DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM6

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001331629.1	Gene:	MCM6 / 834492	AraportID:	AT5G44635	Length:	857	Species:	Arabidopsis thaliana

Alignment Length:	813	Identity:	238/813 - (29%)
Similarity:	385/813 - (47%)	Gaps:	147/813 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FGGDNQQDAQINLQAVKKKYKEFIRTF----NEENFFYKYR-DTLKRNYLNGRYFLEIEMEDLVG 74
            |||....:..|.::.|   :.||:::|    |:...:|:.. :.::.......|   |:...::|
plant     4 FGGFVMDEQAIQVENV---FLEFLKSFRLDANKPELYYEAEIEAIRGGESTMMY---IDFSHVMG 62

  Fly    75 FDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDC 139
            |::.|...:..:..........|.:....|:.......:....||.:...:......:|:|.:..
plant    63 FNDALQKAIADEYLRFEPYLRNACKRFVIEMNPSFISDDTPNKDINVSFYNLPFTKRLRELTTAE 127

  Fly   140 VSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQAGRPKCPL 204
            :.|||.:.|::...|.:..:....:.:||.|.:||.|::..   ..|..|..|.:     |.| |
plant   128 IGKLVSVTGVVTRTSEVRPELLYGTFKCLDCGSVIKNVEQQ---FKYTQPTICVS-----PTC-L 183

  Fly   205 D--PFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG----I 263
            :  .:.::..:.|..|:|.:::||....:|.|.:||.|.:.....:.|:...|:.|:..|    |
plant   184 NRARWALLRQESKFADWQRVRMQETSKEIPAGSLPRSLDVILRHEIVEQARAGDTVIFTGTVVVI 248

  Fly   264 YSIRKVGKPS-----RRDGRE--------KAVVGVRAPYMR-----------VVGITVDSEGAGA 304
            ..|..:..|.     |||..:        :.|.|::|..:|           .|.|...|.....
plant   249 PDISALAAPGERAECRRDSSQQKSSTAGHEGVQGLKALGVRDLSYRLAFIANSVQIADGSRNTDM 313

  Fly   305 ISRYSNITSDEEEHF--------RRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKR 361
            .:|.::...|:::.|        ::|..:.|.:.:|..|:||::||.:|||:|:..||.||..|.
plant   314 RNRQNDSNEDDQQQFTAEELDEIQQMRNTPDYFNKLVGSMAPTVFGHQDIKRAVLLMLLGGVHKT 378

  Fly   362 LPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVM 426
            ..:|:..||||||.::|||..||||.||:...:.|.:||||||.||||||||:|.|:|:|..|.:
plant   379 THEGINLRGDINVCIVGDPSCAKSQFLKYTAGIVPRSVYTSGKSSSAAGLTATVAKEPETGEFCI 443

  Fly   427 EGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGR 491
            |.||::|||.|:.||||||||...|:||||||||||||||.||||..|||:|.|:|||||.:.||
plant   444 EAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGR 508

  Fly   492 WDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISL 555
            :|.:|. :.|::..|.||||||:::::.|..||..|..:|.||:.||  ....|...|   |.:.
plant   509 YDKSKPLKYNVNLPPAILSRFDLVYVMIDDPDEVTDYHIAHHIVRVH--QKHEAALSP---EFTT 568

  Fly   556 STFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISE 620
            ...|:||.|.:| ..|:||..|.:.|...||.:|.|    :.....|::..:|||||||:||:||
plant   569 VQLKRYIAYAKT-LKPKLSPEARKLLVESYVALRRG----DTTPGTRVAYRMTVRQLEALIRLSE 628

  Fly   621 SLAKIRLQPFATDEHVNEALRLFQVSTLD------------------------------------ 649
            ::|:..|:......||..|:||.:.|.:.
plant   629 AIARSHLEILVKPSHVLLAVRLLKTSVISVESGDIDLSEYQDANGDNMDDTDDIENPVDGEEDQQ 693

  Fly   650 -------AAMTGSLAGAEGFTTEED----------------QETLNRIEKQL------------- 678
                   :|...:.|.|:.....|:                :||:|:..||.
plant   694 NGAAEPASATADNGAAAQKLVISEEEYDRITQALVIRLRQHEETVNKDSKQQHSSIFHTFHFLSS 758

  Fly   679 ---KRRFAIGSQ---VSEQNILQDFLRQKYEER 705
               ...|.:||:   :.::.:::.|:.|:.|::
plant   759 TIENNFFPLGSELPGIRQKELIRWFIDQQNEKK 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	14/97 (14%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	204/558 (37%)
MCM6	NP_001331629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820