DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14692 and Cobl

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	XP_011241953.1	Gene:	Cobl / 12808	MGIID:	105056	Length:	1355	Species:	Mus musculus

Alignment Length:	1396	Identity:	272/1396 - (19%)
Similarity:	480/1396 - (34%)	Gaps:	386/1396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 AESPIDQEQLKINNDQTLELDR-----KPEIIPKVEDVPKTTPN--TKDDEVSGSTEKLEMNKEE 788
            |...:..|| |:.:|.||...:     |..:.....|:....|:  .|...||||...:::..|.
Mouse    29 AAQNVHSEQ-KLPHDATLGSQQSLVYMKEALQNSTLDITVVLPSGLEKQSVVSGSHAMMDLLVEL 92

  Fly   789 PLDETVELSNH--EITLSKVLKTVSENKQERMEDLPSEDKIVKDSTSSLAEDSKMPE-------A 844
            .|...:..|:|  ||..|:..:.:|......:..|.....::|:         |:||       .
Mouse    93 CLQNHLNPSHHVLEIWSSETQQPLSFKPNTLIGSLNVHTVLLKE---------KVPEERVKPGLT 148

  Fly   845 KKESKS----IDELETTKEVLE-----------DIIHSETDLSKQNI---KENVE----ETDKPQ 887
            |...||    ::.|.|.|.|:.           .:|.::.:::.:::   ::||.    |..|..
Mouse   149 KAPEKSVRLVVNYLRTQKAVVRVSPEVPLQNILPVICAKCEVNPEHVILLRDNVAGEELELSKSL 213

  Fly   888 SDDSPKELENLKDKIKMLTQEEVTP-IEPESLETKGLLSTDKNDKNSL----FSKTNSEENNNES 947
            ::...|||....::..:||:.:..| :..:.:..|..|..|:.||...    |.|.|...|:.
Mouse   214 NELGIKELYAWDNRRVLLTKTQSEPSLSCQEMFRKSSLGNDETDKEKKKFLGFFKANKRSNSK-- 276

  Fly   948 QNVDDITEKTDLKNEKHLLASHISVTSSGID-DNDIQNTAASAELSVIDGDISIRESETKHVENR 1011
                               |.|:.:  ||.| |.|...:|:..:|   :|.::...|.:.|..:.
Mouse   277 -------------------AEHLGL--SGADSDEDPAKSASGGDL---NGCVTTPNSPSLHSRSL 317

  Fly  1012 EEMASTNLDSDQVENMKLEGEIGQLKTVFEQSEEKTSPTKSESLHAEDRKISGKSKESLEDAGDE 1076
            ....|.:|           |.|..:....:..:.:..|..|..|..:|:.....|..|..|...:
Mouse   318 TLGPSLSL-----------GNISGVSMKSDMKKRRAPPPPSPKLLGQDKVSEKASLSSQADLQKK 371

  Fly  1077 NRAVEEIIDITENDRSTLLENLPSSEKENSTSLDENPLPEKEST-----SLDEKPSSGTEK---- 1132
            .|.........:...|.::.|....::||           ::||     .:.:||..||.:
Mouse   372 KRRAPAPPPPQQPPPSPVVPNRKEDKEEN-----------RKSTVGVGRQVPQKPPRGTARGPPQ 425

  Fly  1133 ------------STSLDE----------KSSSEKEKSTSLDEKPSS------------EKEKSTS 1163
                        .|.:.|          ..:||.....||...|.|            |.|::.|
Mouse   426 LVLPPPPPYPPPDTDVTEPVTFPGEGAGSETSELRPKLSLPLGPGSHCSMGGVSQVPAESEETAS 490

  Fly  1164 LDETPS----SEKENSTSLDEKP----SPEKESTSLDE--------KPSSGTEKSTSLDEKSSSE 1212
            .|.|..    |...::.|||.:.    |.:|.||..::        .|..|.:||.|..:..|..
Mouse   491 EDTTEDSGVMSSPSDAISLDSQQDSMRSKDKWSTDQEDGSDQDLAGTPELGPQKSPSWGKSGSGS 555

  Fly  1213 KEKSTSLDEKPSSEKE----------KSTSLNERPSSEKEN---STSLVENPSPEKESTSLDEK- 1263
            ....|.....|:::.|          ....|:|.....:||   .||.:.|......:.||.|.
Mouse   556 SILRTEKATMPTNDDEDLFITGHLHQTLAELDEDLEGMEENYETDTSSLTNSVNGVSNHSLQEAI 620

  Fly  1264 -PSSGTEKST-----SLDENP------SSEKEKSTSLNERPSSEKENSTSQDEKPSSETEKSTSL 1316
             |.||.:...     .:.:.|      ||....:|:.|....:.:.:..|     .|:||.|
Mouse   621 IPDSGVDDIPVTFIGEVSDEPFDSGLFSSRCNNATTFNTGSIASQRSHLS-----PSQTEHS--- 677

  Fly  1317 DEKP---SSEKEKSTSLDGKPSSEKEK-------STSLDENPSSEKEKSTSLNERPSSEKENSTS 1371
              :|   :|.||...|   .||.:..|       :||.:|||.......|||         .|..
Mouse   678 --QPFVRTSRKEPDPS---PPSQDNRKRNQPTLANTSENENPVETDPTVTSL---------VSKL 728

  Fly  1372 LVENPSPEKE----STSLDEKPSSGTEKSTSLDENPSSEKEKSTSLNERPSSE-----------K 1421
            |:::|..:.:    .:|..||..:| ....||..||...|::|::....|.|.           |
Mouse   729 LIDDPKAKDKGKVHGSSHSEKTQAG-HGINSLRVNPRDGKDESSNSAPPPWSHHGQALGGSYGLK 792

  Fly  1422 ENSTSQDEKPSSEKEKSTLLDKNTDLMRDLIQVSQ---KVDEEMSKGK-----AAIAVVDLPDIN 1478
            ...|:....|  .|.:....|::..|....|::.:   .|...|:..:     :|:...|.|.|.
Mouse   793 YGLTTYKIVP--PKSEMRCYDRDVSLSTGAIKIDELGNLVSPHMNGSRTISPPSAVVETDTPPIG 855

  Fly  1479 KGES----------VNSPLE----KKPSS---------QELEDIQAELSTDKETGEPYNLSAEKH 1520
            |.:.          :|.|.|    :.||:         |:...::|..:......:|.:.....|
Mouse   856 KVKEFWRRNSMEKYLNGPAECTIKRAPSTTITATPEKPQQDNGMKAAFTVTTPQQQPASQEYGAH 920

  Fly  1521 SESETSNKPNN--TTSKEIEGEDSRDHTKVEP---ISKKTIETTDVVDVG-LKGNDDPSKPGKTE 1579
            .|.|.| :|.:  :.|.::...:..|.|.::|   .|.:.:.:.....:| .|.:.|..:|.|
Mouse   921 LEEERS-RPQSAVSCSVKVPASNPTDITFLKPQRRTSSQYVASAIAKKMGPPKVHADVVRPHK-- 982

  Fly  1580 TAATKSVSPDIKDKDTLKLKPDDDSPQ-KSEVITAE--LQLKSFKTPNDDGAWYDIYVEPKI--- 1638
             |.|:....:.|...:...:.||.:|. .||....|  ....|...|::.|........||:
Mouse   983 -ATTEQCHEEAKLARSPPTRKDDAAPNLHSEARQHEHGTNQSSVCLPSNPGVQLPAGGHPKVEVN 1046

  Fly  1639 -------------------------TAERDL--------FVPPAPIETKRPNSAKEVASVVEE-- 1668
                                     ::.||.        |........::.||....:..:::
Mouse  1047 STYGKSSTQDYPAAVHRNSYFLPGRSSHRDRVSVGQSCGFNEKQTTSNQKANSTSNFSQALDKAH 1111

  Fly  1669 --PMIISE-------------RTPSY----YTPKE------IVESVKPKPKNSVSFFVSFDSDDG 1708
              |::::|             |||..    ::|||      |:...:.|| :|:| ....|:||.
Mouse  1112 PPPLLLAEARDSGRILMNGSARTPGNCEPPHSPKESTLTSYIILQTEEKP-SSLS-TDGQDADDT 1174

  Fly  1709 KPK--YKIPKRFQSQSNKNAQKEVKAIEATQSESDIDSNEEEIEIIEV-----SEG---DPEYQQ 1763
            .|.  :...|:|:....:...|:|....|...........|::..:.|     |||   .|.|.:
Mouse  1175 LPSSIFGPKKKFKPVIQRPLPKDVSLHSALMEAIHSSGGREKLRKVNVTAEQTSEGRPKKPSYVE 1239

  Fly  1764 ---------------TGGTKLQTILELDNENEMTYEFNSQG-QGLELNLNES------------N 1800
                           :|...|:.:..|.:|...::...:.| .||:....|.            .
Mouse  1240 AESERSALLAAIRGHSGTLSLRKVSSLASEELQSFRNAALGAPGLDKPQQEDLGLPPPPALPPPP 1304

  Fly  1801 VEKPKSPTNS--INEFETAYKTDILNITRSV 1829
            ...|::|:.|  ::.|.|...::.:|..:::
Mouse  1305 APAPQAPSASVTVSRFSTGTPSNSVNARQAL 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	92/424 (22%)
Cobl	XP_011241953.1	Cobl	152..228	CDD:312839	14/75 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000