DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and mcm6

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001076318.1	Gene:	mcm6 / 566409	ZFINID:	ZDB-GENE-030909-6	Length:	830	Species:	Danio rerio

Alignment Length:	818	Identity:	251/818 - (30%)
Similarity:	380/818 - (46%)	Gaps:	139/818 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GDNQQDAQI----NLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDE 77
            |.||...|:    ..:..:|.::.|:..|...:...||....:......|..|.:...||.||::
Zfish     7 GVNQNAGQVIKDELAEKCQKLFQAFLEEFQNSDGEVKYLRDAEELIRPERNTLAVSFTDLEGFNQ 71

  Fly    78 TLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPT--NIRQLKSDCV 140
            .||..:.:   |...::....|.|.:...    ||.|.....:..::....||  .||:|.:..|
Zfish    72 ELATAIQE---EFYRLYPYLCRAVRNFAR----EHGEVPTSKEFYVAFQDLPTRHKIRELTTVKV 129

  Fly   141 SKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI-----------PNLKVNPGLEGYALPRKCNT 194
            ..||:|:|.:|....:..:....:..||.|..||           |::..||         .||.
Zfish   130 GSLVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQPSICRNP---------VCNN 185

  Fly   195 EQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNR-- 257
            .:.         |.:..:|.|.:|||.|::||....:|:|.|||.:::.......|....|::
Zfish   186 RRR---------FLLDTNKSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCD 241

  Fly   258 -----VLIQGIYSIRKVGKPSRRDGREKAV-------------VGVR-------------AP-YM 290
                 :::..|..:...|..:....|...|             :|||             || ..
Zfish   242 FIGSLIVVPDISQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNP 306

  Fly   291 RVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLF 355
            |..|..:..|...|.|....::..|.|....|:...::|..|..||.|:|.|:.::|:.|..|||
Zfish   307 RFGGKEIRDEEQTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLF 371

  Fly   356 GGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQ 420
            ||..|...:|...||||||.::|||.|||||.||.||:..|.|||||||.||||||||:|::|.:
Zfish   372 GGVPKTTMEGTSLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEE 436

  Fly   421 TRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAA 485
            :..||:|.||::|||.||.||||||||...|:||||||||||||||.|||:..|||:|.|:||||
Zfish   437 SHEFVIEAGALMLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAA 501

  Fly   486 NSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPA 549
            |.:.||:|.:|. ::|::....|:||||:.||:.|..:|..|..:|:.|:::|     |......
Zfish   502 NPVSGRYDRSKSLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLH-----SRIENSV 561

  Fly   550 EGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEA 614
            :...||...::|:.:.| ...|::|:.:.|.:..:|..:|...|.....|..|    |||||||:
Zfish   562 DRVYSLDEIRRYLLFAR-QFKPKISKESEEFIVEQYKRLRQRDGSGVTKSAWR----ITVRQLES 621

  Fly   615 VIRISESLAKIRLQPFATDEHVNEALRLFQVSTL---------------------DAAMTGSLA- 657
            :||:|||:|::........:||.||.||...|.:                     |..|.|...
Zfish   622 LIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEEAMEEEEDNQMNGHDVP 686

  Fly   658 -GAEGFTTEE--DQETLNRI----------EKQLKRRFAIGSQVSEQNILQDFLR--QKYEERTV 707
             |..|....|  ..|..|.|          :..|:..||...::|  |:|...||  ::.|:...
Zfish   687 NGVNGAVNGEVNGHEHTNGINGHGVNGETAKPSLRLSFAEYKRIS--NLLVLHLRRAEEDEDEAA 749

  Fly   708 MK---VIHTMIR--RGELQHRMQ--------RKMLYRI 732
            :|   |::..::  ..|:...|:        .|::||:
Zfish   750 LKKSEVVNWYLKEIESEIDSEMELISKKTMIEKVIYRL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	19/92 (21%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	203/567 (36%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	27/116 (23%)
		MCM	117..655	CDD:214631	202/565 (36%)
		P-loop_NTPase	<445..532	CDD:304359	53/86 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820