DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and COBLL1

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	NP_001265387.1	Gene:	COBLL1 / 22837	HGNCID:	23571	Length:	1233	Species:	Homo sapiens

Alignment Length:	1352	Identity:	282/1352 - (20%)
Similarity:	474/1352 - (35%)	Gaps:	423/1352 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 RKPEIIPKVEDVPKTTPNTKDDEVSGSTEKLEM------NKEEPLDETVELSNHEITLSKVLKTV 810
            |||:     ...|.....||..:||.:.:.:|.      .||..:|:.||||  .:....::|:.
Human    68 RKPK-----AKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVELS--VVLPGDIIKST 125

  Fly   811 SENKQERMEDL-----------PSEDKIVKDSTSSLAEDSKMPEAKKESKSIDELETTKEVLE-- 862
            :.:..:.|.||           ||...|  |..|:.....|.    |.:..|..||..|.:|:
Human   126 TVHGSKPMMDLLIFLCAQYHLNPSSYTI--DLLSAEQNHIKF----KPNTPIGMLEVEKVILKPK 184

  Fly   863 --------DIIHSETDLSKQNIKENVEETDKPQSDDSP-KELENLK---------DKIKMLTQEE 909
                    .||..:|    ..:..|.::|.|.....|| ..|:.|.         |.:..|..::
Human   185 MLDKKKPTPIIPEKT----VRVVINFKKTQKTIVRVSPHASLQELAPIICSKCEFDPLHTLLLKD 245

  Fly   910 VTPIEP----ESLETKGLLSTDKNDKN-----SLFSKTNSEENNNESQNVDDITEKTDLKNEKHL 965
            ....||    :||...||......|.|     ::|||::.:|:...|||:|.:.||.:
Human   246 YQSQEPLDLTKSLNDLGLRELYAMDVNRATSVTVFSKSSLQESCQISQNLDIMKEKEN------- 303

  Fly   966 LASHISVTSSGIDDNDIQNTAASAELSVIDGDISIRESETKHVENREEMASTNLDSDQVENMKLE 1030
                                         .|..|..:...|..:......:|.|
Human   304 -----------------------------KGFFSFFQRSKKKRDQTASAPATPL----------- 328

  Fly  1031 GEIGQLKTVFEQSEEKTSPTKSESLHAEDRKISGKSKESLEDAGDENRAVEEIIDITENDRSTLL 1095
              :.:.:..|.:|...:.|..|.:|.:              ||..:.||
Human   329 --VNKHRPTFTRSNTISKPYISNTLPS--------------DAPKKRRA---------------- 361

  Fly  1096 ENLPSSEKENSTSLDENPLPEKESTSLD-----EKPSSGTEKSTSLDE--KSSSEKEKSTSLDEK 1153
             .||             |:|..:|...|     |:|:|...||.|:||  ||..|..:..:...:
Human   362 -PLP-------------PMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQ 412

  Fly  1154 PSSEKEKSTSLDETPSSEKENSTSLDEKPSPEKES-----TSLDEKPSSGTEKSTSLDEKSSSEK 1213
            .||....::||..|    |..:.|...|..|.:..     |:|  :|..|.... |..|.:|.|:
Human   413 LSSMSAGNSSLRRT----KRKAPSPPSKIPPHQSDENSRVTAL--QPVDGVPPD-SASEANSPEE 470

  Fly  1214 EKSTSLDEKPSSEKEKSTSLNERPSSEKENSTSLVENP-SPEKESTSLDEKPSSGTEKSTSLDEN 1277
            ..|........|.:|:.|:    |...:|  ||:.|.| :||...|||    :||.....||:|
Human   471 LSSPETFHPGLSSQEQCTA----PKLMEE--TSVFECPGTPEAAITSL----TSGISSDYSLEE- 524

  Fly  1278 PSSEKEKSTSLNERPSSEKEN-STSQDEKPSSETEKSTSLDEKPSS---------------EKEK 1326
             ..|||:   |:|.|..|.|| |....:.|...|:...:|...|.|               ||::
Human   525 -IDEKEE---LSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQE 585

  Fly  1327 STSLDGK--------PSSEKEKSTSLDE----NPSSEKEKSTSLNERPSSEKENSTSLVE----N 1375
            :.|.||:        .|:.|:...|:..    .|:.|......:...|.:.::|..:.|:    |
Human   586 TKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVVQNEIIVYPENTEDNMKNGVKKTEIN 650

  Fly  1376 PSPEKESTSLD---EKPSSG----TEKSTSLDEN--------------PSSEKEKSTSLNERPSS 1419
            .....::.::|   |:||:.    |:.:.|..||              ||:||.|..::...||.
Human   651 VEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSC 715

  Fly  1420 EKENSTSQDEKPSSEKEKSTLLDKNTDL--------MRDLIQVSQKVDEEMSKGKAAIAVVD--- 1473
            ...:...||...|..|.:..:...|.::        .:|.:..|:   |..|:|...|...|
Human   716 NSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSR---EFRSQGTLIIHSEDPLT 777

  Fly  1474 -------------LPDINKGES-------VNSPL-------EKKPSSQELEDIQAELS-TDKETG 1510
                         ||.:::.:.       .|.||       :.|||::...:...::. |..:..
Human   778 VKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIV 842

  Fly  1511 EPYNLSAEKHSESET------------SNKPNNTTSKE--IEGEDSR-DHTKVEPI----SKKTI 1556
            .|.:|...|..:|||            ..|..:...||  |:.|||. ..:..||:    .|..:
Human   843 PPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNL 907

  Fly  1557 ETTDVVDVGLKGNDD----PSKPG--KTETAATKSVSPDIKDKDTLKLKPDDDSPQKSEVITAEL 1615
            .|...|...:...||    |.||.  .|....|...:|::::.:.:.     :|..||....|:.
Human   908 RTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNIL-----ESKFKSRASNAQA 967

  Fly  1616 QLKSFKTPND---------DGAWYDIYVEP-----KIT---AERDLFVPPAPIETKRPNSAKEVA 1663
            :..||.....         ..|...::..|     ::|   ||||:.  |:|.:|..|.|  ::.
Human   968 KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDML--PSPEQTLSPLS--KMP 1028

  Fly  1664 SVVEEPMIISERT--------PSYYTPKEIVESVKPKPKNSVSFFVSFDSDDGKPKYKIPKRFQS 1720
            ..|.:|::  |:|        |:..:|..|.    |||                  ..||   .|
Human  1029 HSVPQPLV--EKTDDDVIGQAPAEASPPPIA----PKP------------------VTIP---AS 1066

  Fly  1721 QSNKNAQKEVKAIEATQSESDIDSNEEEIEIIEVSEGDPEYQQTGGTKLQTILELDNENEMTYEF 1785
            |.:....|.:|...|.:..|....:...:.:::.|:...: ::|.......:::
Human  1067 QVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSK-ERTESPSASALVQ----------- 1119

  Fly  1786 NSQGQGLELNLNESNVEKPKSPTNSINEFETAYKTDILNITRSVEIIERAYKRFKNRSSLKSEPG 1850
                       ..:|.|:.|  |:|:|:|     .||..:..|          .|..:|..:|..
Human  1120 -----------PPANTEEGK--THSVNKF-----VDIPQLGVS----------DKENNSAHNEQN 1156

  Fly  1851 NESDFENQNRAAIVIQKWVRNTLKQKAYDTQKSKQSL--------AARKIQR 1894
            ::........:..|::   :::|..::.|.::.:|||        ||.|::|
Human  1157 SQIPTPTDGPSFTVMR---QSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKR 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	96/380 (25%)
COBLL1	NP_001265387.1	UBQ	113..182	CDD:294102	17/76 (22%)
COBLL1	NP_001265387.1	Cobl	197..275	CDD:286545	18/81 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000