Protein Alignment Mcm5 and Mcm7

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 762
• Identity: 242/762 - (31%)
• Similarity: 375/762 - (49%)
• Gaps: 147/762 - (19%)

  Fly    35 KEFIRTFNEENFFYKYRDTLKRNYLNG----------RYFLEIEMEDLVGFDETLADKLNKQPTE 89
            :|.|:||..|  |.|..|..|:.::.|          :..:.|:::||..|:|:||:.:......
  Fly    10 RESIKTFLSE--FCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNESLAEAVVDNCRR 72

  Fly    90 HLEIFEEAAREVADEITAPRPEHEEHMHDI-------QILLSS------------NANPT----- 130
            :..||.    :|..|:.....:.|.|..|.       ::::.|            |:.|:
  Fly    73 YTSIFS----DVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSFPSELMKR 133

  Fly   131 --------------NIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCST----VIPNL 177
                          :||::|:..:.|||.:.||:...:.:.......:..|..|.:    .:.:|
  Fly   134 FEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSL 198

  Fly   178 KVNPGLEGYALPR-KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQ 241
            ...|   .:..|. .|...:||      ...::.....|.|.||.:|:||..|.||.|.|||.:.
  Fly   199 SFTP---VHDCPSDDCRVNKAG------GRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMT 254

  Fly   242 LFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYM----RVVGITVDSEGA 302
            :.|...:.....||:.:::.|::      .|..|.|..:.:.|:.:...    |::.|..:.|
  Fly   255 IMCRGEVTRMAQPGDHIVVSGVF------LPLMRTGFAQMIQGLLSETFLQAHRIICINKNDE-- 311

  Fly   303 GAIS-RYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGL 366
              || :.:.:|.:|.|..    |..|.||||:.||||.|:|..|:|||:..:|.||..|| |||:
  Fly   312 --ISDKDAELTPEELEEL----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR-PDGM 369

  Fly   367 CRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAM 431
            ..||:||:.|:||||.||||||.::.::|..:.||:|:|||..||||:|||||.|....:||||:
  Fly   370 KIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTLEGGAL 434

  Fly   432 VLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK 496
            ||||.||.||||||||.:.||.||||.|||||||||||||.||||:|.|:|||||..|||::..:
  Fly   435 VLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGRYNPRR 499

  Fly   497 G-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKK 560
            . |:||.....:|||||::::::|..|...|:.|||||..|| |.:|..|:...  .:.::..::
  Fly   500 TVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVH-SHSKQPPTRVK--ALDMNLMRR 561

  Fly   561 YIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKI 625
            ||:.|:.. .|.:.:...:.:...||.:|     :|..:.|.::. .:.|.|..::|:|.:||::
  Fly   562 YINLCKRK-NPTIPDELTDYIVGAYVELR-----REARNQKDMTF-TSARNLLGILRLSTALARL 619

  Fly   626 RLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLK--------RRF 682
            ||......:.|.|||||.::|                     :::||:|.:..|        |.|
  Fly   620 RLSDSVEKDDVAEALRLLEMS---------------------KDSLNQIHEHQKGHVPNTSDRIF 663

  Fly   683 AI-------GSQVSEQNILQ------------DFLRQKYEERTVMKV 710
            ||       |..|...:|:.            |.....|||..|.:|
  Fly   664 AIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCIDDYEELNVWQV 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	24/106 (23%)
		MCM	128..648	CDD:214631	199/549 (36%)
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	24/98 (24%)
		MCM	145..641	CDD:475121	198/550 (36%)