DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and RSF1

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	NP_057662.3	Gene:	RSF1 / 51773	HGNCID:	18118	Length:	1441	Species:	Homo sapiens

Alignment Length:	1550	Identity:	330/1550 - (21%)
Similarity:	540/1550 - (34%)	Gaps:	522/1550 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 EKKTIQDSES-ELIVDNKTSLDLETL----SQVE-VKAENKSKDYKSASEDQLKSNKSLDAEQET 511
            |::..||..| :.||.|:..| .|||    :|:: |..:|.|:...|:.|.....::....|:||
Human   178 EEQDDQDGSSWKCIVRNRNEL-AETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEET 241

  Fly   512 HVDSKDKPLANDLDDAIKAEDSSSDLLRENREEDSALHRNTEKKESEDVQENIVESAIASSNNAR 576
            ....:.|.     .:.:|:|:...||  |||...:.|...|.|||.||
Human   242 PKQEEQKE-----SEKMKSEEQPMDL--ENRSTANVLEETTVKKEKED----------------- 282

  Fly   577 NVEKEDEIIPLPKIQNSKSQLQEISLKNKITPTVSIEIEHVEDILEDSSASPNDSKADDLTEGIS 641
                |.|::.||.|...:..|.|
Human   283 ----EKELVKLPVIVKLEKPLPE------------------------------------------ 301

  Fly   642 VTEEPKSIPNVEVDSLKSILINHNLEGCEQETSAETIVDINFEAAAAKQDIDSNEMIQSSDTHEK 706
              .|.|.|...|.||.|                 |.:..|..|....:.|        ..||...
Human   302 --NEEKKIIKEESDSFK-----------------ENVKPIKVEVKECRAD--------PKDTKSS 339

  Fly   707 IREKRSIEYEDNVQLNSDSQNVLIAESPIDQEQLKINNDQTLELDRKPEIIPKVEDVPKTTPNTK 771
            :                        |.|:.||               ||.|
Human   340 M------------------------EKPVAQE---------------PERI-------------- 351

  Fly   772 DDEVSGSTEKLEMNKEEPLDETVELSNHEITLSKVLKTVSENKQERMEDLPSEDKIVKDSTSSLA 836
              |..|:.:                |:||||         |...|..|.|.::
Human   352 --EFGGNIK----------------SSHEIT---------EKSTEETEKLKND------------ 377

  Fly   837 EDSKMPEAKKESKSIDELET------------TKEVLEDIIHSETDLSKQNIKENVEETDKPQSD 889
            :.:|:|..|:|.|..|:.::            |||.|:|.|..|            |||.|..|
Human   378 QQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQE------------EETCKRIS- 429

  Fly   890 DSPKELENLKDKIKMLTQEEVT-----------PIEPESLETKGLLSTDKNDKNSLFSKTNSEEN 943
                .:..|..:.|.|...||:           |||.:..|||....:...|:|.:     :|.|
Human   430 ----TITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNII-----TEGN 485

  Fly   944 NNESQNVDDITEKTDLKNEKHLLASHISVTSSGIDDNDIQNTAASAELSVIDGDISIRESETKHV 1008
            ..||.|                     ||.:| :...:::...|...... |..||:.|..::..
Human   486 GTESLN---------------------SVITS-MKTGELEKETAPLRKDA-DSSISVLEIHSQKA 527

  Fly  1009 ENRE----EMASTNLDSDQVENMKLEGEIGQLKTVFEQSEEKTSPTKSESLHAEDRKISGKSKES 1069
            :..|    || .|:|||.::.               :....||:.:.:||...:..:.|.|:|
Human   528 QIEEPDPPEM-ETSLDSSEMA---------------KDLSSKTALSSTESCTMKGEEKSPKTK-- 574

  Fly  1070 LEDAGDENRAVEEIIDITENDRSTLLENLPSSEKENSTSLDE-----NPLPEK--ESTSLDEKPS 1127
                              ::.|..:||.|...||...|.||:     :|:||:  :||...|||.
Human   575 ------------------KDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPG 621

  Fly  1128 SGTEKSTS-----LD--EKSSSEKE----KSTSLDEKPSSEKEKSTSLDETPSSEKENSTSLDEK 1181
            |.....||     :|  ||.:||||    :|||.....|.:|....:|.|.....|....:||
Human   622 SPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLD-- 684

  Fly  1182 PSPEKESTSLDEKPS--SGTEKSTSLDEKSSSEKEKSTSLDEKPSSEKEK-STSLNERPSSEKE- 1242
                ...||..|:||  .|:.:.:....|...|:|.:.|.:.:.:||::| ...|..|.||.|:
Human   685 ----NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKK 745

  Fly  1243 -NSTSLVENPSPEKESTSLDEKPSSGTEKSTSLDENP--SSEKEKSTSLNERPSSEKENSTSQDE 1304
             :|...|..|..::|.|   ||....|....:|..:|  |....|...:.:: .::|:....:||
Human   746 PDSPPKVLEPENKQEKT---EKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQ-KADKKRGEGEDE 806

  Fly  1305 KPSSETEKSTSL---DEK---PSSEKEKSTSLD-----------GKPSSEKEKSTSLDENPSSEK 1352
                ..|:||:|   |:|   ..|||:.::.:.           |..:..:.|.:|.||:..|..
Human   807 ----VEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGS 867

  Fly  1353 EKSTSLNERPSSEKENSTSLVENPSPEK--------ESTSLDEKPSSG----------------- 1392
            |||::.:|....::.....|.::..|.|        |...|.:...||
Human   868 EKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGE 932

  Fly  1393 ---------------TEKSTSLDENPSSEKEKSTSLNER------------PSSEKENSTSQDE- 1429
                           .|:...||. ...:||::....||            |..|.:.|..|:|
Human   933 WFCPPCQHKLLCEKLEEQLQDLDV-ALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEK 996

  Fly  1430 KPSSEKEKSTLLDKNTDLMRDLI-----QVSQKVDEEMSKGKAAIAVVDLPDINKGESVNSPLEK 1489
            |..|:|.|:.||::.:...|..|     :..:.:||.:...   |...|...:.:|:.:::
Human   997 KKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDD---IKEADGGGVGRGKDIST---- 1054

  Fly  1490 KPSSQELEDIQAELSTD-KETGEPYNLSAEKHSESETSNKPNNTTSKEIEGEDSRDHTKVEPISK 1553
             .:....:||...|..: ||...|...:|.:..:....|..::.::  ::.|:|.|..|:...|:
Human  1055 -ITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSN--LDEEESEDEFKISDGSQ 1116

  Fly  1554 KTI----ETTDVVDVGLKGNDD-------------PSKPGKTETAATKSVSPDIKDKDTLKLKPD 1601
            ...    |..|..:.....|||             ||:|.:.        |..::.|...|...|
Human  1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQ--------SRRLRRKTPKKKYSD 1173

  Fly  1602 DDSPQKSEVITAELQLKSFKTPNDDGAWYDIYVEPK-----------ITAERDLFVPPAPIETKR 1655
            ||..::||    |....|....:||  :.|.:||.:           |..:.|   ..:....|.
Human  1174 DDEEEESE----ENSRDSESDFSDD--FSDDFVETRRRRSRRNQKRQINYKED---SESDGSQKS 1229

  Fly  1656 PNSAKEVASVVEEPMIISERTPSYYT--------PKEIVESVKPKPKNSVSFFVS---FDSDDGK 1709
            ....||:..|.:..:..||...||.:        .||...||:.:.:::..:..:   .:.::||
Human  1230 LRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGK 1294

  Fly  1710 PKYKIPKRFQ--------------SQSNKNAQKEV--KAIEATQSESDIDSNEEEIEIIEVSEGD 1758
            |..|...|.:              :|..:::|..|  ...|:|:....|:|:|||
Human  1295 PSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEE---------- 1349

  Fly  1759 PEYQQTG--GTKLQ-TILELDNENEMTYEFNSQGQGLELNLNESNVEKPKSPTNS 1810
             :::..|  |:.|. ::::|.:.|.     .|.|:.:| ||.....||.::|.::
Human  1350 -DFENVGKVGSPLDYSLVDLPSTNG-----QSPGKAIE-NLIGKPTEKSQTPKDN 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	97/403 (24%)
RSF1	NP_057662.3	WHIM1	98..148	CDD:292246
		WHIM2	150..182	CDD:292247	1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..283		22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..385		23/154 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..634		51/230 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..887		55/225 (24%)
		PHD_RSF1	893..938	CDD:277018	6/44 (14%)
		BAH	915..>968	CDD:295389	6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1007		9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1063..1428		77/370 (21%)
		CDC45	1093..>1171	CDD:280821	16/87 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000