Protein Alignment Mcm5 and Mcm3

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 811
• Identity: 247/811 - (30%)
• Similarity: 375/811 - (46%)
• Gaps: 158/811 - (19%)

  Fly    27 LQAVKKKYKEFIRTFNEENFFYKY-RDTL----KRNYLNGRYFLEIEMEDLVGFDETLADKLNKQ 86
            ::.::::|.:|:....::..:..: :|.:    ||..:|                  :.|...|.
  Fly     9 IKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVN------------------VNDLKRKN 55

  Fly    87 PTEHLEIFEEAA-------REVADEITAPRPEHEEHMHDIQILLS---SNANPTNIRQLKSDCVS 141
            |...|.:...||       |.:.:..:...|.:.:...|:.:...   .|.:.|. |.|.|..:.
  Fly    56 PQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTP-RSLTSIYLG 119

  Fly   142 KLVKIAGIIVAASGISAKATRMSIQCLSCSTV-------IPNLKVNPGLEGYALPRKCNTEQAGR 199
            .:|.:.||:...|.|..|..|....|.:...|       :.:.:..|  .|.|.|.|........
  Fly   120 NMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP--SGAAYPTKDEDGNLLE 182

  Fly   200 PKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIY 264
            .:..|..:         .|.|||.:||:|:..|.|::||.:.:.||..|.:|..||:||.|.|.|
  Fly   183 TEYGLSVY---------KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSY 238

  Fly   265 SIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHF--RRMAASGD 327
            ..    .|.:|.|.....       .|.|.:   :.....:|:.||:....|:..  :::|.:.|
  Fly   239 RC----LPGKRGGYTSGT-------FRTVLL---ANNISLLSKESNLDISREDIMLCKKLAKNND 289

  Fly   328 IYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVE 392
            |:|.||:||||||.|...:|:||.|:|.||..|.||:|...||||||||:|||..||||||::|.
  Fly   290 IFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVL 354

  Fly   393 KVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHE 457
            ..||.|:.|:|:|||..||||:|..|.:|....:|.|||||||.|||||||||||.:.||.||||
  Fly   355 NTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHE 419

  Fly   458 AMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGE-ENIDFMPTILSRFDMIFIVKDIH 521
            .|||..::|:||||..:||:|||||||||.::||:|..|.. |||....::|||||::|::.|:.
  Fly   420 VMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVI 484

  Fly   522 DESRDITLAKHIINVHLSSN-KSAPSEPA------------------------------------ 549
            |...|..::.|::.:|...| |.|..||.
  Fly   485 DSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKS 549

  Fly   550 ----EGEISLSTFKKYIHYCRTHC-GPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITV 609
                |..:|:...:||||..:  | .|:|.|.|.|.:.:.|..:||   |:...:|...:.|||.
  Fly   550 RQRHEKILSVEFMRKYIHIAK--CMKPKLGEQACEAIANEYSRLRS---QEAVETDVARTQPITA 609

  Fly   610 RQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVS----TLDAAMTGSLAGAEGFTTEED--- 667
            |.||.:||:|.:.|:.|:....|.:..:.|:.|.|.:    .||...........|...|:|
  Fly   610 RTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGE 674

  Fly   668 ---QETLNRIEKQLKRRFAIGSQVSEQNI------LQDFLRQK------------------YEER 705
               |.:.:|..|: .|...:|:...|::|      ..|..|::                  .||:
  Fly   675 ASSQRSPSRRSKR-TRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQ 738

  Fly   706 TVM-----KVIHTMIRRGELQHRMQRKMLYR 731
            :|.     ..|.:..|.||.::.:||  |:|
  Fly   739 SVATSTTEPAIISDARLGEFKNNLQR--LFR 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	15/108 (14%)
		MCM	128..648	CDD:214631	206/575 (36%)
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	15/105 (14%)
		MCM	106..648	CDD:214631	206/572 (36%)