DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm8

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001277983.1	Gene:	Mcm8 / 66634	MGIID:	1913884	Length:	833	Species:	Mus musculus

Alignment Length:	802	Identity:	226/802 - (28%)
Similarity:	368/802 - (45%)	Gaps:	165/802 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMED-- 71
            ::||:.:..::             .:.|.|:.|  |.||.::.|...::        |||.:.
Mouse    73 LYFSEVYSNNS-------------PFIEKIQAF--EKFFTRHIDLYDKD--------EIERKGSI 114

  Fly    72 LVGFDE-TLADKLNKQPTEHLEIFEEAAREVADEITA---------PRPEHEEHMHDIQIL--LS 124
            ||.|.| |.||::    |..:...|.|.|:..::..|         ...:.|.|..::|..  ||
Mouse   115 LVDFKELTKADEI----TNLIPDIENALRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLS 175

  Fly   125 S----------------NANP-TNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCST 172
            :                |..| |:::.:::.|..|.:.|.|.:|..|.|....|.|:.||.:|..
Mouse   176 NGGETMVNVPHIYARVYNYEPLTHLKNIRATCYGKYISIRGTVVRVSNIKPLCTNMAFQCAACGE 240

  Fly   173 V----IPNLKVNPGLEGYALPRKCNTEQA-GRPKCPL--DPFFIMPDKCKCVDFQTLKLQELPDF 230
            :    :|:.|       |.||.||..... ||...||  .|..:      .:|:|.:|:|||...
Mouse   241 IQSFPLPDGK-------YTLPTKCPVPACRGRSFAPLRSSPLTV------TLDWQLIKIQELMSD 292

  Fly   231 VPQ--GEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVV 293
            ..:  |.|||.::......|.:..|||:.|.:.||..:.. .:...|:..:|.:..:   |:...
Mouse   293 AQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGIVKVSN-SEEGSRNKNDKCMFLL---YIEAN 353

  Fly   294 GITVDSEGAGAISRYSNITSDEEEH-------------FRRMAASGDIYERLSQSLAPSIFGSRD 345
            .:: :|:|..|     ....|..:|             .|.:.|..::.:.:..||.|.|||...
Mouse   354 SVS-NSKGPKA-----QTAEDGCKHGTLMEFSLKDLYAIREIQAEENLLKLVVNSLCPVIFGHEL 412

  Fly   346 IKKAITCMLFGGSRK------RLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGK 404
            :|..:|..|||||:|      |:|    .|||.:||::||||..|||:|:....|||..||..|.
Mouse   413 VKAGLTLALFGGSQKYADDKNRIP----IRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGN 473

  Fly   405 GSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 469
            .::::|||.::.||..:.:|.:|.||:||.|.|:..|||||||....: |:.||||||:||:|||
Mouse   474 TTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKA 537

  Fly   470 GITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHI 533
            |:..:|.:|.|::||||.:.|.::..:. .||:.....:|||||::||:.|..:|..|..|::|:
Mouse   538 GVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHV 602

  Fly   534 INVHLSSNKSAPS----------------------------EPAEGE----ISLSTFKKYIHYCR 566
            |.:.....|:..|                            :.|.||    |.....:|||.|.|
Mouse   603 IAIRAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKVAPGEQTDPIPHQLLRKYIGYAR 667

  Fly   567 THCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFA 631
            .:..||||..|.:.|:..|:.:|       |.|.:..|.|||.||||::||::|:.|::.|:..|
Mouse   668 QYVHPRLSTDAAQALQDFYLELR-------KQSQRVGSSPITTRQLESLIRLTEARARLELREEA 725

  Fly   632 TDEHVNEALRLFQVSTLDAAMTGSLAGAEG-FTTEEDQETLNRIEKQLKRRF--AIGSQVSEQNI 693
            |.|...:.:.:.:.|     |.|:.:...| ...|..|.......:...:||  |:.| ::|:..
Mouse   726 TREDAEDIIEIMKHS-----MLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFISALNS-IAERTY 784

  Fly   694 LQDFLRQKYEERTVMKVIHTMI 715
            ...|  |.::.|.:.|.::..:
Mouse   785 NNIF--QYHQLRQIAKELNIQV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	25/106 (24%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	182/581 (31%)
Mcm8	NP_001277983.1	MCM_N	91..216	CDD:291233	31/138 (22%)
		Mcm2	132..830	CDD:224162	206/716 (29%)
		AAA	428..586	CDD:99707	70/162 (43%)
		PEPcase	<676..>747	CDD:304407	25/82 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820