DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and Mcm3

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001178734.2	Gene:	Mcm3 / 316273	RGDID:	1305168	Length:	813	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	229/773 - (29%)
Similarity:	351/773 - (45%)	Gaps:	146/773 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 INLQAVKKKYKEFIRTFNEENFFY-KYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPT 88
            :.|:..::.|.:|:....::..:. |.|:.:..|    :|.|.:.:.||...:|..|::|.....
  Rat    10 VELREAQRDYLDFLDDEEDQGIYQNKVRELISDN----QYRLIVNVNDLRRKNEKRANRLLNNAF 70

  Fly    89 EHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAA 153
            |.|..|:.|.::....|.|...:..|..: |.:..|..:...:.|.|.|..:|.:|.:.||:...
  Rat    71 EELVAFQRALKDFVASIDATYAKQYEEFY-IGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKC 134

  Fly   154 SGISAKATRMSIQC-------------LSCSTVIPNLKVNP-------------GLEGYALPRKC 192
            |.:..|..|....|             |:.....|:..|.|             ||..|.
  Rat   135 SLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYK----- 194

  Fly   193 NTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNR 257
                                     |.||:.:||:|:..|.|::||.:.:..|..|.::|.||:|
  Rat   195 -------------------------DHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKVKPGDR 234

  Fly   258 VLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRM 322
            :.:.|.|..    .|.::.|..............|..::.|.:.|        .::|:....::.
  Rat   235 IQVVGTYRC----LPGKKGGYTSGTFRTVLIACNVKQMSKDIQPA--------FSADDIAKIKKF 287

  Fly   323 A--ASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKS 385
            :  .|.|::|:|::||||||.|...:||||.|:|.||..:.|.:|...|||||:||:|||..|||
  Rat   288 SKTRSKDVFEQLARSLAPSIHGHDYVKKAILCLLLGGVERELENGSHIRGDINILLIGDPSVAKS 352

  Fly   386 QLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRED 450
            |||::|...||.|:.|:|:|||..||||:|..|.:|....:|.|||||||.|||||||||||.:.
  Rat   353 QLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDM 417

  Fly   451 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGE-ENIDFMPTILSRFDMI 514
            ||.||||.|||..::||||||...||:|||||||||.::||:|..|.. |||....::|||||::
  Rat   418 DRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLL 482

  Fly   515 FIVKDIHDESRDITLAKHIINVH--------------LSSNKS--APSEP--------------- 548
            ||:.|..|..:|..::.|::.:|              |.|:..  |..:|
  Rat   483 FIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPLGSSVDILATDDPDFTQDDQQDTRIYEK 547

  Fly   549 -----------AEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKR 602
                       .|..:|.:..|||||..:. ..|.|::.:...:...|..:||   |...:||..
  Rat   548 HDNLLHGSKKKREKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRS---QDSMSSDTA 608

  Fly   603 LSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAM------------TGS 655
            .:.|:|.|.||.:||::.:.||.|:......:...||:.|.|.:.....:            ...
  Rat   609 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKPSEDESD 673

  Fly   656 LAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKVIHT 713
            |...|..:.|||.|       |.::|....::..|.....||...:.|    |..:||
  Rat   674 LEDEEEKSQEEDTE-------QTRKRRKTQAKDGESYDPYDFSEAERE----MPQVHT 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	20/93 (22%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	192/590 (33%)
Mcm3	NP_001178734.2	MCM_N	17..129	CDD:291233	26/116 (22%)
		MCM	109..654	CDD:214631	192/590 (33%)
		P-loop_NTPase	340..479	CDD:304359	82/138 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820