Protein Alignment Mcm5 and Mcm6

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 223/678 - (32%)
• Similarity: 344/678 - (50%)
• Gaps: 84/678 - (12%)

  Fly    22 DAQINLQAVK--------KKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDET 78
            |||:....||        |.:::|:..|.|:... ||...........|..||:..||:..:|:.
  Fly     5 DAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEI-KYTRPAASLESPDRCTLEVSFEDVEKYDQN 68

  Fly    79 LADKLNKQPTEHLEIF----EEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDC 139
            ||..:.:   |:..|:    :..:..|.|.|..      :...|..:..:.......:|.|.:..
  Fly    69 LATAIIE---EYYHIYPFLCQSVSNYVKDRIGL------KTQKDCYVAFTEVPTRHKVRDLTTSK 124

  Fly   140 VSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLK-----VNPGLEGYALPRKCNTEQAGR 199
            :..|::|:|.:|....:..:.......||.|.|.|.|::     .||.:        |.     .
  Fly   125 IGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTNPTI--------CR-----N 176

  Fly   200 PKCPLDPFFIMP-DKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNR------ 257
            |.|.....|::. :|...:|||.:::||....:|:|.|||.:::.....|.|.|..|:|
  Fly   177 PVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGT 241

  Fly   258 -VLIQGIYSIRKVGKPSRRDGREK------AVVGVRAPYMR-------VVGITVDSEGA---GAI 305
             :::..:..:..||..:....|.|      .|.|::|..||       .:..:|.:..|   |..
  Fly   242 LIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTD 306

  Fly   306 SRYSNIT--------SDEEEH-FRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKR 361
            ...|.:|        :|.|.| ...|:...::|:.|..||.|||:|:.::|:.|....|||..|.
  Fly   307 LPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKT 371

  Fly   362 LPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVM 426
            ..:....||||||.::|||.|||||.||.|...:|.|:|||||.||||||||:|::|.::.:||:
  Fly   372 TTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVI 436

  Fly   427 EGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGR 491
            |.||::|||.|:.||||||||.:.|:|||||||||||||||:||:..|||:|.|:|||||.|.||
  Fly   437 EAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGR 501

  Fly   492 WDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISL 555
            :|.:|. ::||.....|:||||:.||:.|..:|..|..:|:.|:::|.:..:|........|:
  Fly   502 YDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEV-- 564

  Fly   556 STFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISE 620
               .:|:.:.| ...|.:|:.||..|...|..:|    |::..:..|.:..|||||||::||:||
  Fly   565 ---LRYVTFAR-QFKPVISQEAGHMLVENYGHLR----QRDTGTSGRSTWRITVRQLESMIRLSE 621

  Fly   621 SLAKIRLQPFATDEHVNEALRLFQVSTL 648
            ::||:.......:.||.||.||...|.:
  Fly   622 AMAKLECSNRVLERHVKEAFRLLNKSII 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	21/105 (20%)
		MCM	128..648	CDD:214631	198/558 (35%)
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	20/96 (21%)
		MCM	113..649	CDD:475121	198/558 (35%)
		MCM6_C	702..816	CDD:465688