   431 LEDIAFITHVGDPVLLTVIAEEVKVGRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDEN 495
            |:.....||:   ::||.:       ....|..:.|.|:...:.|..::.|.|:.:.|..|:.||
Zfish   196 LDREQQKTHL---MVLTAV-------DGGSPERSGTAQINITVLDANDNAPVFDQNFYKVRLAEN 250

  Fly   496 APHGTALTFVDPYVPRVYDDDTGKNGVFSLTL-----LNNNGTFEISPNVAERSAGFLIRVRDNS 555
            ||.||.:..::     ..|.|.|.||..:.:.     :.....|.:.....|      |:|:  .
Zfish   251 APRGTVVIKLN-----ATDLDEGPNGEITYSFSGHAPMRVRELFSVDSRTGE------IKVK--G 302

  Fly   556 MLDYEQQQSVQFQILAQELGP---ATNLSALVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGT 617
            ::|||:.:..:..:.|::.||   |.:...:||:.    |||||.|.....:.|..:.|:...||
Zfish   303 LIDYEKARMHEIYVQAKDKGPSAVAVHCKVMVNII----DVNDNLPEVILTSVSTPVQEDAPPGT 363

  Fly   618 KVVQVLATDPDSGLGGKVRYTAILGYLNTSLNLDAET----------------GLITVSTNKHGF 666
            .:..:...|.|||..|               |:|.|.                .|:|...    .
Zfish   364 VIAVISVMDKDSGENG---------------NVDCEIPHHVPFQLHSSFKNYYTLVTCDF----L 409

  Fly   667 DREVMPEYHLYVEARDMDGEGNRAQVPLIIKLIDVNDETPIFDKDLYEFILTHDLMGFTTTAVIH 731
            |||.:.||::.:.||||.......:..:::::.|:||..|.|.:..|...||.:.....:...|.
Zfish   410 DRESISEYNITLTARDMGSPPLFTRKTILVQVSDINDNAPRFKQPSYTVYLTENNAPGASICTIT 474

  Fly   732 AEDKDATAPNNEVRYEIINGNYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTD 796
            |:|.||. .|:.:.|.|:..:.....|...|:..........|||             .|.|...
Zfish   475 AQDADAD-QNSYLSYSILENDIHGMPVSTYVSINSDNGNIYALRS-------------FDHEQLR 525

  Fly   797 IFILTARAYDLGVPVRFSTTTIRVY--------------PPESRKRSV----KFVVPGH------ 837
            .|.:..:|.|.|.|...:..|:.|:              .||:...:|    ::|..|:
Zfish   526 NFQIVVQAEDAGFPPLRANVTVNVFVLDQNDNPPVIVSPMPENDTAAVVVVPRYVDAGYLVAKIT 590

  Fly   838 --NPDKAKT--------EETLSALSGGKVY---IHNIRPLSPDEPG-------AKDIPAGNPGIK 882
              :.|..:.        :.|.::|....:|   |..||.|..::|.       .||  .|.|.:.
Zfish   591 AMDADAGQNSRLFYEVLQATDASLFSVALYTGEIRTIRRLMDNDPRRHRLVVLVKD--NGQPPLS 653

  Fly   883 ERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVLFWLLI 947
                .||:::.   ||||.:                |:.:.....|. |...|:: |..|:.::.
Zfish   654 ----ATASIML---SVVDSA----------------PESSPDFGDLA-LSPHYRS-NLTLYLIVS 693

  Fly   948 LLATLVALTILILLLCCI--C----SWCPLYGAATKRIVNISRTEDDVHLVHREMANGKQTKSVQ 1006
            |.|......:.|::|..|  |    |.|..:            |:|....|.:     |...::.
Zfish   694 LGAVSFTFLVAIIVLASIKGCKDGNSCCGFH------------TKDSESEVIK-----KSNLNIH 741

  Fly  1007 VAEWMGRRDAWSAEKP------------PDTR------TKPTRWEFHDGREQLDEDVGRGQDIGE 1053
            ::....:||.::|..|            |::.      .||........|..:.|...:......
Zfish   742 ISPGSIKRDQFNANNPMGPNYCYKMCLTPESSKSDFMFLKPCSPTGTSSRNNIKEIENKTLTWSS 806

  Fly  1054 GDR-----------RHIQSAEEQQRRVRIKHNRTAKDDLHLNFHNSRT---NLINDRDVYMEDVI 1104
            |..           ...:.|...:...:.:.|.|.:.:..||  ..||   .||.|.|.|....:
Zfish   807 GSHSISTRNGTTSPNEFKQANRDRTLTKNQLNYTYRSNTPLN--TGRTLQRRLIQDSDNYSYTSV 869

  Fly  1105 ENRDLAGDREHITRTRVNRQEYARRKQYDSEVRHIDDDSMRRHEIDRGSDIDFNTAHNSLKSKRE 1169
            ......|:..|..:|......:..|    |..|:...:|:                |.|...:..
Zfish   870 PQYWTWGNHIHDFKTSPKAGGFPNR----SWTRYNQQESV----------------HPSADYQHN 914

  Fly  1170 LFI-------------KDGNVEILQLMTR--DKTRDGLNLDDDNIYVN 1202
            ::|             .:|::|:....:.  .|.:....|.:|.|..|
Zfish   915 VYIPGTPSTLCTLKLANNGDIEVYNSFSTFGKKKKPNNTLQEDAIITN 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	20/104 (19%)
		Cadherin_repeat	372..469	CDD:206637	22/101 (22%)
		Cadherin_repeat	487..596	CDD:206637	29/116 (25%)
		Cadherin_repeat	605..703	CDD:206637	24/113 (21%)
		Cadherin_repeat	728..820	CDD:206637	21/91 (23%)
LOC100006777	XP_021335004.1	Cadherin_2	26..108	CDD:311943	21/101 (21%)
		Cadherin_repeat	133..234	CDD:206637	24/113 (21%)
		Cadherin_repeat	243..342	CDD:206637	29/115 (25%)
		Cadherin_repeat	355..447	CDD:206637	24/110 (22%)
		Cadherin_repeat	455..557	CDD:206637	25/115 (22%)
		Cadherin_repeat	573..664	CDD:206637	20/99 (20%)
		Cadherin_C_2	685..781	CDD:318652	19/112 (17%)
		Cadherin_tail	<884..950	CDD:318236	11/85 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X20
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000