Protein Alignment CG14692 and ice1

DIOPT Version :9

• Sequence 1: NP_650019.6
• Gene: CG14692 / 41298
• FlyBaseID: FBgn0037836
• Length: 2851
• Species: Drosophila melanogaster
• Sequence 2: NP_001030137.2
• Gene: ice1 / 327355
• ZFINID: ZDB-GENE-030131-5566
• Length: 1491
• Species: Danio rerio
• Alignment Length: 1805
• Identity: 355/1805 - (19%)
• Similarity: 608/1805 - (33%)
• Gaps: 606/1805 - (33%)

  Fly   331 ASETGSYTSVSTALLSTESTELGMANFEERVHQKIIHEDEEVENSNVDAGLRKEYFAETIKGEQK 395
            |||..|.|..:..:|:....|...|..  .:.|||:..|.          :..||       ::|
Zfish    14 ASEATSGTCQNCTVLNQSLDEYVAALL--TLKQKIVDTDH----------ILTEY-------KEK 59

  Fly   396 SINLRKSEILSGALIESMICKPDLQNIKDLNNESKEIDVELEVNEHQPAKLEEHITDEKKTIQDS 460
            ...|:||:                :....|:.:..|:.::||..|.|..|.|:..|:    ::::
Zfish    60 CDELQKSQ----------------RESSTLHRQLDEVLLKLEPLEKQTVKYEQMKTE----LENT 104

  Fly   461 ESELIVDNKTSLDLETL----SQVEVKAENKSKDYKSASEDQLKSNKSLDAEQETHVDSKDKPLA 521
            ::||.::.:...|::.|    :|:.:..|...:..:.| ||.||..   |.|.|...:.| :.|.
Zfish   105 KAELELNQQRCKDVDRLKEKNAQIIILKEKLEESLRKA-EDTLKGQ---DLENEKLKNGK-QLLE 164

  Fly   522 NDLDDAIKAEDSSSDLLRENREEDSALHRNTEKKES---EDVQENIVESAIASSNNARNVEKEDE 583
            .||.   |.:||    ||:       .|:.:|:.||   |:.:..|::.         |:|.|..
Zfish   165 EDLQ---KMQDS----LRK-------YHQTSEEHESLKLENAKTLILKG---------NLENELL 206

  Fly   584 IIPLPKIQNSKSQLQEISLKNKITPTVSIEIEHVEDILEDSSASPNDSKADDLTEGISVTEEPKS 648
            ::...|.|..|.....|:.|.::           |::|..:..:.|..:.:...|..|::.:..|
Zfish   207 VLKELKCQQDKEVGALINEKRRL-----------EEMLFTTQQNLNKLQKEFNKEKRSMSSQTDS 260

  Fly   649 IPNVEVDSLKSILINHNLEGCEQETSAETIVDINFEAAAAKQDIDSNEMIQSSDTHEKIREKRSI 713
            .|.::.|.::.:|                                 .|:....:|..|.:||..:
Zfish   261 EPTIDKDKVRMLL---------------------------------EELWHCVETSNKTQEKLLL 292

  Fly   714 EYEDNVQ---------LNSDSQNVLIAESPIDQEQLKINNDQTLELDRKPEIIPKVEDVPKTTPN 769
            ..|:..|         |||.|:..:...||               ....||....:..:|||.|
Zfish   293 TGEETTQLKRIPSQPRLNSPSERHIFHPSP---------------GKASPETQSSILSMPKTPP- 341

  Fly   770 TKDDEVSGSTEKLEMNKEEPLDETVELSNHEITLSKVLKTVSENKQERMEDLPSEDKIVKDSTSS 834
                       ::...||.|.           .|.|.......|.|.|...:.|:   |.:...:
Zfish   342 -----------RVSRPKESPQ-----------KLKKQNNVQQFNTQSRKRKVSSD---VLEQVDT 381

  Fly   835 LAEDSK--MPEAKKESKSIDELETTKEVLEDI------IHSETDLSKQNIKENVEETDKPQSDDS 891
            |.:|||  ..|.........:|...||..:.:      :||.: |...|:.:|...:|..|.::|
Zfish   382 LTDDSKEMTCEGLLHGDYCMDLLALKEWFKPLPPVLSPVHSPS-LELVNVNDNKPMSDTQQENES 445

  Fly   892 PK-------------ELENLKDKIKMLTQEEVT--PIEPESLETKGLLSTDKNDKNSLFSKTNSE 941
            ..             ||.::.||..:|.:||.|  .:.|::| |:..:|.|..|          .
Zfish   446 SNEKSKTLASLHEELELSDIGDKKSLLKEEEGTCSLLCPDTL-TRSTVSVDNLD----------S 499

  Fly   942 ENNNESQNV--DDITEKTDLKNEKHLLASHISVTSSGIDDNDIQNTAASAELSVIDGDISIRESE 1004
            |..:|||||  :|:.|.|            :...:..:.|:.......|.|:|:::||
Zfish   500 EKTSESQNVEAEDMCEVT------------LGCVADSLSDHAKLAPEKSVEISLVNGD------- 545

  Fly  1005 TKHVENREEMASTNLDSDQVENMKLEGEIGQLKTVFEQSEEKTSPTKSES---LHAEDRKISGKS 1066
                                     .|..|:|            |.|:|:   .|.||.|::.|.
Zfish   546 -------------------------TGTAGEL------------PLKNENGEKAHLEDAKVTDKF 573

  Fly  1067 KESLEDAGDENRAVEEIIDITENDRSTL------LENLPSSEKENSTSLDENPLPEKESTSLDEK 1125
            ...||::........:|:|.:.::.|..      :.::.|:.|.||.. |.|.|
Zfish   574 TNMLENSDPCQWNESKIVDTSSSEFSECKTQEQPIVSVASNVKRNSMG-DMNCL----------- 626

  Fly  1126 PSSGTEKSTSLDEKSSSEKEKSTSLDEKPSSEKEKSTSLDETPSSEKENSTSLDEKPSPEK--ES 1188
                                ||.:::.|   |.:.|.||:  .:|.:::||...:...|:|  :|
Zfish   627 --------------------KSKNIENK---ESKISVSLE--INSAQDSSTQDVQNRLPDKAVQS 666

  Fly  1189 TSLDEKPSSGTEK-STSLDEKSSSEKEKSTSLDEKPSSEKEKSTSLNERPSSEKENSTSLVENPS 1252
            ..:.|..||.|.| ..|||.:.:.:...|.:..::.||:.|....|....|.:     :..|..:
Zfish   667 EDISEDISSVTIKCKKSLDVRENGDLCSSKTSSDELSSKDEGIFGLMGEVSDQ-----AWSEGRA 726

  Fly  1253 PEKESTSLDEKPSSGTEKSTSLDENPSSEKEKSTSLN-ERP----SSEKENSTSQDEKPSSETEK 1312
            ..|:..:|.|.....|.|..|.||......|..|..| |||    :||:|.|.:|.|  |.||.|
Zfish   727 HPKKLENLSEFEQCSTAKQMSKDEPQEFLSESKTQSNAERPLVVINSEQERSANQQE--SGETCK 789

  Fly  1313 STSLDEKPSSEKEKSTSLDGKPSSEKEKSTSLDENPSSEKEKSTSLNERPSSEKENSTSLVENPS 1377
            ..                    |||..:.|....|..:::....|    |.|:.:|:::|..:..
Zfish   790 EN--------------------SSESPRKTMQVNNTFNQEADEMS----PVSQSQNASNLASDKH 830

  Fly  1378 PEK-ESTSLDEKPSSGTEKSTSLD-ENPSSEKEKSTSLNERPSSEKENSTSQDEKPSSEKEKSTL 1440
            .|. |.:.||....:.|....:|: ||.:.||:.:.|:                .|:|..:....
Zfish   831 KEALEDSVLDCLEDTSTPCQGTLNPENSTYEKDANVSV----------------VPNSNSKIHIT 879

  Fly  1441 LDKNTDLMRDLIQVSQKVDEEMSKGKAAIAVVDLPDINKGESVNSPLEKKPSSQELEDIQAELST 1505
            ..|...|        :||..||..        .||      .|..||...|
Zfish   880 PTKFLSL--------KKVRTEMGP--------PLP------PVVMPLTSTP-------------- 908

  Fly  1506 DKETGEPYNLSAEKHSESETSNKPNNTTSKEIEGEDSRDHTKVEPISKKTIETTDVVDVGLK--- 1567
                        .:.....|..||.:.:|...:|:.|.|.....|:...|:  :|..::|..
Zfish   909 ------------PRFGRHHTPLKPTSASSLSSDGQTSPDTIPPLPVVDSTL--SDASEIGPSTPS 959

  Fly  1568 ------------GNDDPSK----PGKTETAATKSVSPDIKDKDTLKLKPDDDSPQKS------EV 1610
                        |:..|..    ||:..::|..|..|....::::::. |...|:.|      .:
Zfish   960 SSCGVPSSPLQFGSATPKHAVPVPGRLPSSALSSSPPSASQENSMQML-DTMYPELSARARTLNI 1023

  Fly  1611 ITAELQLKSFKTPNDDGAWYDIYVEPKITAERDLFVPPAPIETKRPNSAKEVASVVEEPMIISER 1675
            :...:.|.  :..|::|.                          .|:|..:::.   ..||.|..
Zfish  1024 LRGNVNLN--QAANENGT--------------------------SPSSVNQISG---NKMISSAS 1057

  Fly  1676 TPSYYTPKEIVESVKPKPKNSVSFFVSFDSDDGKPK-----YKIPKRFQSQSNKNAQKEVKAIEA 1735
            |                         :|...:.|||     ..:||         :.|.:|....
Zfish  1058 T-------------------------AFTKTEQKPKRTGVNMLLPK---------SAKRLKLDNY 1088

  Fly  1736 TQSESDIDSNEEEIEIIEVSEGDPEYQQTGGTKLQTILELDNENEMTYEFNSQGQGLELNLNESN 1800
            ..:.:..||              |..|.||.   ||::|..:        ....|||..|..|..
Zfish  1089 LPAHAGADS--------------PAEQVTGN---QTVIETKS--------TQLHQGLPSNQKEQM 1128

  Fly  1801 VEK-PKSPTNSINEFETAYKT------DILNITRS---------VEIIERAYKRFKNRSSLKSEP 1849
            .|| |..|.:...:...|...      |:..:.:|         |.|:            :.:|.
Zfish  1129 TEKGPDKPNDENRQISDALDKLGMACFDVFPVVKSHIHLGRISQVPIL------------IDAEK 1181

  Fly  1850 GNESDFENQNRAAIVIQKWVRNTLKQKAYDTQKSKQSLAARKIQRAYRRYVEKAKQRTQKQEMAA 1914
            ...:||.....:|..:...:...||     |::|  .|:.:.||...|.|....:|....|:..|
Zfish  1182 AVIADFCVNQSSAEKLMFAILTKLK-----TERS--ILSCQHIQALCRVYTGICRQIGDYQKAHA 1239

  Fly  1915 LIIQKAFIRYSHRIRTE--PNKTQSLVNIELKQNNAAFKIQRAYRRYL--------KLQSER--- 1966
                     :::.|..|  |:.::.::.:.....|..|     |:.:|        ||:||.
Zfish  1240 ---------FAYNILKEDYPDASKLILFMITTWPNVFF-----YKTFLCKAIHTVAKLKSEEGIL 1290

  Fly  1967 -------HQDAGIPVKDDSVSLINSVKLPTEPEIVNKLNSNDEHKVNLIP 2009
                   |.:...|  |:...|||......:.:.......:|.|..:|.|
Zfish  1291 DCLTKYLHWEKSPP--DNINELINCTLKALQEDKDLSFQKHDRHGYDLCP 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	74/324 (23%)
ice1	NP_001030137.2	SMC_N	<28..815	CDD:308206	223/1074 (21%)
		Smc	52..>301	CDD:224117	68/347 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000