Protein Alignment TTLL15 and TTLL6

DIOPT Version :10

• Sequence 1: NP_650021.1
• Gene: TTLL15 / 41300
• FlyBaseID: FBgn0037838
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001124390.1
• Gene: TTLL6 / 284076
• HGNCID: 26664
• Length: 891
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 111/492 - (22%)
• Similarity: 207/492 - (42%)
• Gaps: 120/492 - (24%)

  Fly   100 KFGYKRVGVNDSWNLLWAHDYPFLSFANLKNLGQHQVVNHYPGCGYLTNKVDLCTTQLP------ 158
            ::|::..|.:|.|.|.|. ||. :|...:..:..:|.:||:||...:..| ||....:.
Human   127 QYGFREGGEDDDWTLYWT-DYS-VSLERVMEMKSYQKINHFPGMSEICRK-DLLARNMSRMLKMF 188

  Fly   159 -----FLPRAFRLPAEREEFLDYARENPQALFVQKHNE---------HRHIKVRAPADIAFGSND 209
                 |.||.:.|||:..:...|:|......::.|.:.         .|.:|...|.:      |
Human   189 PKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGE------D 247

  Fly   210 SFVQEFVQRPYLVDGHKFDIGVYVVITSVNPLRVYIYTGDVLFRYCPVKYHPFDAENVDKYIVGD 274
            ...|.::.:|:::||.|||:.:||::||.:|||:::| .:.|.|:....|.....:|:|...:
Human   248 MICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVY-NEGLARFATTSYSRPCTDNLDDICM-- 309

  Fly   275 DYLPTWEVPSLRKYYNRF-----GGSMR--TVFEAYVRDQGKDPAQIWPQVEH-IVRTTIAAKEK 331
             :|..:   |:.|:.:.|     .||.|  :.|.||:.|...:..|||..:|. |::|.|:|..
Human   310 -HLTNY---SINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHP- 369

  Fly   332 DIVNILRSYRTHNF-------------FDLMRFDLFIDEDLKVFLMEANMSPNLSSAHFKPNSLL 383
                |:|    ||:             |:::.||:.:|..||.:|:|.|.||:     |..:|.|
Human   370 ----IIR----HNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPS-----FSTDSRL 421

  Fly   384 YEQV----LYSVFNLVGIRPLTSTSGALLGESSEMITTDKNLSTDLNKCAAHDC----------- 433
            .::|    ||....|:.:...         :..:::..::.....|.:|.:.:.
Human   422 DKEVKDGLLYDTLVLINLESC---------DKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAV 477

  Fly   434 ----DKSCNKEECD---LCLQCLSGSEYK-------------MLQQAHQEH----LHRVDMKRIF 474
                .::..||.|.   |....|:..:|:             :..:|.:|:    :..:.:|| .
Human   478 QLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKR-E 541

  Fly   475 PKPIRDPMRFDVMAETANMSKKNAWMTRWFHNKCQFD 511
            .||.:...:.::..|:|....:...|..|...:.|.|
Human   542 KKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKD 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL15	NP_650021.1	TTL	134..395	CDD:397308	81/305 (27%)
TTLL6	NP_001124390.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..106
		TTL	154..441	CDD:397308	82/314 (26%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	420..499		11/87 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	546..584		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	607..636
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..711
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..820