DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm4

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_387500.1	Gene:	Mcm4 / 29728	RGDID:	3060	Length:	862	Species:	Rattus norvegicus

Alignment Length:	715	Identity:	235/715 - (32%)
Similarity:	345/715 - (48%)	Gaps:	128/715 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 INLQAVKKKYKEFIRTF------NEENFFYK-----YRDTLKRNYLNGRYFLEIEMEDLVGFDET 78
            :|:...|:.::.|::.|      .|||....     |...|....:.|..||.:..|.:..|.:.
  Rat   156 VNVATCKEHFQRFLQCFTDPLAKEEENVGIDITQPLYMQRLGEINITGEPFLNVNCEHIKSFGKN 220

  Fly    79 LADKLNKQPTEHLEIFEEAAREV-----ADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSD 138
            |..:|...|.|.:..|:.|..|:     .|.|..         |.||:...:.....::|.|..:
  Rat   221 LYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILE---------HQIQVRPFNALKTKSMRNLNPE 276

  Fly   139 CVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKCNTEQA----GR 199
            .:.:|:.|:|:::..|.:..:......||..|:                     :|.:.    ||
  Rat   277 DIDQLITISGMVIRTSQLIPEMQEAFFQCQVCA---------------------HTTRVEMDRGR 320

  Fly   200 PKCPLDPFFIMPDKCKCV------------------DFQTLKLQELPDFVPQGEIPRHLQLFCDR 246
                      :.:.|.||                  |.|.:||||.|:.:|.|:.|..:.||...
  Rat   321 ----------IAEPCTCVHCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLFAHN 375

  Fly   247 SLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVV-----------GITVDSE 300
            .|.::|.||:||.:.|||  |.|  |.|.:.|...|..|...::.|:           |:..::|
  Rat   376 DLVDKVQPGDRVNVTGIY--RAV--PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAE 436

  Fly   301 GAGAISRYSNITSDEE-EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLP- 363
                    ..:.|::. :..:.::...||||||:.:|||||:...||||.|...||||:||...
  Rat   437 --------QKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSH 493

  Fly   364 DGLCR-RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVME 427
            .|..: |.:||:||.|||||:|||||::|..:.|...|||||||||.||||.|||||:||..|::
  Rat   494 TGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQ 558

  Fly   428 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRW 492
            .||:||:|.|:.||||||||.|..|..:||.|||||:|||||||...||:|.|||||||.|..:|
  Rat   559 TGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQW 623

  Fly   493 DDTKGE-ENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLS 556
            :..|.. |||....|:|||||:||::.|..||:.|..||.|:::::..|.:....|    .:.::
  Rat   624 NPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEQE----FLDMA 684

  Fly   557 TFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISES 621
            ..|.||.|..:...|||||.|.:.|...||.||       |....|..:....||||::||::|:
  Rat   685 VLKDYIAYAHSTIMPRLSEEASQALIEAYVNMR-------KIGSSRGMVSAYPRQLESLIRLAEA 742

  Fly   622 LAKIRLQPFATDEHVNEALRLFQVSTLDAA------------MTGSLAGAEGFTTEEDQETLNRI 674
            .||:|.........|.||.||.:.:...:|            :|..::.......||..|.|.::
  Rat   743 HAKVRFSDKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKL 807

Fly 675 674
Rat 808 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	25/108 (23%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	203/556 (37%)
Mcm4	NP_387500.1	MCM_N	165..286	CDD:291233	28/129 (22%)
		MCM	266..769	CDD:214631	203/556 (37%)
		P-loop_NTPase	504..643	CDD:304359	85/138 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820