DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14692 and RTN3

DIOPT Version :9

Sequence 1:	NP_650019.6	Gene:	CG14692 / 41298	FlyBaseID:	FBgn0037836	Length:	2851	Species:	Drosophila melanogaster
Sequence 2:	XP_011543032.1	Gene:	RTN3 / 10313	HGNCID:	10469	Length:	1037	Species:	Homo sapiens

Alignment Length:	1098	Identity:	224/1098 - (20%)
Similarity:	379/1098 - (34%)	Gaps:	336/1098 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1050 TKSESLHAEDRKISGKSKESLEDAGDENRAVEEIIDITENDRSTLLENLPSSEKENSTSLDENPL 1114
            |||.|....|..:|..|.:.:           .:...::...|:|..:.||||...|:.|..:.:
Human    39 TKSCSSSCADSFVSSSSSQPV-----------SLFSTSQEGLSSLCSDEPSSEIMTSSFLSSSEI 92

  Fly  1115 PEKESTSLDEKPSSGTEKSTSLDEKSSSEKEKSTSLD-------EKP----SSEKEKSTSL---- 1164
            .....|.|.      .|||..|..:....||....||       |||    ::..:.|.||
Human    93 HNTGLTILH------GEKSHVLGSQPILAKEGKDHLDLLDMKKMEKPQGTSNNVSDSSVSLAAGV 151

  Fly  1165 ----DETPSSEKENSTSLDEKPSPEKESTSLDEKPSSGTEKSTSLDEKSSSEKEKSTSLD----- 1220
                ...|:|..|:...|.:|....:|....:.|..:|.           |.:|..|:||
Human   152 HCDRPSIPASFPEHPAFLSKKIGQVEEQIDKETKNPNGV-----------SSREAKTALDADDRF 205

  Fly  1221 -----EKPSSEKEK-----STSLNERPSSEKENSTSLVENPSPE--------------------K 1255
                 :||.:|..|     :.||    |..|.:...::|..|||                    |
Human   206 TLLTAQKPPTEYSKVEGIYTYSL----SPSKVSGDDVIEKDSPESPFEVIIDKAAFDKEFKDSYK 266

  Fly  1256 ESTSLDEKPSSGTEKSTSLDENPSSEK------------------------------EKSTSLNE 1290
            |||......|..|:|.:|.|.:.:::|                              |.|..:|:
Human   267 ESTDDFGSWSVHTDKESSEDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNAALEEVSRCVND 331

  Fly  1291 RPSSEKENST--------SQDEKPSSETEKSTSLD------EKPSSEKEKST-------SLDG-- 1332
            ..:...|..|        .|.:|.|....|:|.||      |.|....:.||       |:||
Human   332 MHNFTNEILTWDLVPQVKQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSIDGST 396

  Fly  1333 ---KPSSEKEKSTSLDENPSSEKEKSTSLNERPSSEKENSTSLVENPSPEKESTSLDEKPSSGTE 1394
               |.:.:..:::...||..:.|....|||    |.||.|...|:. :.:|:..:|.|.|.|..|
Human   397 PITKSTGDWAEASLQQENAITGKPVPDSLN----STKEFSIKGVQG-NMQKQDDTLAELPGSPPE 456

  Fly  1395 KSTSL------------DENPSSEKE-KSTSLNERPSSEKENSTSQDEKPSSEKEKSTLLDKNTD 1446
            |..||            |::...|.: :|::|.|  .:|.::|...|:         |:::   |
Human   457 KCDSLGSGVATVKVVLPDDHLKDEMDWQSSALGE--ITEADSSGESDD---------TVIE---D 507

  Fly  1447 LMRDLIQVSQKVDEE--MSKGKAAI-----AVVDLPDINKGESVNSPLEKKPSSQELEDIQAELS 1504
            :..|....:.|:..|  :|...|.:     .:.::|...:.|..:...|:..|..||...|.::
Human   508 ITADTSFENNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSELHQDQPDI- 571

  Fly  1505 TDKETGEPYNLSAEKHSESETSNKPNNTTSKEIEGEDSRDHTKVEPISKKTIETTDVVDVGLKGN 1569
                      |.....||:..|..|:...|.|                       ||.:|.
Human   572 ----------LGRSPASEAACSKVPDTNVSLE-----------------------DVSEVA---- 599

  Fly  1570 DDPSKPGKTETAATKS-VSPDIKDKDTLKLKPDDDSPQKSEVITAELQLKSFKTPN----DDGAW 1629
              |.||..||.....| |||::.::....|.           :|....|:|....|    ||.:.
Human   600 --PEKPITTENPKLPSTVSPNVFNETEFSLN-----------VTTSAYLESLHGKNVKHIDDSSP 651

  Fly  1630 YDIYVEPKITAERDLFVPPAPIETKRPNSAKEVASVVEEPMIISERTPSYYTPKEIVESVKPKPK 1694
            .|:..  ..|..||..:    ::::| |:.|    .:.|.|...:.||    |.|::.
Human   652 EDLIA--AFTETRDKGI----VDSER-NAFK----AISEKMTDFKTTP----PVEVLH------- 694

  Fly  1695 NSVSFFVSFDSDDGKPKYK-IPKRFQSQSNKNAQKEVKAIEATQSE--SDIDSNEEEIEIIEVSE 1756
                     :::.|..:.| |..::..||.:....|...:..||..  :.:|..:|::.|..:.|
Human   695 ---------ENESGGSEIKDIGSKYSEQSKETNGSEPLGVFPTQGTPVASLDLEQEQLTIKALKE 750

  Fly  1757 -GDPEYQQTGGTKLQTILELDNENEMTYEFNSQGQG--------LELNL-NESNVEKPKSP---- 1807
             |:.:.:::  |..|...||.:|..:...|....:.        ||.|: |.|::...:.|
Human   751 LGERQVEKS--TSAQRDAELPSEEVLKQTFTFAPESWPQRSYDILERNVKNGSDLGISQKPITIR 813

  Fly  1808 -TNSINEFETAYKTDILNITRSVEIIERAYKRFKNRSSLKSEPGNESDFENQNRAAIVIQKWVRN 1871
             |..::...:..||:::    ...::.|....|.....:......::.|.......:::.....:
Human   814 ETTRVDAVSSLSKTELV----KKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFS 874

  Fly  1872 TLKQKAYDTQKSKQSLAARKIQRAYRRYVEKAKQRTQKQEMAALIIQKAFIRYSHRIRTEPNKTQ 1936
            .:...:|      ..||...:..::|.| :...|..||.|                 ...|.|..
Human   875 VISVVSY------LILALLSVTISFRIY-KSVIQAVQKSE-----------------EGHPFKAY 915

  Fly  1937 SLVNIELK-------QNNAAFKIQRAYRRYLKLQSERHQDAGIPVKDDSVSLINSVKL 1987
            ..|:|.|.       .|.|...|.||.:..::|         ..|:|    |::|:||
Human   916 LDVDITLSSEAFHNYMNAAMVHINRALKLIIRL---------FLVED----LVDSLKL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14692	NP_650019.6	DD_R_PKA	9..43	CDD:295380
		DD_R_PKA	82..120	CDD:295380
		LRIF1	<1113..1428	CDD:292369	98/437 (22%)
RTN3	XP_011543032.1	Reticulon	844..999	CDD:280592	27/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000