Protein Alignment Mcm5 and mcm6.2

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001016221.1
• Gene: mcm6.2 / 548975
• XenbaseID: XB-GENE-5870537
• Length: 821
• Species: Xenopus tropicalis
• Alignment Length: 816
• Identity: 252/816 - (30%)
• Similarity: 390/816 - (47%)
• Gaps: 139/816 - (17%)

  Fly     5 DDAGVFFSDNFGGDNQQDAQINLQAVKKKYKEFIRTFNEE-------NFFYKYRDTLKRNYLNGR 62
            |.||..|.|......|           |.:.||:    ||       |.:....:.|.|...|
 Frog    13 DTAGQLFKDELSDKCQ-----------KLFLEFL----EECKGKDGSNLYVSAAEELVRPERN-- 60

  Fly    63 YFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVAD------EITAPRPEHEEHMHDIQI 121
             .|.:...|:..:::.||..:.:   |:..::....|.|..      .|.|.:        :..:
 Frog    61 -TLVVNFTDIEYYNQQLATTIQE---EYYRVYPHLCRAVRSFARQMGNIPANK--------EFYV 113

  Fly   122 LLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGY 186
            ..|.......||:|.|..:..|::|:|.:|....:..:....:..|:.|.:|:.:::..   ..|
 Frog   114 AFSDFPARQKIRELSSAKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSVVKDVEQQ---FRY 175

  Fly   187 ALPRKC-NTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLF------- 243
            ..|..| |...|.|.:..||     .:|.:.||||.:::||....:|:|.|||.:::.
 Frog   176 TQPTICKNPVCANRRRFTLD-----TNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVE 235

  Fly   244 -------CDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDG-REKAVVGVRAPYMR--------- 291
                   ||.:....|||....|..|...:....|.:..:| ..:.|.|::|..:|
 Frog   236 TAMAGDRCDFTGTLIVVPDISALAAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFL 300

  Fly   292 --VVGIT--------VDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDI 346
              .||.|        :..|...|.|..:.:|..|.|....|:...::|..|..||.|:|.|:.:|
 Frog   301 ACHVGATNPRFGGKDLREEDQTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEI 365

  Fly   347 KKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGL 411
            |:.:..|||||..|...:|...||||||.::|||.|:|||.||.||:.:|.|||||||.||||||
 Frog   366 KRGVLLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGL 430

  Fly   412 TASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLN 476
            ||:|:||.::..||:|.||::|||.||.||||||||...|:||||||||||||||.|||:..|||
 Frog   431 TAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLN 495

  Fly   477 SRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSS 540
            :|.|:|||||.:.||::.:|. :.|::....|:||||:.||:.|..:|..|..:|:.|:::|..:
 Frog   496 ARTSILAAANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARN 560

  Fly   541 NKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSI 605
            .:|     .|...|:...::|:.:.| ...|::::.|.|.:..:|..:|    |::.:...:.|.
 Frog   561 EES-----IERVYSIEDIQRYLLFAR-QFQPKITKEAEEFIVEQYRRLR----QRDGSGVAKSSW 615

  Fly   606 PITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRL-----FQVSTLDAAM------------- 652
            .|||||||::||:|||:|::........:||.||.||     .:|.|.|.:.
 Frog   616 RITVRQLESLIRLSESMARMHCSDEVQPKHVKEAFRLLSKSIIRVDTPDVSFDQGEDEKNVEEEV 680

  Fly   653 -TGSL-AGAEGFTTEEDQETLN---RIEKQLKRRFAIGSQVSEQNILQDFLRQKYEE------RT 706
             ..:| .|.|...|.:| |.:|   .....||..||...|:|...:|.   .||.||      .|
 Frog   681 NNANLNNGEEAMETNQD-EPINDKPSTNAGLKMSFAEYKQISNLLVLH---MQKMEEVEEECHLT 741

  Fly   707 VMKVIHTMIRRGE----------LQHRMQRKMLYRI 732
            ...:::..::..|          |:.|:..|:::|:
 Frog   742 TTDLVNWYLKEMEAEIETETELILKKRLIEKVIHRL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	18/106 (17%)
		MCM	128..648	CDD:214631	201/560 (36%)
mcm6.2	NP_001016221.1	MCM_N	28..117	CDD:464206	19/117 (16%)
		MCM	123..658	CDD:475121	200/552 (36%)
		Arginine finger	529..532		2/2 (100%)
		MCM6_C	710..819	CDD:465688	17/71 (24%)