DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and mcm2

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001006772.1	Gene:	mcm2 / 448458	XenbaseID:	XB-GENE-999974	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	242/757 - (31%)
Similarity:	381/757 - (50%)	Gaps:	119/757 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KYKEFIRTFNEEN----FFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEI 93
            ::|.|:||..:|:    |..|..|..|.|    :..|.:..|||...:..||..|.:.|.|.|:|
Frog   183 RFKNFLRTHVDEHGHNVFKEKISDMCKEN----KESLVVNYEDLAAREHVLAYFLPEAPAEMLKI 243

  Fly    94 FEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISA 158
            |:|||:||   :....|:::....:|.:.:|.......:|.|:...:::|::.:|::...:|:..
Frog   244 FDEAAKEV---VLVMYPKYDRIAREIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTCCTGVLP 305

  Fly   159 KATRMSIQCLSCSTVI------PNLKVNPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKC 216
            :.:.:...|..|:.::      .|.:|.||        .|       |:| .|.||.|..::...
Frog   306 QLSMVKYNCNKCNFILGPFFQSQNQEVKPG--------SC-------PECQSLGPFEINMEETVY 355

  Fly   217 VDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKA 281
            .::|.:.:||.|..|..|.:||.........|.:...||:.:.:.|.|.....|..:..:|....
Frog   356 QNYQRITIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGTYHNNYDGSLNTANGFPVF 420

  Fly   282 VVGVRAPYMR------VVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSI 340
            ...:.|.::.      .||...|.:....::    ::.||.           |.||:..|:||||
Frog   421 ATVILANHITKKDDKVAVGELTDEDVKAIVA----LSKDER-----------IGERIFASIAPSI 470

  Fly   341 FGSRDIKKAITCMLFGGSRKRLPDGLCR-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGK 404
            :|..|||:.:...||||..|. |.|..: ||||||||.|||||||||.||:|||||..||:|:|:
Frog   471 YGHEDIKRGLALALFGGEAKN-PGGKHKVRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQ 534

  Fly   405 GSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 469
            |:||.||||.|.:.|.|:.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||
Frog   535 GASAVGLTAYVQRHPVTKEWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKA 599

  Fly   470 GITTTLNSRCSVLAAANSIFGRWDDT-KGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHI 533
            ||.|:|.:||:::||:|.|.||:|.: ...||:|....|:||||::.:|:|..|..:|..||:.:
Frog   600 GIVTSLQARCTIIAASNPIGGRYDPSLTFSENVDLTEPIVSRFDILCVVRDTVDPVQDEMLARFV 664

  Fly   534 INVHLSSNKSAPSEPAEGE------------ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYV 586
            :..|:..:.|: .:.|.||            :.....||||.|.:....|:|::...:|:...|.
Frog   665 VGSHIKHHPSS-KDIANGEEFALPNTFGVEPLPQEVLKKYIMYSKEKIHPKLNQMDQDKVAKMYS 728

  Fly   587 LMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA- 650
            .:|       |.|....|||||||.:|::||::|:.|::.|:.:..::.||.|:|:...|.:|.
Frog   729 DLR-------KESMATGSIPITVRHIESMIRMAEAHARMHLRDYVVEDDVNMAIRVMLESFIDTQ 786

  Fly   651 ------AMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKY------- 702
                  :|..:.|....| ..::.|.|..:.|||         |:||...|   |.:|
Frog   787 KFSVMRSMRKTFARYLAF-RRDNNELLLFVLKQL---------VAEQTSYQ---RNRYGAQQDTI 838

  Fly   703 ---EERTVMKV----IHT--------MIRRGELQHRMQRKML 729
               |:..|.|.    ||.        :.:.....|.:::||:
Frog   839 EVPEKDLVDKARQINIHNLSAFYDSDLFKMNRFTHDVKKKMI 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	29/94 (31%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	189/546 (35%)
mcm2	NP_001006772.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		MCM2_N	44..167	CDD:372227
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..151
		MCM_N	184..272	CDD:379644	29/94 (31%)
		MCM	276..783	CDD:214631	189/545 (35%)
		Arginine finger	640..643		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920