DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and RIF1

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	NP_060621.3	Gene:	RIF1 / 55183	HGNCID:	23207	Length:	2472	Species:	Homo sapiens

Alignment Length:	1842	Identity:	352/1842 - (19%)
Similarity:	717/1842 - (38%)	Gaps:	386/1842 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 IEYSKYS-SYEKSLKDKEHLAPATKVTCE-CGRVLSANRKDVENTASVYT-DNKLAEAD------ 179
            |::|.|: .|:..:|..:..:..:|...| .|::.|..:..|:...|.:| ..|.|.:|
Human   767 IDFSPYNIKYQPKVKSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIG 831

  Fly   180 ---QREFSSRISYIQSVVIIQRHFRRYLNERKIGRDKDKCNSVDYVAAILLIQRQVRRYLAKKRV 241
               ....||.:.:|....:|::.|........:..:..|.:.|..|.:.|  ..::.:.|. :.:
Human   832 NSITGIISSVLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCL--NNKLEKLLG-EII 893

  Fly   242 AELKNSRDAQKADAKPKAADYMKAVVVIQRHYRIYLKKKQEQNRLKHGPVSLATAAIIIQRAY-- 304
            |.|:.|..........:....:..::.:.::.:|..:..|..|         ||.|.::...|
Human   894 ACLQFSYTGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWN---------ATFAKVMMLVYPE 949

  Fly   305 --RRMVARHKAKRTTSI-GTDQAEELNDNASETGSYTSVSTALLSTESTELG--MANFEERVHQK 364
              :.::.:.|.|....: |.:..|.:.::   :|.|:.      .||:::|.  ::..|.:.:.|
Human   950 ELKPVLTQAKQKFLLLLPGLETVEMMEES---SGPYSD------GTENSQLNVKISGMERKSNGK 1005

  Fly   365 ----IIHEDEEVENSNVDAGLRKEYFAETIKG-----EQKSINL---------RKSEILSGALIE 411
                :.....:.||....|.|:.|..:..:||     |:||.:.         .|..||:....|
Human  1006 RDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKE 1070

  Fly   412 SMICK----PDLQNIKDLNNE------SKEIDVELEVNEHQPAKLEEHITDEKKTI--QDSESEL 464
            .:..|    |.:.|..|::.:      |:|..:|:.....:|.:      |.|..|  :..:|::
Human  1071 VLKTKRCDIPAMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKE------DSKMMITEEQMDSDI 1129

  Fly   465 IVDNKTSLDLETLSQVEVKAENKSKDYKSASEDQLKSNK--SLDAEQETHVDSKDKPLANDLDDA 527
            ::....:.|......:|              :..|.:|:  |||         |..|
Human  1130 VIPQDVTEDCGMAEHLE--------------KSSLSNNECGSLD---------KTSP-------- 1163

  Fly   528 IKAEDSSSDLLRENREEDSALHRNTEKKESEDVQENIVESAIASSNNARN----------VEKED 582
               |.|:|:    |.|...||  .:.:|.|.:...:...|.:.||::..|          ..:..
Human  1164 ---EMSNSN----NDERKKAL--ISSRKTSTECASSTENSFVVSSSSVSNTTVAGTPPYPTSRRQ 1219

  Fly   583 EIIPLPKIQNSKSQLQEISLKNKITPTVSIEIEHVEDILE-----------------DSSASPND 630
            ..|.|.|...|:::....|..|.|:.||::: .:.|.:::                 ||....|.
Human  1220 TFITLEKFDGSENRPFSPSPLNNISSTVTVK-NNQETMIKTDFLPKAKQREGTFSKSDSEKIVNG 1283

  Fly   631 SKADDLTEGIS-----------VTEEPKSIPNVEVDSLKSILINHNLEGCEQETSAETIVDINFE 684
            :|......|.:           :..||:......|:.:  :::.:|..|...:|  |.:.|....
Human  1284 TKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEGI--VVLENNPPGLLNQT--ECVSDNQVH 1344

  Fly   685 AAAAKQDIDSNEMIQSSDTHEKIREKRSIEYEDNVQLNSDSQN-----VLIAESPIDQE-QLKIN 743
            .:.:..:.|:.::..::..:..:.|..::| |.||::|.:|:.     |:.|:..:::: |::|.
Human  1345 LSESTMEHDNTKLKAATVENAVLLETNTVE-EKNVEINLESKENTPPVVISADQMVNEDSQVQIT 1408

  Fly   744 -NDQTLELD--RKPEIIPKVEDVPKTTPNTKDDEVSGSTEKLEMNKEE--PLDET-VELSNHEIT 802
             |.:||...  |:.|::       ::|..::|.|  .|.:|.|..|||  ||.:: :.:.:..:.
Human  1409 PNQKTLRRSSRRRSEVV-------ESTTESQDKE--NSHQKKERRKEEEKPLQKSPLHIKDDVLP 1464

  Fly   803 LSKVL--KTVSENKQERMEDLPSEDKIVKDSTSSLAEDSKMPEAKKESKSID--ELETTKEVLED 863
            ..|::  :|:.||..|:..:|..:         :|.|.|...|.::..|..|  .:::..:..:|
Human  1465 KQKLIAEQTLQENLIEKGSNLHEK---------TLGETSANAETEQNKKKADPENIKSEGDGTQD 1520

  Fly   864 IIHS------------ETDLSKQNIKENVEETDKPQSD---------------DSPKELENLKDK 901
            |:..            :|..:.|.:..::|.::...|:               :...|..:::|:
Human  1521 IVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQ 1585

  Fly   902 IKMLTQEEVTPIEPESLETKGLLSTD---------KNDKNSLFSKTNSEENNNESQNVDDITEKT 957
            .:.:.::|....|.:|.:.|.....|         |.|:::.....:|...::..|..||:....
Human  1586 EEKVVKQECIKAENQSHDYKATSEEDVSIKSPICEKQDESNTVICQDSTVTSDLLQVPDDLPNVC 1650

  Fly   958 DLKNEKHLLASHISVTSSGIDDNDIQNTAASAELSVIDG--DISIRES----------------- 1003
            :.|||....|.: |.||..:.:::::...|...|...|.  :.|:.||
Human  1651 EEKNETSKYAEY-SFTSLPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQ 1714

  Fly  1004 --ETKHVENREEMASTNLD----SDQVENMKLEG---------EIGQLKTVFEQSEEKTSPTKSE 1053
              |.:|..:|....|...|    ..|.:...|.|         ||.:.|....|:....|.|...
Human  1715 TLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQA 1779

  Fly  1054 SLHAEDRKISGKSKESLE-DAGDENRAVEE--IIDITENDRSTLLENLPS---SEKENSTSLDEN 1112
            :.::|.:.:......:.. ...::|..:.:  |:..|::..:|:.|:|||   :.:|....:|.:
Human  1780 NPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSS 1844

  Fly  1113 PLPEKESTSLDEKPSSGTEKST---SLDEKSSSEKEKSTSLDEKPSSEKEKSTSLDETPSSEKEN 1174
                 |:.||:.:.|......|   .|.:..:..:|...:.:|||....:...||:..  :.:.|
Human  1845 -----EAMSLESQESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENV--TVEGN 1902

  Fly  1175 STSLDEKPSPEKESTSL---DEKPSSGTEKS-TSLDEKSSSEKEK---STSLDEKPSSEKEKSTS 1232
            :..:.|....:.::..|   :|....|.|:: |.:.|:::.|:.|   .:..|....:.||.:|
Human  1903 ACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVAT- 1966

  Fly  1233 LNERPSSEKENSTSLVENPSPEK--ESTSLDEKPSSG-TEKSTSLDENPSSEKEKSTSLNERP-- 1292
                  .|..:..||.:|.:|.|  ..|.:.|:.::| .:....:.:..|||:..:...|...
Human  1967 ------EEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMM 2025

  Fly  1293 ------------SSEKENSTSQDEKP-SSETEKSTS-LDEKPSSEKEKSTSLDGKPSSEKEKSTS 1343
                        .:|.|..|::..|| .:||...|: :|.......|.||. :|...:.|.: |:
Human  2026 IGEAMAETGHDGETENEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTE-EGIIDANKTE-TN 2088

  Fly  1344 LDENPSSEK-EKSTSLNERPSSEKENSTS-LVENPSPEKESTSLDEKPSSGTEKSTSLDENPSSE 1406
            .:.:.|.|| :.:..:.|....::::.|| .||.||         :..:|||..|..:.|:.::.
Human  2089 TEYSKSEEKLDNNQMVMESDILQEDHHTSQKVEEPS---------QCLASGTAISELIIEDNNAS 2144

  Fly  1407 KEKSTSLNERPSSEKENSTSQDEKPSSEKEK---STLLDKNTDLMRDLIQVSQKVDEEMSKGKAA 1468
            .:|...|:  ||     ..|.::.||..:.:   |.|...:|.:::..::.||  ::|:|.....
Human  2145 PQKLRELD--PS-----LVSANDSPSGMQTRCVWSPLASPSTSILKRGLKRSQ--EDEISSPVNK 2200

  Fly  1469 IAVVDLPDINKGESVNSPLEKKPS-----SQELEDIQAELSTDKETGEPYNLSAEKHSESETSNK 1528
            :..|...|......:...::::.|     |.....|...:.|...|...:|.::.|...|..|..
Human  2201 VRRVSFADPIYQAGLADDIDRRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRS 2265

  Fly  1529 PNNTTSKE-IEGEDSRDH--TKVEPISKKTIETTDVVDVGLKGNDDPSKPGKTETAATKSVSPDI 1590
            |...:||: :..|.:::.  ...|.:....:.....||:.|        |..|.....:.:...|
Human  2266 PKFKSSKKCLISEMAKESIPCPTESVYPPLVNCVAPVDIIL--------PQITSNMWARGLGQLI 2322

  Fly  1591 KDKDTLKLKPDDDSPQKSEVITAELQLKSFKTPNDDGAWYDIYVEPKITAERDLFVPPAPIETKR 1655
            :.|: :|...|..:...||:.|  |.::|.|..|...| ..||.|.::.......:|...|..|.
Human  2323 RAKN-IKTIGDLSTLTASEIKT--LPIRSPKVSNVKKA-LRIYHEQQVKTRGLEEIPVFDISEKT 2383

  Fly  1656 PNSAKEVASVVEEPMIISERTPSYYTPKEIVESVK---PKPKNSV----SFFVSFDSDD-----G 1708
            .|..:..:...:|..::|          :|::.|.   |..||.:    :..:..||:|     |
Human  2384 VNGIENKSLSPDEERLVS----------DIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSG 2438

  Fly  1709 KPKYKIPKRFQSQSN---KNAQ 1727
            ...:::.::....:|   ||.|
Human  2439 SQLFEMHEKLSCMANSVIKNLQ 2460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	74/345 (21%)
RIF1	NP_060621.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Rif1_N	20..361	CDD:289035
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1192		17/86 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1265..1318		7/52 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1464		18/74 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1587		16/116 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1762..1782		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1846..1889		9/42 (21%)
		Interaction with condensed chromosomes in telophase	1924..2472		123/586 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1992..2021		5/28 (18%)
		Interaction with ERCC6. /evidence=ECO:0000269\|PubMed:29203878	2170..2446		58/299 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2227..2269		9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000