Protein Alignment Mcm5 and MCM8

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001268450.1
• Gene: MCM8 / 84515
• HGNCID: 16147
• Length: 880
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 219/797 - (27%)
• Similarity: 348/797 - (43%)
• Gaps: 166/797 - (20%)

  Fly    36 EFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDET------LADKLNKQPTEHLEIF 94
            |.|:.|  |.||.::.|...::.:..:..:.::.::|....|.      :|.:|...|.:.|...
Human    94 EKIQAF--EKFFTRHIDLYDKDEIERKGSILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACM 156

  Fly    95 EEAAREVADEITAPRPEHEEHMHDIQIL--LSS----------------NANP-TNIRQLKSDCV 140
            ..|..:|..:      :.|.|..::|..  ||:                |..| |.::.::::..
Human   157 GLAIHQVLTK------DLERHAAELQAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYY 215

  Fly   141 SKLVKIAGIIVAASGISAKATRMSIQCLSCSTV----IPNLKVNPGLEGYALPRKCNTEQAGRPK 201
            .|.:.:.|.:|..|.|....|:|:..|.:|..:    :|:.|       |:||.||..     |.
Human   216 GKYIALRGTVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGK-------YSLPTKCPV-----PV 268

  Fly   202 CPLDPFFIMPDKCKCV--DFQTLKLQEL--PDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG 262
            |....|..:......|  |:|::|:|||  .|....|.|||.::......|.:..|||:.|.|.|
Human   269 CRGRSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITG 333

  Fly   263 IYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGI-------TVDSEGA---GAISRYS-------N 310
            |..:....:.| |:..:|.:..:   |:....|       |..||..   |.:..:|       .
Human   334 IVKVSNAEEGS-RNKNDKCMFLL---YIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQ 394

  Fly   311 ITSDEEEHFR-----------RMAASGDIYERLSQSLAPS------------IFGSRD------- 345
            ....||..|:           |:..||.|....:..|..|            ..|.|.
Human   395 EIQAEENLFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLL 459

  Fly   346 IKKAITCMLFGGSRK------RLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGK 404
            :|..:...|||||:|      |:|    .|||.::|::||||..|||:|:....|||..||..|.
Human   460 VKAGLALALFGGSQKYADDKNRIP----IRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGN 520

  Fly   405 GSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 469
            .::.:|||.::.||..:.:|.:|.||:||.|.|:..|||||||....: |:.||||||:||:|||
Human   521 TTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKA 584

  Fly   470 GITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHI 533
            |:..:|.:|.|::||||.:.|.::..|. .||:.....:|||||::||:.|..:|..|..|::|:
Human   585 GVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHV 649

  Fly   534 INVHLSSNKSAPSE------------------------------PAE--GEISLSTFKKYIHYCR 566
            |.:.....::..|.                              |.|  ..|.....:|||.|.|
Human   650 IAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPHQLLRKYIGYAR 714

  Fly   567 THCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFA 631
            .:..||||..|...|:..|:.:|       |.|.:..|.|||.||||::||::|:.|::.|:..|
Human   715 QYVYPRLSTEAARVLQDFYLELR-------KQSQRLNSSPITTRQLESLIRLTEARARLELREEA 772

  Fly   632 TDEHVNEALRLFQVSTLDAAMTGSLAGAEG-FTTEEDQETLNRIEKQLKRRFAIG-SQVSEQ--- 691
            |.|...:.:.:.:.|     |.|:.:...| ...|..|.......:...:||... :.|:|:
Human   773 TKEDAEDIVEIMKYS-----MLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNNVAERTYN 832

  Fly   692 NILQ-DFLRQKYEERTV 707
            ||.| ..|||..:|..:
Human   833 NIFQFHQLRQIAKELNI 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	19/96 (20%)
		MCM	128..648	CDD:214631	182/614 (30%)
MCM8	NP_001268450.1	Mcm2	88..877	CDD:440854	219/797 (27%)