DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcm5 and MCM8

DIOPT Version :9

Sequence 1:NP_524308.2 Gene:Mcm5 / 41296 FlyBaseID:FBgn0017577 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_001268450.1 Gene:MCM8 / 84515 HGNCID:16147 Length:880 Species:Homo sapiens


Alignment Length:801 Identity:214/801 - (26%)
Similarity:350/801 - (43%) Gaps:174/801 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 EFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDET------LADKLNKQPTEHLEIF 94
            |.|:.|  |.||.::.|...::.:..:..:.::.::|....|.      :|.:|...|.:.|...
Human    94 EKIQAF--EKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACM 156

  Fly    95 EEAAREVADEITAPRPEHEEHMHDIQIL--LSS----------------NANP-TNIRQLKSDCV 140
            ..|..:|..:      :.|.|..::|..  ||:                |..| |.::.::::..
Human   157 GLAIHQVLTK------DLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYY 215

  Fly   141 SKLVKIAGIIVAASGISAKATRMSIQCLSCSTV----IPNLKVNPGLEGYALPRKCNTEQAGRPK 201
            .|.:.:.|.:|..|.|....|:|:..|.:|..:    :|:.|       |:||.||..     |.
Human   216 GKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGK-------YSLPTKCPV-----PV 268

  Fly   202 CPLDPFFIMPDKCKCV--DFQTLKLQEL--PDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG 262
            |....|..:......|  |:|::|:|||  .|....|.|||.::......|.:..|||:.|.|.|
Human   269 CRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITG 333

  Fly   263 IYSIRKVGKPSR----------------------------RDGREK------------AVVGVRA 287
            |..:....:.||                            .||.:.            |:..::|
Human   334 IVKVSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQA 398

  Fly   288 P---YMRVV----GITVDSEGAGAISRYSNI----TSDEEEHFRRMAASGDIYERLSQSLAPSIF 341
            .   :..:|    .::...|.:||||.:.|:    ::.......|:|.:..:..:....|.    
Human   399 EENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLL---- 459

  Fly   342 GSRDIKKAITCMLFGGSRK------RLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVY 400
                :|..:...|||||:|      |:|    .|||.::|::||||..|||:|:....|||..||
Human   460 ----VKAGLALALFGGSQKYADDKNRIP----IRGDPHILVVGDPGLGKSQMLQAACNVAPRGVY 516

  Fly   401 TSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTIS 465
            ..|..::.:|||.::.||..:.:|.:|.||:||.|.|:..|||||||....: |:.||||||:||
Human   517 VCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSIS 580

  Fly   466 IAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITL 529
            :||||:..:|.:|.|::||||.:.|.::..|. .||:.....:|||||::||:.|..:|..|..|
Human   581 LAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLL 645

  Fly   530 AKHIINVHLSSNKSAPSE------------------------------PAE--GEISLSTFKKYI 562
            ::|:|.:.....::..|.                              |.|  ..|.....:|||
Human   646 SEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYI 710

  Fly   563 HYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRL 627
            .|.|.:..||||..|...|:..|:.:|       |.|.:..|.|||.||||::||::|:.|::.|
Human   711 GYARQYVYPRLSTEAARVLQDFYLELR-------KQSQRLNSSPITTRQLESLIRLTEARARLEL 768

  Fly   628 QPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEG-FTTEEDQETLNRIEKQLKRRFAIG-SQVSE 690
            :..||.|...:.:.:.:.|     |.|:.:...| ...|..|.......:...:||... :.|:|
Human   769 REEATKEDAEDIVEIMKYS-----MLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAE 828

  Fly   691 Q---NILQ-DFLRQKYEERTV 707
            :   ||.| ..|||..:|..:
Human   829 RTYNNIFQFHQLRQIAKELNI 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm5NP_524308.2 MCM_N 31..124 CDD:405270 18/95 (19%)
MCM 128..648 CDD:214631 177/618 (29%)
MCM8NP_001268450.1 MCM_N 98..223 CDD:291233 22/132 (17%)
Mcm2 139..877 CDD:224162 205/754 (27%)
AAA 475..633 CDD:99707 70/162 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D232729at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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