Protein Alignment Mcm5 and Mcm9

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_001403310.1
• Gene: Mcm9 / 499437
• RGDID: 1560557
• Length: 1128
• Species: Rattus norvegicus
• Alignment Length: 697
• Identity: 199/697 - (28%)
• Similarity: 337/697 - (48%)
• Gaps: 70/697 - (10%)

  Fly    24 QINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPT 88
            |:.|  |.:.::.::..:::.:...    .||....:..|.|.:....|...:..:.|.....|.
  Rat     5 QVTL--VGQVFESYVSEYHKNDILL----ILKERDEDAHYPLVVNAMTLFETNMEIGDYFTVFPN 63

  Fly    89 EHLEIFEEAAREVADEI--TAPRPEHEEHMHDIQILLSS-NANPTNIRQ--LKSDCVSKLVKIAG 148
            |.|.:|:.|.|..|..:  :.|.||......::...:|. ...|..:|:  .|:..|...:.:.|
  Rat    64 EVLTVFDSALRRSALAVLQSLPEPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTG 128

  Fly   149 IIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGY---ALPRKCNTEQAGRPKCPLDPFFIM 210
            .::..|.:..........|..|..|   ..|....|.|   :.|..|.:...    |....|..:
  Rat   129 TVIRTSLVKVLEFERDYMCNKCKYV---FTVKADFEQYYTFSRPSSCPSSDT----CDSSKFTCL 186

  Fly   211 PD----KCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGK 271
            .|    ..:|.|:|.:|:||....:..|.|||.:::..:..|.:....|:.:.|.|:  :.:..|
  Rat   187 SDLSASPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGV--VMQRWK 249

  Fly   272 PSRRDGREKAVVGVRAPYMRV-----VGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYER 331
            |.:||.|.:..:.::|.|::|     .|:.:|.:.....       .|..||::....:|  ...
  Rat   250 PFQRDMRCEVEIVLKANYVQVNNEQSSGMVMDEDARKEF-------EDFWEHYKSDPFAG--RNE 305

  Fly   332 LSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAP 396
            :..||.|.:||...:|.|:..:|.||.::....|...||:.::||:|||||.|||.||:..|:.|
  Rat   306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITP 370

  Fly   397 IAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQ 461
            .:|.|:|.||::||||.:.:||....|  :|.||:||||.|:.|||||:.::|.||.:|||||||
  Rat   371 RSVLTTGIGSTSAGLTVTAVKDSGEWN--LEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQ 433

  Fly   462 QTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESR 525
            ||||:||||:...||:|.::|||.|. .|::|..:. ..||.....:|||||:|.::.|..:|..
  Rat   434 QTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTRNEDW 497

  Fly   526 DITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRS 590
            |     .||:..:..||..||: :|...|:...|.|....| :..|.||:.:.:.|...|
  Rat   498 D-----RIISSFILENKGYPSK-SENLWSMEKMKTYFCLIR-NLHPTLSDVSNQVLLRYY----- 550

  Fly   591 GAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGS 655
               |.::.||.|.:...|:|.||::||::|:.|::..:...|   :.:|:.:  ||.::::|.|.
  Rat   551 ---QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSTVT---LEDAITV--VSVMESSMQGG 607

  Fly   656 --LAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQ 700
              |.|.....|...:....:..:|.:   .|..::..|::||:.||:
  Rat   608 ALLGGVNALHTSFPESPRAQYRRQCE---LILEKLELQSLLQEELRR 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	16/95 (17%)
		MCM	128..648	CDD:214631	167/534 (31%)
Mcm9	NP_001403310.1	MCM_OB	116..243	CDD:465381	28/133 (21%)
		MCM9	305..603	CDD:350666	122/320 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..737
		PHA03307	667..>1014	CDD:223039