DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and mcm6l

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001020704.1	Gene:	mcm6l / 564982	ZFINID:	ZDB-GENE-050913-141	Length:	824	Species:	Danio rerio

Alignment Length:	731	Identity:	236/731 - (32%)
Similarity:	359/731 - (49%)	Gaps:	91/731 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GFDDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEI 67
            |.:.|||...|...           :..:|.:.||:..|.::|....|....:......|..|.:
Zfish     4 GVEAAGVHVRDELS-----------EKCQKLFLEFLEEFQDKNGDALYLSDAQELIRPERNTLTV 57

  Fly    68 EMEDLVGFDETLADKLNKQPTEHLEIFEEAAREV----ADEITAPRPEHEEHMHDIQILLSSNAN 128
            ...::..:::.||..:.:   |:..::....|.|    .|....| |..|     ..:..|...:
Zfish    58 SFSNIEHYNQQLATTIQE---EYYRVYPFLCRAVRHFARDHGNIP-PSKE-----FYVAFSEFPS 113

  Fly   129 PTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC- 192
            ...||:|.:..:..|::|:|.:|....:..:....:..||.|.:||.:::..   ..|..|..|
Zfish   114 RQKIRELSTVRIGTLLRISGQVVRTHPVHPELVSGTFLCLDCQSVIKDVEQQ---FKYTQPTICK 175

  Fly   193 NTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNR 257
            |...|.|.:..||     .:|.:.||||..::||....:|:|.|||.:::.......|....|:|
Zfish   176 NPVCANRRRFMLD-----TNKSRFVDFQKGRIQETQAELPRGSIPRSVEVILRAEAVETAQAGDR 235

  Fly   258 -------VLIQGIYSIRKVG----KPSRRDGRE----------KAVVGVR---------APYM-- 290
                   |::..:.::...|    ..||..|:|          || :|||         |.|:
Zfish   236 CDFTGTLVVVPDVSAMALAGTRAETSSRVTGKEGFETDGIQGLKA-LGVRELSYRLAFLANYVAP 299

  Fly   291 ---RVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITC 352
               |..|..:..|...|.|..:.:|..|.|....|:...::|..|..||.|:|.|:.:||:.|..
Zfish   300 TNPRFGGKELRQEDQTAESVKNQMTVLEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGILL 364

  Fly   353 MLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMK 417
            |||||..|...:|...||||||.::|||.|:|||.||.||..||.|||||||.||||||||:|:|
Zfish   365 MLFGGVAKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEDFAPRAVYTSGKASSAAGLTAAVVK 429

  Fly   418 DPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVL 482
            |.::..||:|.||::|||.||.||||||||...|:||||||||||||||.|||:..|||:|.|:|
Zfish   430 DEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSIL 494

  Fly   483 AAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPS 546
            ||||.|.||::..|. ::|::....|:||||:.||:.|..:|..|..:|:.|:::|..:     .
Zfish   495 AAANPIDGRYNRAKSLKQNVNMSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARN-----V 554

  Fly   547 EPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQ 611
            |..|...|....::||.:.| ...|:::..|.|.:..:|..:|    |::.....:.:..|||||
Zfish   555 ESVERVYSTDEIQRYILFAR-QFQPKITVEAQEFVVDQYKRLR----QRDGGGTTKSAWRITVRQ 614

  Fly   612 LEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEK 676
            ||:::|:||.:|::........:||.||.||...|.:.......     .|..|.|::.:|. :.
Zfish   615 LESMLRLSEGMARLYCSDEVQPKHVKEAFRLLNKSIIRVDSPDI-----NFDQEHDEDNIND-QN 673

  Fly   677 QLKRRFAIGSQVSEQN 692
            :|     .|.:...||
Zfish   674 EL-----FGKETEGQN 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	17/96 (18%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	205/556 (37%)
mcm6l	NP_001020704.1	MCM_N	23..133	CDD:291233	22/118 (19%)
		MCM	116..651	CDD:214631	205/553 (37%)
		P-loop_NTPase	<441..528	CDD:304359	53/86 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820