DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm9

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_038955210.1	Gene:	Mcm9 / 499437	RGDID:	1560557	Length:	1128	Species:	Rattus norvegicus

Alignment Length:	697	Identity:	199/697 - (28%)
Similarity:	337/697 - (48%)	Gaps:	70/697 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPT 88
            |:.|  |.:.::.::..:::.:...    .||....:..|.|.:....|...:..:.|.....|.
  Rat     5 QVTL--VGQVFESYVSEYHKNDILL----ILKERDEDAHYPLVVNAMTLFETNMEIGDYFTVFPN 63

  Fly    89 EHLEIFEEAAREVADEI--TAPRPEHEEHMHDIQILLSS-NANPTNIRQ--LKSDCVSKLVKIAG 148
            |.|.:|:.|.|..|..:  :.|.||......::...:|. ...|..:|:  .|:..|...:.:.|
  Rat    64 EVLTVFDSALRRSALAVLQSLPEPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTG 128

  Fly   149 IIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGY---ALPRKCNTEQAGRPKCPLDPFFIM 210
            .::..|.:..........|..|..|   ..|....|.|   :.|..|.:...    |....|..:
  Rat   129 TVIRTSLVKVLEFERDYMCNKCKYV---FTVKADFEQYYTFSRPSSCPSSDT----CDSSKFTCL 186

  Fly   211 PD----KCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGK 271
            .|    ..:|.|:|.:|:||....:..|.|||.:::..:..|.:....|:.:.|.|:  :.:..|
  Rat   187 SDLSASPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGV--VMQRWK 249

  Fly   272 PSRRDGREKAVVGVRAPYMRV-----VGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYER 331
            |.:||.|.:..:.::|.|::|     .|:.:|.:.....       .|..||::....:|  ...
  Rat   250 PFQRDMRCEVEIVLKANYVQVNNEQSSGMVMDEDARKEF-------EDFWEHYKSDPFAG--RNE 305

  Fly   332 LSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAP 396
            :..||.|.:||...:|.|:..:|.||.::....|...||:.::||:|||||.|||.||:..|:.|
  Rat   306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITP 370

  Fly   397 IAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQ 461
            .:|.|:|.||::||||.:.:||....|  :|.||:||||.|:.|||||:.::|.||.:|||||||
  Rat   371 RSVLTTGIGSTSAGLTVTAVKDSGEWN--LEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQ 433

  Fly   462 QTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESR 525
            ||||:||||:...||:|.::|||.|. .|::|..:. ..||.....:|||||:|.::.|..:|..
  Rat   434 QTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTRNEDW 497

  Fly   526 DITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRS 590
            |     .||:..:..||..||: :|...|:...|.|....| :..|.||:.:.:.|...|
  Rat   498 D-----RIISSFILENKGYPSK-SENLWSMEKMKTYFCLIR-NLHPTLSDVSNQVLLRYY----- 550

  Fly   591 GAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGS 655
               |.::.||.|.:...|:|.||::||::|:.|::..:...|   :.:|:.:  ||.::::|.|.
  Rat   551 ---QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSTVT---LEDAITV--VSVMESSMQGG 607

  Fly   656 --LAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQ 700
              |.|.....|...:....:..:|.:   .|..::..|::||:.||:
  Rat   608 ALLGGVNALHTSFPESPRAQYRRQCE---LILEKLELQSLLQEELRR 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	16/94 (17%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	167/534 (31%)
Mcm9	XP_038955210.1	MCM_OB	116..243	CDD:407328	28/133 (21%)
		MCM9	305..603	CDD:350666	122/320 (38%)
		PHA03307	667..>1014	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010