DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm8

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001099984.1	Gene:	Mcm8 / 296178	RGDID:	1305218	Length:	830	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	220/772 - (28%)
Similarity:	351/772 - (45%)	Gaps:	156/772 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMED--LVGFDETLADKLNKQPTEHLEIFEEAA 98
            |.|:.|  |.||.::.|...::        |||.:.  ||.|.|...|   .:.|..:...|.|.
  Rat    84 EKIQAF--EKFFTRHIDLYDKD--------EIERKGSILVDFKELTKD---NEITNLIPDIENAL 135

  Fly    99 REVADEITA---------PRPEHEEHMHDIQI---LLSS---------------NANP-TNIRQL 135
            |:..::..|         ...:.|.|..::|.   |.:.               |..| |:::.:
  Rat   136 RDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLCNGGGTMVNVPHIYARVYNYEPLTHLKNI 200

  Fly   136 KSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTV----IPNLKVNPGLEGYALPRKCNTEQ 196
            ::.|..|.:.|.|.:|..|.|....|:|:.||.:|..:    :|:.|       |.||.||....
  Rat   201 RATCYGKYISIRGTVVRVSNIKPLCTKMAFQCAACGEIQSFPLPDGK-------YNLPTKCPVPA 258

  Fly   197 A-GRPKCPL--DPFFIMPDKCKCVDFQTLKLQELPDFVPQ--GEIPRHLQLFCDRSLCERVVPGN 256
            . ||...||  .|..:      .:|:|.:|:|||.....:  |.|||.::......|.:..|||:
  Rat   259 CRGRSFTPLRSSPLTV------TMDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGD 317

  Fly   257 RVLIQGIYSI--RKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEH- 318
            .|.:.||..:  .:.|..|:.|         :..::..:.....|...|   :.:....|..:|
  Rat   318 TVTVTGIVKVSNSEEGSRSKND---------KCMFLLYIEANSVSNSKG---QKAQTAEDGCKHG 370

  Fly   319 ------------FRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRK------RLPDG 365
                        .:.:.|..::.:.:..||.|.|||...:|..:...|||||:|      |:|
  Rat   371 TLMEFSLKDLYAIQEIQAEENLLKLIVNSLCPVIFGHELVKAGLMLALFGGSQKYADDKNRIP-- 433

  Fly   366 LCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGA 430
              .|||.:||::||||..|||:|:....|||..||..|..::::|||.::.||..:.:|.:|.||
  Rat   434 --IRGDPHVLIVGDPGLGKSQMLQAACNVAPRGVYVCGNTATSSGLTVTLSKDSSSGDFALEAGA 496

  Fly   431 MVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDT 495
            :||.|.|:..|||||||....: |:.||||||:||:||||:..:|.:|.|::||||.:.|.::..
  Rat   497 LVLGDQGICGIDEFDKMGNQHQ-ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKA 560

  Fly   496 KG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPS------------- 546
            :. .||:.....:|||||::||:.|..:|..|..|::|:|.:.....::..|
  Rat   561 RTVSENLKMGSALLSRFDLVFILLDTPNEQHDHLLSEHVIAIRAGKQRAVSSATVSRVLSQDSNT 625

  Fly   547 ---------------EPAEGE----ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGA 592
                           :.|.||    |.....:|||.|.|.:..||||..|.:.|:..|:.:|
  Rat   626 SVLEVVSEKPLSERLKVAPGEKTDPIPHQLLRKYIGYARQYVHPRLSTEAAQALQDFYLELR--- 687

  Fly   593 GQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLA 657
                |.|.:..|.|||.||||::||::|:.|::.|:..||.|...:.:.:.:.|     |.|:.:
  Rat   688 ----KQSQRVGSSPITTRQLESLIRLTEARARLELREEATKEDAEDIIEIMKHS-----MLGTYS 743

  Fly   658 GAEG-FTTEEDQETLNRIEKQLKRRF--AIGSQVSEQ---NILQ-DFLRQKYEERTV 707
            ...| ...|..|.......:...:||  |:.| ::|:   ||.| ..|||..:|..:
  Rat   744 DEFGNLDFERSQHGSGMSNRSTAKRFISALNS-IAERTYNNIFQFHQLRQIAKELNI 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	24/101 (24%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	178/583 (31%)
Mcm8	NP_001099984.1	MCM_N	88..213	CDD:291233	28/137 (20%)
		Mcm2	129..827	CDD:224162	204/714 (29%)
		AAA	425..583	CDD:99707	70/162 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820