DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and MCM5

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_006730.2	Gene:	MCM5 / 4174	HGNCID:	6948	Length:	734	Species:	Homo sapiens

Alignment Length:	737	Identity:	506/737 - (68%)
Similarity:	617/737 - (83%)	Gaps:	9/737 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGFDDAGVFFSDNFGGDNQQD-AQINLQAVKKKYKEFIRTF----NEENFFYKYRDTLKRNYLN 60
            |.||||.|:|:||:||||.|.| .|.....:::::|||:|.:    :...|.:||||.|||:|..
Human     1 MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNL 65

  Fly    61 GRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSS 125
            |.|::|:|||||..|||.|||.|.|||.|||::.||||:|||||:|.|||..||.:.|||::|.|
Human    66 GEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKS 130

  Fly   126 NANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPR 190
            :|:|::||.||||.:|.||||.|||:|||.:.|||||:||||.||...:.|:.:.||||||||||
Human   131 DASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPR 195

  Fly   191 KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPG 255
            ||||:|||||||||||:||||||||||||||||||||||.||.||:|||:||:|||.||::||||
Human   196 KCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPG 260

  Fly   256 NRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFR 320
            |||.|.|||||:|.|..:.| ||::..||:|:.|:||:||.||::|:|. |....::..|||.||
Human   261 NRVTIMGIYSIKKFGLTTSR-GRDRVGVGIRSSYIRVLGIQVDTDGSGR-SFAGAVSPQEEEEFR 323

  Fly   321 RMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKS 385
            |:||..::||.:|:|:||||||..|:||||.|:|||||||||||||.||||||:|:|||||||||
Human   324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKS 388

  Fly   386 QLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRED 450
            ||||||||.:||.||||||||||||||||||:||.:|||:|||||||||||||||||||||||||
Human   389 QLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRED 453

  Fly   451 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMIF 515
            |||||||||||||||||||||||||||||||||||||:|||||:||||:||||||||||||||||
Human   454 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIF 518

  Fly   516 IVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEK 580
            ||||.|:|.||:.||||:|.:|:|:  ...::..||||.|:..||:|.|||..||||||..|.||
Human   519 IVKDEHNEERDVMLAKHVITLHVSA--LTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEK 581

  Fly   581 LKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQV 645
            ||:||::|||||.|.|:.||:|.|||||||||||::||:|:|:|::||||||:..|.||||||||
Human   582 LKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQV 646

  Fly   646 STLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKV 710
            ||||||::|:|:|.||||::||||.|:||||||||||||||||||.:|::||.:|||.|..:.||
Human   647 STLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKV 711

  Fly   711 IHTMIRRGELQHRMQRKMLYRI 732
            :..|:||||:|||||||:|||:
Human   712 LQLMLRRGEIQHRMQRKVLYRL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	52/96 (54%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	376/519 (72%)
MCM5	NP_006730.2	MCM_N	32..129	CDD:405270	52/96 (54%)
MCM5	NP_006730.2	MCM	133..649	CDD:214631	376/519 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159413
Domainoid	1	1.000	382	1.000	Domainoid score	I839
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4904
Inparanoid	1	1.050	1028	1.000	Inparanoid score	I274
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53983
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0004690
OrthoInspector	1	1.000	-	-		oto88630
orthoMCL	1	0.900	-	-		OOG6_102165
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R695
SonicParanoid	1	1.000	-	-		X3292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800