Protein Alignment Mcm5 and Mcm9

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_082106.3
• Gene: Mcm9 / 71567
• MGIID: 1918817
• Length: 1134
• Species: Mus musculus
• Alignment Length: 726
• Identity: 210/726 - (28%)
• Similarity: 340/726 - (46%)
• Gaps: 106/726 - (14%)

  Fly    24 QINLQAVKKKYKEFIRTFNEEN--FFYKYRDTLKRNY---LNGRYFLEIEMEDLVGFDETLADKL 83
            |:.|  |.:.::.::..:::.:  ...|.||. ..:|   :|.....|..||        :.|..
Mouse     5 QVTL--VGQVFESYVSEYHKNDILLILKERDE-DAHYPVVVNAMSLFETNME--------IGDYF 58

  Fly    84 NKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNAN-----------PTNIRQ--L 135
            ...|.|.|.:|:.|.|..|..|....||.|.        ||...|           |..:|:  .
Mouse    59 TVFPNEVLTVFDSALRRSALAILQSLPETEG--------LSMKQNLHARISGLPVCPELVREHIP 115

  Fly   136 KSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGY---ALPRKCNTEQA 197
            |:..|...:.:.|.::..|.:..........|..|..|   ..|....|.|   :.|..|    .
Mouse   116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHV---FMVEADFEQYYTFSRPSSC----P 173

  Fly   198 GRPKCPLDPFFIMPD----KCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRV 258
            ....|....|..:.|    ..:|.|:|.:|:||....:..|.|||.:::..:..|.:....|:.:
Mouse   174 SLASCDSSKFSCLSDLSSSPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDL 238

  Fly   259 LIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEE------- 316
            .|.|:  :.:..||.:||.|.:..:.::|.|     :.|::|      :.|.:..||:
Mouse   239 TIYGV--VMQRWKPFQRDVRCEVEIVLKANY-----VQVNNE------QSSGMVMDEDTRKEFED 290

  Fly   317 --EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGD 379
              ||::....:|  ...:..||.|.:||...:|.|:..:|.||.::....|...||:.::||:||
Mouse   291 FWEHYKSDPFAG--RNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGD 353

  Fly   380 PGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEF 444
            |||.|||.||:..|:.|.:|.|:|.||::||||.:.:||....|  :|.||:||||.|:.|||||
Mouse   354 PGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWN--LEAGALVLADAGLCCIDEF 416

  Fly   445 DKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTIL 508
            :.::|.||.:|||||||||||:||||:...||:|.::|||.|. .|::|..:. ..||.....:|
Mouse   417 NSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPKESVSVNIALGSPLL 480

  Fly   509 SRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRL 573
            ||||::.::.|..:|..|     .||:..:..||..||: :|...|:...|.|....| :..|.|
Mouse   481 SRFDLVLVLLDTRNEDWD-----RIISSFILENKGYPSK-SENLWSMEKMKTYFCLIR-NLHPTL 538

  Fly   574 SEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNE 638
            ||.:.:.|...|        |.::.||.|.:...|:|.||::||::|:.|::..:...|.|....
Mouse   539 SEVSNQVLLRYY--------QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVT 595

  Fly   639 ALRLFQVSTLDAAMTGS--LAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQK 701
            |     ||.::::|.|.  |.|.....|...:....:.::|.:   .|..::..|.:||:.||:.
Mouse   596 A-----VSVMESSMQGGALLGGVNALHTSFPENPRAQYQRQCE---LILEKLELQGLLQEELRRL 652

  Fly   702 YEERTVMKVIH 712
              ||...:.:|
Mouse   653 --ERLQNESVH 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	21/98 (21%)
		MCM	128..648	CDD:214631	170/549 (31%)
Mcm9	NP_082106.3	MCM_OB	116..243	CDD:465381	28/133 (21%)
		MCM9	305..603	CDD:350666	123/320 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	659..1101		1/3 (33%)
		PTZ00449	<739..>1004	CDD:185628