DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and Naca

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	NP_001106670.1	Gene:	Naca / 17938	MGIID:	106095	Length:	2187	Species:	Mus musculus

Alignment Length:	1817	Identity:	390/1817 - (21%)
Similarity:	640/1817 - (35%)	Gaps:	526/1817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 ESAIASSNNARNVEKEDEII------PLPKIQNSKSQL-QEISLKNKITPTVSIEIEHVEDILED 623
            ||..:.|.::..|..||.:.      |.|.::.:.:.: ...||:....|.|         |..|
Mouse   518 ESPSSQSASSLEVLSEDTVTKKTTGGPAPVVRPAIAGVATTTSLRADSPPAV---------IRAD 573

  Fly   624 SSASPNDSKADDLTEGISVTE---EPKSIPNVEVDSLKSILINHNLEGCEQETS----------A 675
            |..||| :.:..|..  |||:   .|::..|. ..|..|.|:....|||...:|          :
Mouse   574 SCVSPN-TVSQPLKR--SVTDPAMAPRTAKNT-APSTTSPLVPLASEGCPVASSMALSPQNASVS 634

  Fly   676 ET------------------IVDINFEAAAAKQDIDSNEMIQSSDTHEKIREKRSIEYEDNVQLN 722
            ||                  :.:|:|..|   :.:|:...::||.:..:.....|:..:..|
Mouse   635 ETALALSPEIPKSVPFPDPPLAEISFSNA---RKVDAVSHMESSGSSRQGHPDASVTAKGTV--- 693

  Fly   723 SDSQNVLIAESPIDQEQLKINND---------QTLELDRKPEIIPKVEDVPK--------TTPNT 770
                 |.:|:|.:|.........         ..||:...||....|:. ||        |.|::
Mouse   694 -----VCLADSSLDTSVSASKGSALSGASSPLYPLEVSFLPEAGLAVQG-PKGSLNKLSPTPPSS 752

  Fly   771 KDDEVSGS-------------TEKLEMNKEEPLDETVEL-----SNHEITLSKVLKTVSENKQER 817
            |...|..:             ||....:|:.|    .|:     ...|:|.|:::..|...|.:.
Mouse   753 KGAPVPSTGAPPSPKGAPIVPTESSISSKQVP----AEILPSPQKTPEVTASRLISAVQSPKVDP 813

  Fly   818 -MEDL-PSEDK------IVKDSTSSLAEDS----------KMPEAKKESKSIDELE--------- 855
             |.|: |:..|      :.||::::|:..|          |.|.|.....:|...|
Mouse   814 IMSDVTPTSPKKTSATAVPKDTSATLSLKSVPAVTSLSPPKAPVAPSNEATIVPTEIPTSLKNAL 878

  Fly   856 ---TTKEVLEDIIHSETDLSKQNIKENVEETDKP------------QSDDSPKELENLKDKIKML 905
               |.||.|...|...|..|.|...::|.....|            ..|.||.:...   ::.:|
Mouse   879 AAATPKETLATSIPKVTSPSPQKTPKSVSLKGAPAMTSKKATEIAASKDVSPSQFPK---EVPLL 940

  Fly   906 TQEEVT--PIEPESLETKGLLST-----------------DKNDKNSLFSKTNSEENNNESQNVD 951
            .....|  |..|.|....|.|::                 .|:.|.:...||.:..:......|.
Mouse   941 PHVPPTSPPKSPVSDTLSGALTSPPPKGPPATLAETPTYPKKSPKPAASKKTPATPSPEGVTAVP 1005

  Fly   952 DITEKTDLKNEKHLLASHISVTSSGIDDNDIQNTAASAEL-----SVIDGDISIRESET-KHVEN 1010
            ........|..|.......|.|||   ......||.|.|:     :.:..:||:...|| |....
Mouse  1006 LEIPPCSKKAPKTAAPKESSATSS---SKRAPKTAVSKEIPSKGVTAVPLEISLPLKETSKSATP 1067

  Fly  1011 REEMASTNLDSDQVENMKLEGEIGQLKTV-----FEQSEEKTSPTKSESLHAEDRKISGKS---K 1067
            .|:.||:...|.:....| |...|.:..|     ....|...:.|.:|||.|..:|.|.|:   |
Mouse  1068 GEKSASSPKRSPKTAGPK-ETPPGGVTAVPPEISLPPKETPQNATPNESLAASSQKRSPKTSVPK 1131

  Fly  1068 ES---------LEDAGDENRAVEEIID---ITENDRSTLLENLPSSEKENSTSLDENPLPEKEST 1120
            |:         ||......:|.:..:.   .|..|..|:|...|.|.|:.|.:......|...|.
Mouse  1132 ETPPGGVTAMPLEIPSAPQKAPKTAVPKQIPTPEDAVTILAGSPLSPKKASKTAAPKEAPATPSV 1196

  Fly  1121 SL-----DEKPSSGTEKSTSLDEKSSSEKEKSTSLDEKPSSEKEKSTSLDETPSSEKENSTSLDE 1180
            .:     :..||   .|.||   |:::.||.|.:|   |.....|:.:..|||::..|..|::..
Mouse  1197 GVIAVSGEISPS---PKKTS---KTAAPKENSATL---PPKRSPKTAAPKETPATSSEGVTAVPS 1252

  Fly  1181 K--PSPEKEST--------------SLDEKPSSGTE--KSTSLDEKSS----------------- 1210
            :  |||...::              :|.|.|:|..:  |:.:.:|.|:
Mouse  1253 EISPSPPTPASKGVPVTLTPKGAPNALAESPASPKKVPKTAAPEETSTTPSPQKIPKVAGPKEAS 1317

  Fly  1211 ----SEKEKSTSLDEKPSSEKEKSTS--LNERPSSEKENSTSLVEN---PSPEKESTS---LDEK 1263
                |:|...|::.::.|:..|..|:  |...||..|...|:..:.   ||||..:|:   :...
Mouse  1318 ATPPSKKTPKTAVPKETSAPSEGVTAVPLEIPPSPRKAPKTAAPKETPAPSPEGATTAPVQIPPS 1382

  Fly  1264 PSSGTEKSTSLD--ENPSSE-----------KEKSTSLNERPSSEKENSTSQDEKPSSET--EKS 1313
            |..|::|:.|.:  ..||.|           ..|.||   :.:|.||...:...|..|:|  .|.
Mouse  1383 PRKGSKKAGSKETPTTPSPEGVTAAPLEIPISSKKTS---KMASPKETLVTPSSKKLSQTVGPKE 1444

  Fly  1314 TSLD-------EKPSSEKEKSTSLDGK----PSSEKEKSTSLDENPSSEK----------EKSTS 1357
            |||:       |.|.|.|:...::|.|    ..|.|:..|:|.|:|||.|          |:.|:
Mouse  1445 TSLEGATAVPLEIPPSHKKAPKTVDPKQVPLTPSPKDAPTTLAESPSSPKKAPKTAAPPSERVTT 1509

  Fly  1358 L-NERPSS-EKENSTSL---------------------------VENPSPEKEST---SLDEKPS 1390
            : .|:|:: :|.::|:.                           |:|||..|:::   .|.|.|:
Mouse  1510 VPPEKPATPQKASATTASKVPVPAETQEVAVSSRETPVTPAVPPVKNPSSHKKTSKTIELKEAPA 1574

  Fly  1391 SGTEKSTSLDENPSSEKEKSTSL-NERPSSEK----ENSTSQDEKPSSEKEKSTLLDKNTDLMRD 1450
            :.....|...:.|||:|...||. .|.|:|..    ..|.:|...||.:|..||.:.|.......
Mouse  1575 TLPPSPTKSPKIPSSKKAPRTSAPKEFPASPSIKPVTTSLAQTAPPSLQKAPSTTIPKENLAAPA 1639

  Fly  1451 LIQVSQKVDEEMSKGKAAIA------------VVDLPDINKGESVNSPLEKK--PSSQELEDIQA 1501
            ::.||.|.....:...|:::            ...:|...|..:..:|:|..  ||.:......:
Mouse  1640 VLPVSSKSPAAPAAASASLSPATAAPQTAPKEATTIPSCKKAAATETPIETSTAPSLEGAPKETS 1704

  Fly  1502 ELSTDK--ETGEPYNLSAEKHSESETSN-----------KPNNTTSKEIEGEDSRDHTKVEPISK 1553
            |.|..|  .:..|...|:.|.:.:..:.           .|..|:|    |:||.    :.|:|.
Mouse  1705 ETSVSKVLMSSPPKKASSSKRASTLPATTLPSLKEASVLSPTATSS----GKDSH----ISPVSD 1761

  Fly  1554 --KTIETTDVVDVGLKGNDDPSKPGKTETAATKSVSPDIKDKDTLKLKPDDDSPQKSEVITAELQ 1616
              .|..||......|     |||.|  .||.|:.::.              .:|:.:..|||.:|
Mouse  1762 ACSTGTTTPQASEKL-----PSKKG--PTAFTEMLAA--------------PAPESALAITAPIQ 1805

  Fly  1617 LKSFKTPNDDGAWYDIYVEPK-----------------------ITAERD-------LFVPPAPI 1651
                |:|   ||..:....||                       :..|:|       |.|.||..
Mouse  1806 ----KSP---GANSNSASSPKCPDPSSKKDTKGLPSAVALAPQTVPVEKDTSKAIETLLVSPAKG 1863

  Fly  1652 ETKRPNSAKEVASVVEEPM--IISERTPSYYTPKEIVESVKPKPKNSVSFFVSFDSDDGKPKYKI 1714
            .....:....|.|.|..|:  ..|::.|    |:.:..||.|||..:.|..::.......|
Mouse  1864 SDCLHSPKGPVGSQVATPLAAFTSDKVP----PEAVSASVAPKPAPAASLTLAPSPVAPLP---- 1920

  Fly  1715 PKRFQSQSNKNAQKEVKAIEATQSESDIDSNEEEIEII----EVSEGDPEYQ---------QTGG 1766
            ||:...:|...:..|      :.|:..:.:.|:|:..:    .||.|:| :|         :..|
Mouse  1921 PKQPLLESAPGSVLE------SPSKLPVPAEEDELPPLIPPEAVSGGEP-FQPILVNMPAPKPAG 1978

  Fly  1767 TKL------QTILELDNENEMTYEFNSQGQGLELNLNESNVEKPKSPTNSINEFETAYKTDILNI 1825
            |..      |.:|:           |::|.|.|.:.:||..|..:..:.     :||  |....:
Mouse  1979 TPAPAPSAKQPVLK-----------NNKGSGTESDSDESVPELEEQDST-----QTA--TQQAQL 2025

  Fly  1826 TRSVEIIERAYKRFKNRSSLKSEPGNESDFENQNRAAIVIQKWVRNTLKQKAYDTQKSKQSLAAR 1890
            ..:.||.|....:.|           :|..|.:.|.| :.:..:|..........:|||..|...
Mouse  2026 AAAAEIDEEPVSKAK-----------QSRSEKKARKA-MSKLGLRQVTGVTRVTIRKSKNILFVI 2078

  Fly  1891 KIQRAYR-----RYV----EKAKQRTQKQEMAALIIQKAFIRYSHRIRTEPNKTQSLVNIELKQN 1946
            .....|:     .|:    .|.:..:|:.::||               .|..|.|......:::|
Mouse  2079 TKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAA---------------AEKFKVQGEAVSNIQEN 2128

  Fly  1947 NAAFKIQRAYRRYLKLQSERHQDAGIPVKDDSVSLINSVKLPTEPEIVNKLNSNDEHKVNLI 2008
            .....:|.      :.:.|...:.|:.|||  :.|:.|....:..:.|..|.:|....||.|
Mouse  2129 TQTPTVQE------ESEEEEVDETGVEVKD--IELVMSQANVSRAKAVRALKNNSNDIVNAI 2182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	105/439 (24%)
Naca	NP_001106670.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<2..269	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..196
		PHA03247	<255..689	CDD:223021	40/186 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..370
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..611		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..835		21/100 (21%)
		PHA03247	<762..1251	CDD:223021	112/508 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..1847		227/1017 (22%)
		PHA03247	<1057..1559	CDD:223021	122/514 (24%)
		PHA03247	<1487..1991	CDD:223021	118/554 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1892..2053		42/201 (21%)
		PXLXP	1950..1954		0/3 (0%)
		Required for DNA-binding	2041..2052		4/11 (36%)
		NAC_NACA	2056..2103	CDD:409233	8/46 (17%)
		UBA_NACA_NACP1	2141..2186	CDD:270598	13/44 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000