DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and MCM6

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_005906.2	Gene:	MCM6 / 4175	HGNCID:	6949	Length:	821	Species:	Homo sapiens

Alignment Length:	805	Identity:	243/805 - (30%)
Similarity:	378/805 - (46%)	Gaps:	141/805 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GDNQQDAQINLQAVKKKYK---EFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDET 78
            |...|..::..:..:|..|   :|:..|...:...||....:......|..|.:...||..|::.
Human    10 GAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQ 74

  Fly    79 LADKLNKQPTEHLEIFEEAARE----VADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDC 139
            |:..:.:   |...::....|.    |.|....|..:      |..:..........||:|.|..
Human    75 LSTTIQE---EFYRVYPYLCRALKTFVKDRKEIPLAK------DFYVAFQDLPTRHKIRELTSSR 130

  Fly   140 VSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC-NTEQAGRPKCP 203
            :..|.:|:|.:|....:..:....:..||.|.|||.:::..   ..|..|..| |...|.|.:
Human   131 IGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQ---FKYTQPNICRNPVCANRRR-- 190

  Fly   204 LDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQG----IY 264
               |.:..:|.:.||||.:::||....:|:|.|||.|::.......|....|::....|    :.
Human   191 ---FLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVP 252

  Fly   265 SIRKVGKPSRR----------DGREK------AVVGVRAPYMRVV--------------GITVDS 299
            .:.|:..|..|          ||.|.      ..:|||....|:|              |..:..
Human   253 DVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRD 317

  Fly   300 EGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPD 364
            |...|.|..:.:|..|.|....|:...::|..|..||.|:|.|:.::|:.:..|||||..|...:
Human   318 EEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGE 382

  Fly   365 GLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGG 429
            |...||||||.::|||.|||||.||.||:.:|.|||||||.||||||||:|::|.::..||:|.|
Human   383 GTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAG 447

  Fly   430 AMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDD 494
            |::|||.||.||||||||...|:||||||||||||||.|||:..|||:|.|:|||||.|.|.:|.
Human   448 ALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDR 512

  Fly   495 TKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTF 558
            :|. ::||:....|:||||:.||:.|..:|..|..:|:.|:::|     |...|..:...||...
Human   513 SKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH-----SRIEESIDRVYSLDDI 572

  Fly   559 KKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLA 623
            ::|:.:.| ...|::|:.:.:.:..:|..:|    |::.:...:.|..|||||||::||:||::|
Human   573 RRYLLFAR-QFKPKISKESEDFIVEQYKHLR----QRDGSGVTKSSWRITVRQLESMIRLSEAMA 632

  Fly   624 KIRLQPFATDEHVNEALRL-----FQVSTLD-----------------------AAMTGSLAGAE 660
            ::........:||.||.||     .:|.|.|                       |.....:.|..
Human   633 RMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGIN 697

  Fly   661 GFTTEEDQET-----------------------LNRIEKQ-----LKRRFAIG-------SQV-S 689
            |:..:.:||:                       |.::|::     |||...:.       |:: |
Human   698 GYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDS 762

  Fly   690 EQNILQDFLRQKYEERTVMKVIHTM 714
            |:.::.       ::|.:.||||.:
Human   763 EEELIN-------KKRIIEKVIHRL 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	18/99 (18%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	203/560 (36%)
MCM6	NP_005906.2	MCM_N	27..114	CDD:405270	17/95 (18%)
		MCM	119..657	CDD:214631	202/555 (36%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:408078	13/75 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820