Protein Alignment CG14692 and LOC4576986

DIOPT Version :10

• Sequence 1: NP_650019.6
• Gene: CG14692 / 41298
• FlyBaseID: FBgn0037836
• Length: 2851
• Species: Drosophila melanogaster
• Sequence 2: XP_061502451.1
• Gene: LOC4576986 / 4576986
• VectorBaseID: AGAMI1_001606
• Length: 1646
• Species: Anopheles gambiae
• Alignment Length: 1979
• Identity: 422/1979 - (21%)
• Similarity: 692/1979 - (34%)
• Gaps: 712/1979 - (35%)

  Fly  1186 KESTSLDEKPSSGTEKSTSLDEKSSSEKEKSTSLDEKPSSEKEKSTSLNERPSSEKENSTSLVEN 1250
            ||.|    :...|..|..||.:.:..:.::|.|...:......|.....:..:.|::|.|::|.|
Mosquito    67 KEKT----REKLGLTKDPSLSDGNGGDGDESGSGGSESKMRGRKRRRARKPTTRERDNPTTMVGN 127

  Fly  1251 PS------PEK-ESTSLDEKPSSGTEKS-TSLDENPSSEKEKSTSLNERPSSEKENSTSQ--DEK 1305
            ||      |:| :|.|.:..|:...|:. ..:..||.........:....|.|.|::.|.  |::
Mosquito   128 PSVSDEGEPQKLKSLSEESAPAPVVEQEIVKVHYNPPEATPSPGRVVSAQSVEAEHAVSSILDDE 192

  Fly  1306 PSSETEKSTSLDEKPSSEKEKSTSLDGKPS----SEKEKSTSLDENPSSEKEKSTSLNERPSSE- 1365
            ...:::.:|...|......:....:...||    :|:.:..::|             |..||.|
Mosquito   193 QILDSDGTTGGKETGDELVDNGDDIGTAPSTAEVAERPRVPTVD-------------NLEPSGEM 244

  Fly  1366 --KENSTSLVE-NPSPEKESTSLDEKPSSGTEKSTSLDENPSSEKEKSTSLNE------------ 1415
              ::..|..|: |.....|..|.|.|    ||:...|...|...|..|.:..|
Mosquito   245 PLQDMETCFVQANVDDLLEKHSEDYK----TEQGNELGGVPEETKVSSVTTGEGEDIPEGPQVEV 305

  Fly  1416 RPSSEKENSTSQD--EKPSSEKEKSTLLDKNTDLMRDLIQVSQKVDEEMSKGKAAIAVVDLPDIN 1478
            :|.|..:..||||  |.|..:       |:||::.. :.|..|:||.|     |..|.|:
Mosquito   306 QPKSVGDEGTSQDAHEVPKDD-------DENTEIQM-VGQEEQQVDSE-----ARPAAVE----- 352

  Fly  1479 KGESVNSPLEKKPSSQELEDIQAELSTDKETGEPYNLSAEKHSESETSNKPNNTTSKEIEGEDSR 1543
             |..::|  |.||...|..::||....|   |...|...|...::|:..:.....:.||:.|::.
Mosquito   353 -GAELDS--ETKPIPVEGTEVQAAADFD---GSEENNDKEDKIDNESGKQDETLVTNEIKPEEND 411

  Fly  1544 DHTK---VEPIS-------KKTIETTDVVDV-------GLKGNDDPSKPGKTETAATK-SVSPDI 1590
            :..|   ..|::       .|..:..|.|||       .|...|:.:|..:.:|::.. |..|:.
Mosquito   412 EIVKESASSPVAMDKDDDQTKANDGEDTVDVLVDETADNLTKKDEQAKLSENQTSSEAISTLPNN 476

  Fly  1591 KDKDTLKLKPDDDSPQKSEVITAELQLKSFKTPNDDGAWYDIYVEPKITAERDLFVPPAPIETKR 1655
            :.|......|  ||.:|||      :..|.:| .:||    :.:.|::..|.|     .|:||..
Mosquito   477 EQKPNTPTTP--DSIEKSE------EHSSAQT-TEDG----LKIAPRMGFEDD-----EPLETAD 523

  Fly  1656 PNSAKEVASVVEEPMIISERTPSYYTPKEIVESVKPKPKNSVSFFVSFDSDDGKPKYKIPKRFQS 1720
                                     ||.:.::.|....:|::.   :.||.|     ||     |
Mosquito   524 -------------------------TPSKTLDLVGIDVENAIE---NVDSPD-----KI-----S 550

  Fly  1721 QSNKNAQKEVKAIEATQSESDIDS----NEEEIEIIEVSEGDPEYQQTGGTKLQTIL-ELDNENE 1780
            .:|    .|:|.||.|.:|..:::    ::|||| ..|.:.:|..|.      |:|: |:..::|
Mosquito   551 TTN----TELKTIETTANEDVLEAESSKDDEEIE-TAVKDAEPAEQD------QSIVSEIPVKDE 604

  Fly  1781 MTYEFNSQGQGLELNLNESNVEKPKSPTNSINEFETAYKTDILNITRSVEIIERAYKRFKNRSSL 1845
                   |...|.|||:|..:||                                       :.|
Mosquito   605 -------QDTPLNLNLSELTMEK---------------------------------------NDL 623

  Fly  1846 KSEPGNESDFENQNRAAIVIQKWVRNTLKQKAYDTQKSKQSLAARKIQRAYRRYVEKAKQRTQKQ 1910
            :.:|.:::.|:                                            :.|||.:.:|
Mosquito   624 EVQPESKTSFD--------------------------------------------DDAKQGSDEQ 644

  Fly  1911 EMAALIIQKAFIRYSHRIRTEPNKTQSLVNIELKQNNAAFKIQRAYRRYLKLQSERHQDAGIPVK 1975
            :.|.:         ..:..|| ||.:        ::|||..:.....:..|.::|.|   .:..|
Mosquito   645 QEAEV---------DAKGETE-NKPE--------ESNAAQSVNNDANQETKQENETH---AVEAK 688

  Fly  1976 DDSVSLINSVKLPTEPEIVNKLNSNDEHKVNLIPIHNQKVADYPEIIKEVQPEEPNDVLREAETE 2040
            ||::|  |:..:.|: .|..|.|...:...:  |:.:|:|.|             :....|:..:
Mosquito   689 DDALS--NAEMIVTD-SIEEKGNQLSDPATD--PVIDQEVTD-------------DQQATESSID 735

  Fly  2041 SNTILLSDLTEKHKETNEMHKKGSQELASVSAEVEKP---MDASKLPTENRRDEKQVVE------ 2096
            .:.|...::.||::..|....:         .||.|.   .||:.|.|::|..|..|.:
Mosquito   736 KSDIAKPEIEEKNESANTQENE---------HEVNKEHNVTDANDLLTKDRSLEDVVCDDATASG 791

  Fly  2097 TISPPINLTQLSAEPKRVKELK--SDGFQEIENLSNANFNPKSSTKSPDEIDLQPLEQAQKLVEI 2159
            |:.|....::...|.|..::.:  .||      ::||                 |.:..:.:|
Mosquito   792 TVIPEATSSEGIVEDKVAEQAEPLDDG------MNNA-----------------PAKVTEGVV-- 831

  Fly  2160 EKPSEEMK-TELTNLSQASPNHPLKDDLVEKSNAALIIQRAFRQYMERRKFENFEDSSIDSITSS 2223
               |||.| ..:|:..:...|   ||:..|:.:                     |...:|.
Mosquito   832 ---SEEPKDCPVTDTEECGVN---KDEKQEQES---------------------EQMKVDD---- 865

  Fly  2224 RITAIETANYPTAGTPSRSLIQEAIGDPGDTLEDTSNIQPKSEWFVGSTRIIPSQGVVEGPVEVE 2288
                                            ||.||                     |.|.|||
Mosquito   866 --------------------------------EDKSN---------------------EKPAEVE 877

  Fly  2289 TNPDPATIATTSKAELTTSTQVESVETVDRSHGSLESKLNPGTIIDDCLGDASEKDNAISSGLAG 2353
            .   |..:.|........|..||.::.:..:...|:.  ...||:.|.:..:|.|:...:...|.
Mosquito   878 A---PTAVPTKDVTPTLESVVVEEMQKLLSNENDLQQ--TESTIVQDKVSGSSSKEVEENVRDAS 937

  Fly  2354 LAKASEALFDSVEDPLLLSQSDFGGLVQSLD----IASTQELLNDFLQNEIEYSSRLGPFPSAK- 2413
            .|..::|:..:.:.|:....||..|.|.|.:    :.:.:|...|. ::..:..:.|...|.|.
Mosquito   938 EADLNDAVILAADVPVETQSSDNVGEVGSGNDSDAVTAIKESSGDH-ESVADSKNALDQTPLASQ 1001

  Fly  2414 -----------LLEEVIEEPCIKRSAS------------------------LVNVSECESESDNA 2443
                       .||||:||||:||..:                        .|::|:...:|..|
Mosquito  1002 QTNEETPKREVSLEEVVEEPCVKREITPSKTGPLEKEDSTEKQVEEREEIKKVDLSQLSKDSAEA 1066

  Fly  2444 ------SQKVENTDSSISETAGLDTLSADTIDKATVKLSKPEE------VIEKMSQLRDSKSYER 2496
                  ..::||.|.:...|.|.|  ...|...|.::..|.||      |:::......|:...:
Mosquito  1067 LFYSLKKSELENQDPADGGTMGDD--HTTTATNAEIEPQKTEEDDDQDVVVKEEPVATSSEDRTK 1129

  Fly  2497 ISSTDPSFDE-PV------------------IRPISSLQEQSSLDIEDGDIIVYNRLQRDE---- 2538
            .:.||...|| |:                  :.|:...||::||:.::         |:||
Mosquito  1130 RTFTDDFLDETPITEAATPTTTLPCDGATKALDPLPMEQERTSLETDE---------QKDEFNPM 1185

  Fly  2539 ------TRESSAQSDSVVFGDAVSENNQE-----KELLNE---EESGRVHLMRHYTIAGDDPRGL 2589
                  :::...|..|...|:.:.|...:     :.::..   |.||   |.|:.....:||..
Mosquito  1186 VMVSMRSKQFQEQLHSRDAGEQLGEGQADDATPKRPIMRRCMTEMSG---LQRYDPAVDEDPAD- 1246

  Fly  2590 FRSVTIDDALSYMENGANGMGASSFCLDDETSENIRKKMMAYSLSETDSDYFDPKKVSSEDFD-- 2652
            .|..|.|.  ||:|....        .|.....:|:.|::|.|:|..|||..|..:.|.|..|
Mosquito  1247 SRPSTEDP--SYVEEEDQ--------FDGYYVGHIKNKILASSVSVADSDCPDGTRSSVESVDEN 1301

  Fly  2653 -VDTAMADAMGTSTETESTIVSAATKIQAGARGFLTRRRLRRASAGTKSSTLDTKASFGNDAISE 2716
             |.||:...  .||:|||||.|.||..|||.|.:     ||:.|..|.|:.  ..|||||.||.:
Mosquito  1302 QVRTALETI--ASTDTESTIASQATIQQAGRRSY-----LRKHSQNTSSNI--PYASFGNAAIDQ 1357

  Fly  2717 SLERFIEE-----------EAAKKIQTAYRMHTRK--RKGHS----------------------- 2745
            ||:.|||.           |||.|||.:||.|.:|  |..||
Mosquito  1358 SLDEFIEREEQHKQDEAMAEAATKIQRSYRTHKKKLLRDYHSTMRTCTEDQSAESGEEYAASVIQ 1422

  Fly  2746 --------------------------------------RKMEGISL-ESNLAARRQKLQRGDALR 2771
                                                  |.|..::: |.:..|||..|.||.|::
Mosquito  1423 IKLDQRRPDGPDPAEGDAGEESDSATASHQQPLGATGRRPMYSLNIDEYDTVARRMTLTRGVAMQ 1487

  Fly  2772 NDSTPDDEN------------SLLVSGVKAHKNAKTQRSKTVGEAKSSAD--------------- 2809
            .:|||:|::            ||..|...|.|::.........|::||:|
Mosquito  1488 RNSTPEDDSGKSSNVSTDRKPSLTSSVATAKKDSAPASESGASESRSSSDEKPPKADATQGSSDE 1552

  Fly  2810 ----------------------------------------------MELRWLKM--RQNSMPVQI 2826
                                                          ::::.|.:  ||.:|||||
Mosquito  1553 PEPKDGALNSSRSKPKSGPAGTVTGREQHPVSAPRTATSLRTSFAPLDVQSLLLIARQRTMPVQI 1617

  Fly  2827 DCEVFRVIPKHMRKRIKSA---EAN-KRK 2851
            |..|.||:||||||||.||   :.| |||
Mosquito  1618 DSSVIRVLPKHMRKRISSAGMLDGNGKRK 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_RII_PKA-like	9..44	CDD:438517
		DD_RII_PKA-like	82..116	CDD:438517
		PTZ00121	<684..1400	CDD:173412	49/231 (21%)
		PTZ00108	<1155..1402	CDD:240271	50/233 (21%)
		PTZ00112	1288..>1580	CDD:240274	74/332 (22%)
		IQ	2674..2692	CDD:197470	6/17 (35%)
LOC4576986	XP_061502451.1	None