Protein Alignment CG14692 and ESC1

DIOPT Version :9

• Sequence 1: NP_650019.6
• Gene: CG14692 / 41298
• FlyBaseID: FBgn0037836
• Length: 2851
• Species: Drosophila melanogaster
• Sequence 2: NP_013946.1
• Gene: ESC1 / 855259
• SGDID: S000004832
• Length: 1658
• Species: Saccharomyces cerevisiae
• Alignment Length: 1941
• Identity: 389/1941 - (20%)
• Similarity: 705/1941 - (36%)
• Gaps: 534/1941 - (27%)

  Fly   468 NKTSL-----DLETLSQ-VEVKAENKSKD-----------YKSASEDQLKS-NKSLDAEQETHVD 514
            ||..|     .|:.||. ::...::|.||           |:.|...|..: ::|:.:.:.:|:.
Yeast    13 NKLKLTTPRRKLKILSSLLDADEDSKMKDQHGYSRVHNDKYRVAKPTQHSTLHESISSRRSSHIH 77

  Fly   515 SKDKPLANDLDDAIKAEDS----SSDLLRENREEDSALHRNTEKKESE-DVQENIVESAIASSNN 574
            :|.  |..|...|:...||    ...:|....:||:...|:.|::... .:.::::.....:|
Yeast    78 NKS--LHEDSARALSWVDSLINRGKSILTTLEKEDALFERSLEEERQRFQLHDSLMNKYTGNS-- 138

  Fly   575 ARNVEKEDEIIPLPKIQ----NSKSQLQEISLKNKITPTVSIEIEHVEDILEDSSASPNDSKADD 635
                :....:|.|.|.|    .|.....||.|.:.|:..:        ...||.|:|..||..|:
Yeast   139 ----KSHQRLIDLRKSQYGTDTSFQNNDEIPLDSFISSPL--------PDAEDESSSNIDSDKDE 191

  Fly   636 LTEGISVTEEPKSIPNVEVDSLKSILINHNLEGCEQETSAE-------------TIVDINFEAAA 687
            ..||                 .:|::.:.:||..|.|.|.|             .:.|..:....
Yeast   192 DLEG-----------------KQSLIKDFDLENDEYELSEEEKNSDGQSSPSIMILSDEEYAEEG 239

  Fly   688 AKQDIDSNEMIQSSDTHEKIREKRSIEYEDNVQLNSDSQNVLIAESPIDQEQLKINNDQTLELDR 752
            |.||:.::|..:         |:..:|.::                 |.|||..:.|
Yeast   240 ALQDVSNDEYAE---------EEGQVERKN-----------------IGQEQANVEN-------- 270

  Fly   753 KPEIIPKVEDVPKTTPNTKDDEVSGS--TEKLEMNKEEPLD----------ETVELSNHEITLSK 805
                         .|..:..|...|.  :|.:||..|:.:|          :..|.:.|.:..||
Yeast   271 -------------ATQISSSDSSEGQNYSEGVEMELEDDIDVESDAEKDESQGAEGTEHSVDFSK 322

  Fly   806 VLKTVSEN-KQERMEDLPSEDKIVKDSTS------------SLAEDSKMPEAKKESKSID----- 852
            .::..::| |...:|...|::..|....|            |:.::|:..|::.||.|.:
Yeast   323 YMQPRTDNTKIPVIEKYESDEHKVHQRYSEDGAFDFGSVNISVDDESEDEESQAESYSANAENVY 387

  Fly   853 -----ELETTKEVLEDIIHSETDLSKQNIKENVEETDKPQSDDSPKELENLKDKIKMLTQEEVTP 912
                 ||: .||::|||..|:::      .::.:|:::...||...:::|.|.     |.|| |.
Yeast   388 HHNEHELD-DKELIEDIESSDSE------SQSAQESEQGSEDDFEYKMKNEKS-----TSEE-TE 439

  Fly   913 IEPESLETKGLLSTDKNDKNSLFSKTNSEENNNESQNVDDITEKTDLKNEKHLLASHISVTSSGI 977
            ...||.: :| .:.|...||    |...:||:.|.:. |||...:..||      .|.:...|..
Yeast   440 NTSESRD-QG-FAKDAYTKN----KVEQQENDEEPEK-DDIIRSSLDKN------FHGNNNKSEY 491

  Fly   978 DDNDIQNTAASAELSVIDGDISIRESETKHVENREEMASTNLDSDQVENM--KLEGEIGQLKTVF 1040
            .:|.::|..        |..|..||::...||. .::...:::||..|:.  .|.....:....|
Yeast   492 SENVLENET--------DPAIVERENQINDVEG-YDVTGKSVESDLHEHSPDNLYDLAARAMLQF 547

  Fly  1041 EQSEEKTSPTKSESL------HAEDRKISGKSKESLED-------AGDENRAVEEIIDITENDRS 1092
            :||.....|.|.|.:      |:....:||:|.:..|:       .|:.|..:       :.||.
Yeast   548 QQSRNSNCPQKEEQVSESYLGHSNGSNLSGRSLDESEEQIPLKDFTGENNNNL-------KTDRG 605

  Fly  1093 TL-----LENLPSSEKENSTSLDENPLPEKESTSLDEKPSSGTEKST--SLDEKSSSEKEKSTSL 1150
            .|     :|....|||:...|.::..:|....|:::.. |.|.|.|.  |||:..:.    |.:|
Yeast   606 DLSSSVEIEVEKVSEKKLDGSTEKELVPLSTDTTINNS-SLGNEDSIYYSLDDADAI----SENL 665

  Fly  1151 DEKPSSEKEKSTSLDETPSSEKENSTSLDEK-----PSPEKESTSLDEKPSSGTEKSTSLDEKSS 1210
            .:.|..|.:.:...:...|....:|||.::.     |..|..|..:::..:|..:     |.:..
Yeast   666 TDVPLMEIKTTPKYEVVISESVYSSTSYEDNTVAMPPQVEYTSPFMNDPFNSLND-----DYEKK 725

  Fly  1211 SEKEKSTSLDEKPSSEKEKS----TSLNERPSSEKENSTSLVENPSPEKESTSLDEKPSSGT-EK 1270
            .:..|||.....|:..|:.:    ..:.:...:.....|::.......|:.:.|||...:.| |.
Yeast   726 HDLLKSTLAALAPAFTKKDAEFVEAGVTKSCLTSTSGHTNIFHTSKETKQVSDLDESTENVTFEN 790

  Fly  1271 STSLDENPSSEKEKSTSLNERPSSEKENSTSQDEK---------------------PSSETEKST 1314
            ..:.|||.:..|......|   |::|....:.|||                     .:|..|::.
Yeast   791 ENTGDENKNQSKNFPGVAN---STDKSTEDNTDEKYFSAINYTNVTGDSSCEDIIETASNVEENL 852

  Fly  1315 SLDEKPSSEKEKSTSLDGKPSSEKEKSTSLD---ENPSSEKEKSTSLNERPSSEKENSTSLVENP 1376
            ...||..:|.|.|:..:....::....|.:.   ::|.:.:|.:.:.....:..|..::.|.::.
Yeast   853 RYCEKDMNEAEMSSGDECVKQNDDGSKTQISFSTDSPDNFQESNDNTEFSSTKYKVRNSDLEDDE 917

  Fly  1377 SPEKEST------SLDEKPSSGTEKSTSLDENPSSEK----------EKSTSLNERPSSEKENST 1425
            |.:||.|      .|||:.|..:.:....|..|.:::          :|.|.....|.:||.|..
Yeast   918 SLKKELTKAEVVDKLDEEESEDSYEQDYADPEPGNDEGSNENIVKGTKKDTLGIVEPENEKVNKV 982

  Fly  1426 SQDEKPSSEKEKSTLLDKNTDLMRDLIQVSQKVDEEMSKGK----------AAIAVVDLPDINK- 1479
            .::|........|::..:|.|:..|:|....:.:.|..:.|          |.|::::..|.|.
Yeast   983 HEEETLFEANVSSSVNVQNKDMHTDVINQEAQANYEAGERKYYIQNTDTEEAHISIIERIDENAI 1047

  Fly  1480 GESVNSPLEKKPSSQELEDIQAELSTDKETGEPYNLSAEKHSE-----SETSNKPNNTTSKEIEG 1539
            |.::..|..........|.:....:|..|..:....:...|.:     |::....::|..|.:||
Yeast  1048 GNNMEIPERSCVEKTHNEVLFERRATTIENTKALENNTNMHDQVSQACSDSDRDQDSTAEKNVEG 1112

  Fly  1540 EDSRDHTKVEPISKKTIETTDVVDVGLKGNDDPSKPGKTETAATKSVSPDIKDKDTLKLKPDDDS 1604
              |..|.....:|...||                           ||.|         |||:.|
Yeast  1113 --SAKHNLDIRVSSSEIE---------------------------SVEP---------LKPESD- 1138

  Fly  1605 PQKSEVITAELQLKSFKTPNDDGAWYDIYVEPKITAERDLFVPPAPIETKRPNSAKEVASVVEEP 1669
              :|.:.::.:::        .||                             ..|.|..||:
Yeast  1139 --RSNIFSSPIRV--------IGA-----------------------------VVKGVGKVVD-- 1162

  Fly  1670 MIISERTPSYYTPKEIVESVKPKPKNSVSFFVSFDSDD----GKPKYKIPKRFQSQSNKNAQKEV 1730
              ::|   |:....::::|               :|||    |.....|   |...::.:|...:
Yeast  1163 --VAE---SFVKKIDVMDS---------------ESDDNVDIGDYNQDI---FNKSNSTDASVNM 1204

  Fly  1731 KAIEATQSESDIDSNEEEIEIIEVSEGDPEYQQTGGTKLQT---------ILELDNENEMTYE-- 1784
            |::    |..:.||:|:|..|:            ||...:.         ::.:|......||
Yeast  1205 KSV----SSKERDSDEDEAVIL------------GGVTAEAHNDNGNNSRVINIDPTTNGAYEED 1253

  Fly  1785 ---FNSQGQGLELNLNESNVEKP-------------KSPTNSINEFETAYKTDILNITRSVEIIE 1833
               |..|.:..| ||::|  |:|             |..:.:..||:|.|.    :|| |..|..
Yeast  1254 SEVFRQQVKDKE-NLHKS--EEPLVEGLQSEQHFEKKDHSENEEEFDTIYG----DIT-SANIHS 1310

  Fly  1834 RAYKRFKNRSSLKSEPGNESDFENQNRAAIVIQKWVRNTLKQKAYDTQKSKQSLAARKIQRAYRR 1898
            .|....|.:..||    |.||.||.::..|...:..:|..:....:|.:.:.....:.:...|..
Yeast  1311 NAPDDIKRQQLLK----NLSDLENYSQRLIEDSRRGKNQEESDEVNTSRERDLTFEKSVNEKYAG 1371

  Fly  1899 YVEK--------AKQRTQKQEMAALIIQKAFIRYSHRIRTEPNKTQSLVNIELK--QNNAAFKIQ 1953
            .:|:        :.|..:.:|  .|.:.....|....:.:||.:.: |..:|::  ...||..
Yeast  1372 AIEEDTFSELDISIQHPEHEE--DLDLSNNQERSIEELNSEPEEAE-LYELEIEGPTETAASS-- 1431

  Fly  1954 RAYRRYLKLQSERHQDAGIPVKDDSVSLINSVKLPTEPEIVNKLNSNDEHKVNLIPIHN------ 2012
                   |:..:..|...||          |..||::|.      |:.|...:..|..|
Yeast  1432 -------KMNDDERQRGNIP----------STDLPSDPP------SDKEEVTDSYPYSNSENITA 1473

  Fly  2013 QKVADYPEIIKEVQPEEPNDVLREAETESNTILLSDLTEKHKETN--EMHKKGSQELASVSAEVE 2075
            :|.|.....:.|:..:.||:|..|...|.....|    |||.:||  .:....|:.|:|...:.|
Yeast  1474 EKSAPTSPEVYEIFSDTPNEVPMEINDEIPATTL----EKHDKTNVTSVLDDRSEHLSSHDVDNE 1534

  Fly  2076 KPMDAS---KLPTENRRDEKQVVETISPPINLTQLSAEPKRVKELKSDGFQEIENLSNANFNPKS 2137
             |.|.|   |: .|....|.|.|:.   |:.: ::..|.   :|:.|....|.:..|....|.||
Yeast  1535 -PHDNSINIKV-NEGEEPEHQAVDI---PVKV-EVKEEQ---EEMPSKSVLEEQKPSMELINDKS 1590

  Fly  2138 STKSPDEIDLQPLEQAQKLVEIEKPSEEMKTELTNLSQASPNHPLKDDLVEKSNAA 2193
            |.::.::      |:..:  |.:|...:.|:...|.:    :...|..:.|.|:||
Yeast  1591 SPENNND------EETNR--EKDKTKAKKKSRKRNYN----SRRRKRKITEGSSAA 1634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	72/366 (20%)
ESC1	NP_013946.1	2A1904	<175..442	CDD:273344	69/343 (20%)
		MDN1	<945..1502	CDD:227596	132/715 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000