Protein Alignment Mcm5 and MCM2

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_004517.2
• Gene: MCM2 / 4171
• HGNCID: 6944
• Length: 904
• Species: Homo sapiens
• Alignment Length: 798
• Identity: 250/798 - (31%)
• Similarity: 400/798 - (50%)
• Gaps: 143/798 - (17%)

  Fly    18 DNQQDAQI-----NLQAVK------------------KKYKEFIRTFNEEN----FFYKYRDTLK 55
            |.::|.::     ||:.:|                  .::|.|:||..:.:    |..:..|..|
Human   160 DGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCK 224

  Fly    56 RNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQ 120
            .|    |..|.:..|||...:..||..|.:.|.|.|:||:|||.||   :.|..|:::...:.|.
Human   225 EN----RESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEV---VLAMYPKYDRITNHIH 282

  Fly   121 ILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI------PNLKV 179
            :.:|.......:|.|:...:::|::.:|::.:.:|:..:.:.:...|..|:.|:      .|.:|
Human   283 VRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEV 347

  Fly   180 NPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLF 243
            .||        .|       |:| ...||.:..::....::|.:::||.|..|..|.:||.....
Human   348 KPG--------SC-------PECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAI 397

  Fly   244 CDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMR------VVGITVDSEGA 302
            ....|.:...||:.:.:.|||.....|..:..:|.......:.|.::.      .||...|.:
Human   398 LLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDED-- 460

  Fly   303 GAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLC 367
              :...::::.|::           |.|::..|:||||:|..|||:.:...||||..|. |.|..
Human   461 --VKMITSLSKDQQ-----------IGEKIFASIAPSIYGHEDIKRGLALALFGGEPKN-PGGKH 511

  Fly   368 R-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431
            : ||||||||.|||||||||.||::|||:..|::|:|:|:||.||||.|.:.|.:|.:.:|.||:
Human   512 KVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGAL 576

  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDT- 495
            ||||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:||:|:||||.|.||:|.:
Human   577 VLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSL 641

  Fly   496 KGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHL---SSNK-------SAPSEPAE 550
            ...||:|....|:||||::.:|:|..|..:|..||:.::..|:   .|||       .:.:|||.
Human   642 TFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAM 706

  Fly   551 GE------ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITV 609
            ..      :.....||||.|.:....|:|::...:|:...|..:|       |.|....||||||
Human   707 PNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLR-------KESMATGSIPITV 764

  Fly   610 RQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA-------AMTGSLAGAEGFTTEED 667
            |.:|::||::|:.|:|.|:.:..::.||.|:|:...|.:|.       :|..:.|....| ..::
Human   765 RHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSF-RRDN 828

  Fly   668 QETLNRIEKQL--------KRRFAIGSQ-----VSEQNILQDFLRQKYEERTVMKVIHT------ 713
            .|.|..|.|||        :.||  |:|     |.|:::: |..||..        ||.
Human   829 NELLLFILKQLVAEQVTYQRNRF--GAQQDTIEVPEKDLV-DKARQIN--------IHNLSAFYD 882

  Fly   714 --MIRRGELQHRMQRKML 729
              :.|..:..|.::|||:
Human   883 SELFRMNKFSHDLKRKMI 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	30/115 (26%)
		MCM	128..648	CDD:214631	189/550 (34%)
MCM2	NP_004517.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80
		Interaction with KAT7. /evidence=ECO:0000250	2..257		23/100 (23%)
		Interaction with DNJC9. /evidence=ECO:0000269|PubMed:33857403	61..130
		MCM2_N	73..182	CDD:403724	5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..167		2/6 (33%)
		MCM_N	197..287	CDD:464206	29/96 (30%)
		MCM	291..803	CDD:214631	189/549 (34%)
		Arginine finger	655..658		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	686..705		4/18 (22%)