DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and cracd

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	XP_021324183.1	Gene:	cracd / 570321	ZFINID:	ZDB-GENE-041210-321	Length:	1187	Species:	Danio rerio

Alignment Length:	1322	Identity:	268/1322 - (20%)
Similarity:	478/1322 - (36%)	Gaps:	299/1322 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 VDNKTSLDLETLSQVEVKAENKSKDYKSASEDQLKSNKSLDAEQETHVDSKDKPLANDLDDAIKA 530
            :|:|.: .||.|.:|.|....:.:........:....|....|.|...:..:....:..||....
Zfish     3 MDSKEA-QLEELVEVTVSQTTERRRQGKFQPFRRLFGKKKRREAERAFEGTELKPCHSTDDVCNG 66

  Fly   531 EDSSS----DLLRENR--------EEDSALHRNTEKKESEDV--QENIVESAIASSNNARNVEK- 580
            .||::    ..|||:.        .|...:..::||......  |||:       |:..||::|
Zfish    67 VDSANQENDQYLRESNTLGSRAFSHESVFIPEDSEKTHPGQTMSQENV-------SDKVRNIQKQ 124

  Fly   581 -------------------------EDEI--IPLPKIQNSKSQLQEISLKNKITPTVSIE-IEHV 617
                                     |:|:  .||..:...:::..|.|.|.|   :||.: ::|.
Zfish   125 IGHNIKFGQRPPSLRKSEGDEGSSDEEEVPQSPLRVLAQVENEPPETSAKEK---SVSHDTVQHR 186

  Fly   618 EDILEDSSASPNDSKADDLTEGISVTEEPKSIPNVEVDSLKSIL--------INHNLEGCEQETS 674
            ..:....:..|   ......|.|::...|:|:|.::..:.|..|        ::.......||..
Zfish   187 TPVKSPRTKRP---PPPGTIESINLDAVPQSVPRLDNTAAKHKLSVKPKNQRVSRKHRRFTQEFH 248

  Fly   675 AETIVDIN---------FEAA--------AAKQDIDSNEMIQSSDTHEKIREKRSI-EYEDNVQL 721
            .:...:|.         |:::        .:|:|.:..|..|....||:.:|...| :.|...:.
Zfish   249 EDDFSEIQEEFEKDEEVFDSSREDYGIIHGSKEDYEPTEKSQRQRFHEEEKEHLEIKKREQEEER 313

  Fly   722 NSDSQNVLIAESPIDQEQLKINNDQTLELDRKPEIIPKVEDVPKTTPNTKDDEVSGSTEKLEMNK 786
            ..:....:|.|..:::|:.:...::.|:         |||:..|    .:::|.....|:.|..:
Zfish   314 KMEKHRRMIEEQRLEEEKRRRQEEERLQ---------KVEEERK----QREEEERKKREEEERRR 365

  Fly   787 EEPLDETVELSNHEITLSKVLKTVSENKQERMEDLPSEDKIVKDSTSSLAEDSKMPEAKKESKSI 851
            ||   |...|.:             |.:::|.|                 |:.:|.:.::|.|..
Zfish   366 EE---EERRLRH-------------EEERKRQE-----------------EEERMKKEEEERKRA 397

  Fly   852 DELETTKEVLEDIIHSETDLSKQNIKENVEETDKPQSDDSPKELENLKDK-----------IKML 905
            :|....:|:|.:.:.    |.::..:|..|...|.:.:...:.::.|::|           .:..
Zfish   398 EEERRQQELLAERLR----LEEERKREQEERRRKEEEEAEKRRIQELQEKRLREEEHRIREEERC 458

  Fly   906 TQEEVTPIEPESLETKGLLSTDKNDKNSLFSKTNSEE----NNNESQNVDDITEKTDLKNEKHLL 966
            .|||......|..|.|..|..:|........|..:||    ...|.|.  ..|.|.. ..||.:|
Zfish   459 RQEEAERKRLEEEERKRQLQEEKAGSTDPEWKRKAEELRWREMEERQR--PFTFKVS-SGEKQIL 520

  Fly   967 ASHISVT----SSGIDDNDIQNTAASAELSVIDGDISIRESETKHVENR------EEMASTNLDS 1021
            ...:::|    ::|........|...|:.|...|..|...|.:.:|.:.      .::..|.::.
Zfish   521 FQKVNLTPVTPATGQQGETTAETWEGAKASSPGGPDSPTLSSSLYVPHTAILVTGAQLCGTAVNL 585

  Fly  1022 DQVENMKLEGEIGQLKTVFEQSEEK----TSPTKSESLHAEDRKISGKSKESLEDAGDENRAVEE 1082
            ||:::...:..:|       .||.|    |.|:||::  :.||| |||:|...|.:...:::...
Zfish   586 DQIKDTACKSLLG-------LSEGKKAMGTPPSKSKT--SPDRK-SGKTKSVFESSLSTDQSNAA 640

  Fly  1083 IIDITENDRSTLLENLPSSEKENSTSLDENPLPEKESTSLDEKPSSGTEKSTSLDEKSSSEKEKS 1147
            ::....:.||.:.:.....:....|.....|..|    .|:..|.|    .|:|.:..|:..:.|
Zfish   641 VLAEWASIRSKIFKGAEEGKYPEYTDQSRRPTSE----DLNTVPFS----HTNLRKTMSASAKFS 697

  Fly  1148 TSLDEKPSSEKEKSTSLDETPSSEKENSTSLDEKPSPEKESTSLDEK-PSSGTEKSTSLDEKSSS 1211
            .:...|..::..:::.:.......|..|...:..| .:||..||..| .|.|::.....||:...
Zfish   698 ITPARKKFADSNRNSEIFGQEEGVKTESAFTETSP-VQKELPSLGTKVQSRGSKLVRIADEECMF 761

  Fly  1212 EKEKSTSLDEKPSSEKEKSTSLNERPSSEKENSTSLVENPSPEKESTSLDEKPSSGTEKSTSLDE 1276
            .|:..:.|...|.         :..|.|::..|.|.:     :.||...|.|...|.:|:...||
Zfish   762 AKDLPSFLVPSPP---------HGSPKSQRSESGSPI-----QAESEDSDTKDEDGEQKAQGGDE 812

  Fly  1277 NPS----SEKEKSTSL---NERPSSEKENSTSQDEKPSSETEKSTSLDEKP--SSEKEKSTSLDG 1332
            .||    ..:..:.||   ||:.:.:|:...|..:.........|::|:..  |:..|||:.:
Zfish   813 QPSPFGIKLRRTNYSLRFHNEQSAEKKKKRYSAGDSFEGVPVPLTAIDQDSDNSTLSEKSSPI-- 875

  Fly  1333 KPSSEK-EKSTSLDENPSSEKEKSTSLNERPSSEKENSTSLVENPSPEKESTSLDEKPSSGTEKS 1396
            .|..|. |..|::  .||.|.....|.:..|.:..|......:.|..:|.:||  .|||.|....
Zfish   876 SPQQENIEFQTTV--APSKESRSKFSRSTLPLARTEGDNMSPKPPLYQKPATS--PKPSEGATPL 936

  Fly  1397 TSLDENPSSEKEKSTSLNERPSSEKENSTSQ--DEK-------PSSEKEKSTLLDKNTDLMRDLI 1452
            .|....| ..:....::::|....::.:|.|  |.|       ||
Zfish   937 LSPLPKP-GRRTSGDTISQRTGEAEQVATEQGSDHKGGVTASGPS-------------------- 980

  Fly  1453 QVSQKVDEEMSKGKAAIAVVDLPDINKGESVNSPLEK-KPSSQELEDIQAELSTDKETGEPY--- 1513
            |.|.:.:|::.:.|:....:.:|...|.:.....::| |||.|....:.:..|.|||||..:
Zfish   981 QKSGQGEEDVKEKKSFFPSISIPWREKTDRRTELIKKEKPSLQARHSLDSSRSQDKETGPLWITL 1045

  Fly  1514 NLSAEKHSESETSNKPNNTTSKE--IEGEDSRDHTKVEPISKKTIETTDVVDVGLKGNDDPSKPG 1576
            .|..:|....:..|:......:|  :..:.:||..     |..:..|.|      |||...|...
Zfish  1046 ALQKQKGFREQQQNREERRNQREAKLAEKQARDRE-----SAGSSPTED------KGNGSSSIIS 1099

  Fly  1577 KTETA------------------------ATKSVSPDIKD--------KDTLKLKPDDDSPQKSE 1609
            |.:||                        ...||:.:|.|        ||..|..|..|:.|.|
Zfish  1100 KHQTADENKRPDTLLARFERRDNLKKANTLPSSVTVEITDSTPSPPATKDVTKRFPPGDTTQVS- 1163

  Fly  1610 VITAELQLKSFKTPNDDGAWYD 1631
            ...|.|.|...|..    ||.|
Zfish  1164 TEPAWLALAKRKAK----AWSD 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	74/327 (23%)
cracd	XP_021324183.1	DUF4592	127..238	CDD:317644	19/116 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000