DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM3

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_010882.1	Gene:	MCM3 / 856680	SGDID:	S000000758	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	830	Identity:	244/830 - (29%)
Similarity:	376/830 - (45%)	Gaps:	198/830 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GFD-DAGVFFS-DNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLK---------- 55
            ||| ||..||: |...||.           .::::||:.||.      .|||:::
Yeast     6 GFDGDATTFFAPDAVFGDR-----------VRRFQEFLDTFT------SYRDSVRSIQVYNSNNA 53

  Fly    56 RNYLNGR---------------------------------YFLEIEMEDLVGFDETLADKLNKQP 87
            .||.:.:                                 :.:.|.::||..||.:....:..:|
Yeast    54 ANYNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEP 118

  Fly    88 TEHLEIFEEAAREVADEI-TAPRPE----HEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIA 147
            ...:...|:|..::||.: ..|.|.    ...|...:....|..|:..:.|.|.:..::|||.:.
Yeast   119 AYFIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVE 183

  Fly   148 GIIVAASGI----------SAKATRMSIQ-----CLSCSTVIPNLKVNP--GLEGYALPRKCNTE 195
            ||:...|.:          :||..|...:     ..:.:|.||...:.|  ..||    .|..||
Yeast   184 GIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEG----NKLTTE 244

  Fly   196 QAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLI 260
            ..      ...|         :|.|.:.:||:|:..|.|::||.:.:..|..|.::..||:||.:
Yeast   245 YG------YSTF---------IDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNV 294

  Fly   261 QGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITV---DSEGAGAISRYSNITSDEEEHFRRM 322
            .|::  :.:|...........::|.:.   .::|.||   .:...|..:| ..:|..:..:..::
Yeast   295 VGVF--KSLGAGGMNQSNSNTLIGFKT---LILGNTVYPLHARSTGVAAR-QMLTDFDIRNINKL 353

  Fly   323 AASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQL 387
            :...||::.|||||||||:|...|||||..||.||..|.|.:|...|||||:|::|||.||||||
Yeast   354 SKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQL 418

  Fly   388 LKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDR 452
            |:||...|.:|:.|:|:|||..||||:|..|.:|....:|.|||||||.|||||||||||.:.||
Yeast   419 LRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDR 483

  Fly   453 VAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFI 516
            |||||.|||||::||||||.||||:||||:||||.:||::|..:. .:||....::|||||::|:
Yeast   484 VAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFV 548

  Fly   517 VKDIHDESRDITLAKHIINVH--------------------LSSNKSAPSEPA-----------E 550
            |.|..:|.||.::::|::..|                    |:..:.|...|.           |
Yeast   549 VTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENE 613

  Fly   551 GE-----------------------------------ISLSTFKKYIHYCRTHCGPRLSEAAGEK 580
            ||                                   :::...:||:.|.:....|:|::.|...
Yeast   614 GEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINV 678

  Fly   581 LKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQV 645
            :...|..:|:        .|.....|||.|.||.:||::.:.||:||     .:.||:.......
Yeast   679 IVKNYTDLRN--------DDNTKKSPITARTLETLIRLATAHAKVRL-----SKTVNKVDAKVAA 730

  Fly   646 STLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQ 695
            :.|..|:.|...|.:  ..||:.|    .|:.|.:|....|....|.:.|
Yeast   731 NLLRFALLGEDIGND--IDEEESE----YEEALSKRSPQKSPKKRQRVRQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	22/140 (16%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	197/606 (33%)
MCM3	NP_010882.1	MCM_N	25..>137	CDD:405270	19/117 (16%)
MCM3	NP_010882.1	MCM	166..738	CDD:214631	199/609 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810