DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM7

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_009761.4	Gene:	MCM7 / 852501	SGDID:	S000000406	Length:	845	Species:	Saccharomyces cerevisiae

Alignment Length:	752	Identity:	249/752 - (33%)
Similarity:	377/752 - (50%)	Gaps:	99/752 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTF-----------NEENFFYKYRDTLKRNY 58
            ||...:.::.|....|.|..::  |:::....|...|           .:|   ..|:|.:....
Yeast    83 DDILQYQNEKFLQGTQADDLVS--AIQQNANHFTELFCRAIDNNMPLPTKE---IDYKDDVLDVI 142

  Fly    59 LNGRYFLEIEMEDLVGFDETLADKLNKQPTEHL--------EIFEEAAREVADEITAPRPEHEEH 115
            ||.|......|         |:|:.|:..:|:|        ....:|.|||.::.|...|.:...
Yeast   143 LNQRRLRNERM---------LSDRTNEIRSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTR 198

  Fly   116 MHDIQIL-LSSN-----------ANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCL 168
            .:.:... ||.|           :.|.::||:|.|.:.:|:.:.|||...|.:......::..|.
Yeast   199 RYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCD 263

  Fly   169 SCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQ 233
            .|...:.. :||.  ..:....:|.:|:..:.:.. ...|:.....|...||..|:|||...||.
Yeast   264 QCGYEVFQ-EVNS--RTFTPLSECTSEECSQNQTK-GQLFMSTRASKFSAFQECKIQELSQQVPV 324

  Fly   234 GEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVG-VRAPYMRVVGITV 297
            |.|||.|.:..:.:|...:.||:.|.:.||:      .|:...|.:....| :...|:....:..
Yeast   325 GHIPRSLNIHVNGTLVRSLSPGDIVDVTGIF------LPAPYTGFKALKAGLLTETYLEAQFVRQ 383

  Fly   298 DSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL 362
            ..:...:.|    :|||.||....:..|||:|.||::|:||.|:|:.|:|||:..:|.||..||:
Yeast   384 HKKKFASFS----LTSDVEERVMELITSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRV 444

  Fly   363 PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVME 427
            .||:..||||||.|:||||.|||||||.:.|::|..|||:|||||..||||:|||||.|...::|
Yeast   445 GDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILE 509

  Fly   428 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRW 492
            |||:||||.|:.||||||||.|.||.||||.||||||||:||||.||||:|.|:|||||.::||:
Yeast   510 GGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRY 574

  Fly   493 DDTKGE-ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKS----APSEPAEGE 552
            :..... :||:....:|||||::|::.||.....|..||:|:..||:.:.:.    .|.||
Yeast   575 NPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEP---- 635

  Fly   553 ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSI-PITVRQLEAVI 616
               |..::||.|.:|. .|.:|||..:.:...|:.:|.   ..::..|.:.|. ..|.|.|..:|
Yeast   636 ---SKMREYIAYAKTK-RPVMSEAVNDYVVQAYIRLRQ---DSKREMDSKFSFGQATPRTLLGII 693

  Fly   617 RISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRR 681
            |:|::|||:||......:.|.|||||.:||......       |...::||:....:|...:|:.
Yeast   694 RLSQALAKLRLADMVDIDDVEEALRLVRVSKESLYQ-------ETNKSKEDESPTTKIFTIIKKM 751

  Fly   682 FAIGSQVSEQNILQDFLRQKYEERTVMKVIHTMIRRG 718
            .    |.:.:|.|      .||     .::.|:..||
Yeast   752 L----QETGKNTL------SYE-----NIVKTVRLRG 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	20/112 (18%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	207/526 (39%)
MCM7	NP_009761.4	MCM_N	52..>123	CDD:405270	8/41 (20%)
MCM7	NP_009761.4	MCM	223..724	CDD:214631	206/525 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810