DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and Cobll1

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	XP_006499773.1	Gene:	Cobll1 / 319876	MGIID:	2442894	Length:	1274	Species:	Mus musculus

Alignment Length:	1456	Identity:	280/1456 - (19%)
Similarity:	484/1456 - (33%)	Gaps:	465/1456 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 AENKSKDYKSASEDQLKSNKSLDAEQETHVDSKDKPLANDLDDAIKAEDSSSDLLRENREEDS-- 546
            ||.|..|..|| ||.::|...:..:|:..:| ||..|:..|         ..|:|:......|
Mouse    58 AETKGTDVSSA-EDPVESTAVVTEQQDNMID-KDIELSVVL---------PGDILKSTTVHGSKP 111

  Fly   547 ----------ALHRNTEKKESE--DVQENIVESAIASSNNARNVEKEDEIIPLPKIQNSKSQLQE 599
                      ..|.|......:  ..:||:::....:.....:|||   :|..||
Mouse   112 MMDLLVFLCAQYHLNPSSHTIDLLSAEENLIKFKPNTPIGMLDVEK---VILKPK---------- 163

  Fly   600 ISL-KNKITP-----TVSIEIEHVEDILEDSSASPNDSKADDLTEGISVTEEPKSIPNVEVDSLK 658
             || |.|.||     ||.:.|...:........||: :...||.        |......|.|.|.
Mouse   164 -SLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPH-APLQDLA--------PIICSKCEFDPLH 218

  Fly   659 SILINHNLEGCEQETSAETIVDINFEAAAAKQDIDSNEMIQSSDTHEKIREKRSIEYEDNVQLNS 723
            ::|:.                  :::   |::.:|..:.:....    :||..:::
Mouse   219 TVLLK------------------DYQ---AQEPLDLTKSLNDLG----LRELYAMD--------- 249

  Fly   724 DSQNVLIAESPIDQEQLKINNDQTLELDRKPEIIPKVEDVPKTTPNTKDDEVSG-------STEK 781
                  |:.:|......|.:..::.::...|:|:             |:.|..|       |.:|
Mouse   250 ------ISRAPSATAFSKSSFQESCQISHNPDIV-------------KEKENKGIFSFFQRSKKK 295

  Fly   782 LEMNKEEPLDETVELSNH------EITLSK--VLKTV-SENKQERMEDLPSEDKIVKDSTSSLAE 837
            .|.....|  .|..:|.|      ..|:||  :..|: |:..::|...||.    :..|..:...
Mouse   296 REQTASAP--ATPLVSKHRPSFTRSNTISKPYISNTLPSDAPKKRRAPLPP----MPTSQGAAQG 354

  Fly   838 DSKMPEAKKESKSIDELETTKEVLEDII-------HSETDLSKQNIKENVEETDKP-------QS 888
            ..:.....:.|.|:|  :|.|...|.|:       .|.|.:...::|....:...|       |:
Mouse   355 QERRASCVERSTSVD--DTDKSSSEAIMVRTGSLQLSSTSIGTSSLKRTKRKAPAPPSKTPLAQT 417

  Fly   889 DDSPKELEN---LKDKIKMLTQEEVTPIEPESLET------KGLLS------------------T 926
            |:....:.:   |:|.|...:..|::  .||.:.|      .|.||                  |
Mouse   418 DERNSAMAHGLPLEDGIAPDSMLELS--SPEGMSTPEGSLGPGFLSQEQCAVPKPPDEISEGPGT 480

  Fly   927 DKNDKNSLFSKTNSEENNNESQNVDDITEKTDLKNEKHLLASHISVTSSGIDDNDIQNTAASAEL 991
            .:....||.|..:|:      .::::|.||.:|.......|..|||.|..|       .:||.::
Mouse   481 PEAAVASLTSGVSSD------YSLEEIDEKEELSEASKDPAGSISVKSPDI-------ASASTDM 532

  Fly   992 SVI-----DGDISIRESETK------------------------HVENREEMASTNLDSDQVENM 1027
            .:.     |..:.|.:.||.                        |:.|.:.:      ||.:::|
Mouse   533 RITVEKDPDSALGISDGETSPSSKGKTQEGRSTEGQGPYHPVVGHIGNEDRV------SDSIKDM 591

  Fly  1028 KLEGEIGQLKTVFEQSEEKTSPTKSESLHAEDRKISGKSKESLEDAGDENRAVEEIIDITENDRS 1092
            |   .:|..:....|:|.....|.::  :.::|  .||.:.::|..|:   |:::..|: |.||
Mouse   592 K---TLGPNQESVVQNEIMVCATSTD--YVKNR--PGKMETTIEGEGE---ALKKASDM-ETDR- 644

  Fly  1093 TLLENLPSSEKENSTSLDENPLPEKESTSLDEKPSS-GTEKSTSLDEKSSSEKEKSTSLDEKPSS 1156
              |...|:...:|..|..||.|  ..|...|:|.:. |.||:
Mouse   645 --LSGSPACRMDNVKSSRENHL--TASPGPDQKLNQPGVEKT----------------------- 682

  Fly  1157 EKEKSTSLDETPS-----SEKENSTSLDEKPSPEKESTSLDEKPSSGTEKSTSLDEKSSSEKEKS 1216
             |.:..::..||:     ...|.|.|.|.:                 .:::....:.|.|.:..|
Mouse   683 -KMQDAAIQATPARGTFDGNHEVSNSSDPR-----------------ADETVQTSDGSISAQHSS 729

  Fly  1217 TSLDEKPSSEKEKSTSLNERPSSEKENSTSLVENPSPEKE-----STSLDEKPSSGTEKSTSLDE 1276
            .||.:          |:|.......:.:::.|::..||||     ..::...|..|:.|
Mouse   730 ASLQD----------SVNASREFRSQGTSTYVQDRLPEKEPACTYGNNVPLSPVDGSNK------ 778

  Fly  1277 NPSSEKEKSTSLNERPSSEKENSTSQDEKPSSETEKS-------TSLDEKP--SSEKEKSTSLDG 1332
            ||::...|:..|..:.|:.|       .|||:|..:.       |:....|  |.|..|....:.
Mouse   779 NPAASYLKNFPLYRQDSNPK-------PKPSNEITREYIPKIGMTTYKIVPPKSLEMAKDWESEA 836

  Fly  1333 KPSSEKEKSTSLDENPSSEKEKSTSL-NERPSSEKENSTSLVENPSPEKESTSLDEKPSSGTEK- 1395
            ....:.:|...:.:..:.|....||: .|.|::.|.:     :.|.|:     |..|||||||:
Mouse   837 MGRKDDQKMLPVGQRHTIENMTETSMQTEVPATSKSS-----QQPQPD-----LKPKPSSGTERH 891

  Fly  1396 -------STSLDENPSSEKEKSTSLNERP-------------SSEKENSTSQDEKPSSEKEKSTL 1440
                   .|..:.||......:|.....|             |..:..:::...||||
Mouse   892 LHRTLSSPTGTETNPPKAPRVTTDTGTIPFAPNLEDINNILESKFRSRASNPQAKPSS------- 949

  Fly  1441 LDKNTDLMRDLIQVSQKVDEEMSKGKAAIAVVDLPDINKGESVNSPLEKKPSSQELEDIQAELST 1505
                     ..:|:.::.........||.:|...|         .|..|:|:.:|::. ..:||.
Mouse   950 ---------FFLQMQKRASGHYVTSAAAKSVHTAP---------GPAPKEPTIKEVQR-DPQLSP 995

  Fly  1506 DKETGEPYNLSAEKHSESETSNKPNNTTSKEIEGEDSRDHTKVEPISKKTIETTDVVDVGLKGND 1570
            ::   .|.:||...||    :..||                    |||   ...|::....:.:.
Mouse   996 EQ---HPSSLSERTHS----APLPN--------------------ISK---ADDDIIQKPAETSP 1030

  Fly  1571 DPSKPGKTETAATKSVSPDIKDKDTLKLKPDDDSP----QKSEVITAELQLKSFKTPNDDGAWYD 1631
            .|..|......|..|..|......||   |.:.||    .|...:.||..|.
Mouse  1031 PPVAPKPMTLRAETSPPPVFPKPMTL---PAETSPPPVFPKPMTLPAETSLP------------- 1079

  Fly  1632 IYVEPKITAERDLFVPPAPIETKRPNSAKEVASVVEEPMIISERTPSYYTPKEIVESVKPKP--- 1693
             .|.||....|....||       |.:||.||....:...::.:|...:.......|..|.|
Mouse  1080 -LVFPKPMTLRAETSPP-------PVAAKPVALPGSQGTSLNLKTLKTFGAPRPYSSSGPSPFAL 1136

  Fly  1694 ---KNSVSFFVSFDSDDGKPKYKIPKRFQSQSNKNAQKEVKAIEATQSESDIDS----NEEEIEI 1751
               |.|.||..:......:....:|.. .:|..|........:.:...:.|..:    ||...::
Mouse  1137 AVVKRSQSFSKACPESASEGSSALPPA-ATQDEKTHTVNKPTVGSQHGDGDKQNNPVQNEHSSQV 1200

  Fly  1752 IEVSEG----------------DPEY 1761
            :..::|                |||:
Mouse  1201 LTPADGPSFTLKRQSSLTFQSSDPEH 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	67/356 (19%)
Cobll1	XP_006499773.1	Cobl	176..252	CDD:312839	17/124 (14%)
Cobll1	XP_006499773.1	PHA03247	<906..1177	CDD:223021	66/351 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000