DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM5

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_013376.1	Gene:	MCM5 / 850980	SGDID:	S000004264	Length:	775	Species:	Saccharomyces cerevisiae

Alignment Length:	778	Identity:	369/778 - (47%)
Similarity:	497/778 - (63%)	Gaps:	58/778 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIE 68
            ||...::.:....|::..|.. |.:.: |.:|.||..|..::.|. |||.|:.|.|...|.|.:.
Yeast     3 FDRPEIYSAPVLQGESPNDDD-NTEII-KSFKNFILEFRLDSQFI-YRDQLRNNILVKNYSLTVN 64

  Fly    69 MEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITA-----------PRPEHEEHMHD---- 118
            ||.|:|::|.:..||:.:|::.:.:||.|..:||..|:.           ..||:.....|
Yeast    65 MEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLL 129

  Fly   119 -----IQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSC----STVI 174
                 .|::|:||||...:|.|.|:.|||:|:::|||::.|.:|::||.:||.|.:|    |..|
Yeast   130 NSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITI 194

  Fly   175 PNLKVNPGLEGYALPRKCNT---------------EQAGRPKCPLDPFFIMPDKCKCVDFQTLKL 224
            .|.....| ...:|||.|.:               :::.:..|..||:.|:.:..|.:|.|.|||
Yeast   195 NNFNSITG-NTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKL 258

  Fly   225 QELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSI--RKVGKPSRRD--GREKAVVGV 285
            ||:|:.||.||:||:|.:.|||.|..:|:||.||.|.|||||  .|.|..|.|.  |...:.|.:
Yeast   259 QEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAI 323

  Fly   286 RAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAI 350
            |.||::::||..|.|.:...:..:..|.:|||.|.:::.:..:||.|:.|:||||||:.||||||
Yeast   324 RTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKKAI 388

  Fly   351 TCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASV 415
            .|:|.|||:|.||||:..||||||||||||||||||||||||||:||||||||||||||||||||
Yeast   389 VCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASV 453

  Fly   416 MKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCS 480
            .:||.||.|.:||||||||||||||||||||||::|||||||||||||||||||||||.||||.|
Yeast   454 QRDPMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTS 518

  Fly   481 VLAAANSIFGRWDDTKGE-ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSA 544
            ||||||.|:||:||.|.. :||||..||||||||||||||.|:|.|||::|.|:||:|..:..:.
Yeast   519 VLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAM 583

  Fly   545 PSEPAE--GEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPI 607
            .::..|  .|||:...|:||.|||..|.||||..|.|||.|.:|.:|......|..|.:|.||||
Yeast   584 QNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPI 648

  Fly   608 TVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAM---TGSLAGAEGFTTEEDQE 669
            |:|||||:|||:|||||:.|.|.|.:.||:||:||||.||:|||.   .|.|..|.|.:..|
Yeast   649 TIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSE--- 710

  Fly   670 TLNRIEKQLKRRFAIGSQVSEQNILQDFL-RQKYEERTVMKVIHTMIRRGELQHRMQRKMLYR 731
             :.|.|::||||..||...|.|.:.::|: ..::.:..:.|.::.:.:...:|.|.|.:.:||
Yeast   711 -IRRFEQELKRRLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYR 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	32/112 (29%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	302/545 (55%)
MCM5	NP_013376.1	MCM_N	29..>101	CDD:405270	27/72 (38%)
MCM5	NP_013376.1	MCM	144..689	CDD:214631	302/545 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346382
Domainoid	1	1.000	337	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4904
Inparanoid	1	1.050	634	1.000	Inparanoid score	I117
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53983
OrthoFinder	1	1.000	-	-		FOG0004690
OrthoInspector	1	1.000	-	-		oto99078
orthoMCL	1	0.900	-	-		OOG6_102165
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R695
SonicParanoid	1	1.000	-	-		X3292
TreeFam	1	0.960	-	-
	15	14.790