DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM8

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001319512.1	Gene:	MCM8 / 820123	AraportID:	AT3G09660	Length:	801	Species:	Arabidopsis thaliana

Alignment Length:	807	Identity:	222/807 - (27%)
Similarity:	367/807 - (45%)	Gaps:	182/807 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GFDDAG------VFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLN- 60
            |.|..|      |:..||   :|....:..||..    .|.||.|:..    ..||.:.:  :|
plant    18 GIDSLGIGKILAVYIKDN---ENLAIDEDKLQLT----AELIRVFSAS----PGRDIVSQ--VNE 69

  Fly    61 ---GRYFLEIEME------DLVGFDETLADKLNKQPTEHLEIFEEAAREV------ADEITAPRP 110
               |.:.|.::::      |:..|...|.|    .|...:.....|..:|      .:|.
plant    70 DGGGSFSLSLDLQQFKKISDIENFFINLED----NPKGVIPCMNAAVHKVLFDQWETNEF----- 125

  Fly   111 EHEEHMHDIQILLSSNANPT-NIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI 174
               |::..|.:.|.:....: :::.|::..:.|||.:.|.:|..|.:....|:|:..|..|.|.|
plant   126 ---ENVMKINVRLHNYPESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGKCKTGI 187

  Fly   175 ----PNLKVNPGLEGYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQEL--PDFVPQ 233
                .:.|.:|       |.||::.     .|....|..:....:.:|||.:::|||  |:...:
plant   188 TREFTDGKFSP-------PLKCDSH-----GCKSKTFTPIRSSAQTIDFQKIRVQELQKPEDHEE 240

  Fly   234 GEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVD 298
            |.:||.::......|.:..:||:.|.:.||                   :||...||.:.|....
plant   241 GRVPRTVECELMEDLVDICIPGDVVTVTGI-------------------IGVINNYMDIGGGKSK 286

  Fly   299 SEGAG-------AIS-----RYSNITSDEEEHFRRMAAS-GDIY--------------------- 329
            ::..|       |:|     |.|...:.|:.......|. ||:|
plant   287 TKNQGFYYLFIEAVSVKNTKRQSAFENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDT 351

  Fly   330 -ERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPD--GLCRRGDINVLLLGDPGTAKSQLLKFV 391
             .|:..|:.|||:|...:|..||..||||.||...|  .:..||||:|:::||||..|||||:..
plant   352 FRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHSMDRNKVPVRGDIHVIIVGDPGLGKSQLLQAA 416

  Fly   392 EKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIH 456
            ..::|..:|..|..::.||||.:|:||..|.::..|.|||||||||:.||||||||..:.: |:.
plant   417 AAISPRGIYVCGNATTRAGLTVAVVKDSMTNDYAFEAGAMVLADGGLCCIDEFDKMTTEHQ-ALL 480

  Fly   457 EAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDI 520
            ||||||.:|:||||:..:|::|.||:||||.:.|.::..|. .||:.....:|||||::||:.|.
plant   481 EAMEQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDK 545

  Fly   521 HDESRDITLAKHIINVHLSSNKSAPS----EP--------------AEGEISLS----------- 556
            .||..|..:::||:::|.:|.:::|:    :|              |||...||
plant   546 PDELLDKQVSEHIMSLHSASGETSPALKKFKPVNAASQNAGYANMHAEGNSLLSRLRLDSEKDDD 610

  Fly   557 -------TFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEA 614
                   ..:|||.|.|....|::|:.|||.::..|:.:|    ....::|   |.|||.||||:
plant   611 FSPVPGQLLRKYISYARNFVNPKMSKDAGEIIQKFYLKLR----DHNTSAD---STPITARQLES 668

  Fly   615 VIRISESLAKIRLQPFATDEHVNEALRLFQVS----------TLDAAMTGSLAGAEGFTTEEDQE 669
            ::|::::.|::.|:...|.:...:.:.:.:.|          .:|...:|.::     ..:|.:.
plant   669 LVRLAQARARVDLREEITVQDAMDVVEIMKESLYDKLIDEHGVVDFGRSGGMS-----QQKEAKR 728

  Fly   670 TLNRIEKQLKRRFAIGSQVSEQNILQD 696
            .|:.::||.:.:......|||...|.|
plant   729 FLSALDKQSELQQKDCFSVSEMYSLAD 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	19/108 (18%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	182/610 (30%)
MCM8	NP_001319512.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820