DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm5 and Mcm5

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_038953490.1	Gene:	Mcm5 / 291885	RGDID:	1306616	Length:	734	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	503/738 - (68%)
Similarity:	617/738 - (83%)	Gaps:	11/738 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGFDDAGVFFSDNFGGD-NQQDAQINLQAVKKKYKEFIRTF----NEENFFYKYRDTLKRNYLN 60
            |.||||.|:|:||:|||| ..::.|.....::|::|||:|.:    :...|.:||||.|||:|..
  Rat     1 MSGFDDPGIFYSDSFGGDPGAEEGQARKSHLQKRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNL 65

  Fly    61 GRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSS 125
            |.|::|:|||||..|||.|||.|.|||.|||::.||||:|||||:|.|||..:|.:.|||::|.|
  Rat    66 GEYWIEVEMEDLASFDEELADYLYKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKS 130

  Fly   126 NANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPR 190
            :|:|::||.||||.:|.||||.|||::||.:.|||||:||||.||...:.|:.:.||||||||||
  Rat   131 DASPSSIRILKSDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPR 195

  Fly   191 KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPG 255
            |||.:|||||||||||:||||||||||||||||||||||.||.||:|||:||:|||.||::||||
  Rat   196 KCNMDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPG 260

  Fly   256 NRVLIQGIYSIRKVG-KPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHF 319
            |||.|.|||||:|.| .||:  ||::..||:|:.|:||:||.||::|:|. |...:::..|||.|
  Rat   261 NRVTIMGIYSIKKFGMNPSK--GRDRVGVGIRSSYIRVLGIQVDTDGSGR-SFAGSVSPQEEEEF 322

  Fly   320 RRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAK 384
            ||:||..:|||.:|:|::|||||..|:||||.|:|||||||||||||.||||||:|:||||||||
  Rat   323 RRLAALPNIYELVSRSVSPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAK 387

  Fly   385 SQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRE 449
            |||||||||.:||.|||||||||||||||||::||.:|||:||||||||||||||||||||||||
  Rat   388 SQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRE 452

  Fly   450 DDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMI 514
            ||||||||||||||||||||||||||||||||||||||:|||||:||||:|||||||||||||||
  Rat   453 DDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMI 517

  Fly   515 FIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGE 579
            |||||.|:|.||:.||||:|.:|:|:  ...::..||||.|:..||:|.|||..||||||..|.|
  Rat   518 FIVKDEHNEERDMMLAKHVITLHVSA--LTQTQAVEGEIDLAKMKKFIAYCRARCGPRLSAEAAE 580

  Fly   580 KLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQ 644
            |||:||::|||||.|.|:..|:|.|||||||||||::||:|:|:|::||||||:..|.|||||||
  Rat   581 KLKNRYIIMRSGARQHERDIDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQ 645

  Fly   645 VSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMK 709
            |||||||::|:|:|.|||||:||||.|:||||||||||||||||||.:|:|||.:|||.|..:.|
  Rat   646 VSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIVQDFTKQKYPEHAIRK 710

  Fly   710 VIHTMIRRGELQHRMQRKMLYRI 732
            |:..|:||||:|||||||:|||:
  Rat   711 VLQLMLRRGEIQHRMQRKVLYRL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	52/96 (54%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	373/520 (72%)
Mcm5	XP_038953490.1	MCM_N	32..129	CDD:405270	55/100 (55%)
Mcm5	XP_038953490.1	MCM	133..649	CDD:214631	372/516 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353446
Domainoid	1	1.000	376	1.000	Domainoid score	I831
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4904
Inparanoid	1	1.050	1015	1.000	Inparanoid score	I267
OMA	1	1.010	-	-		QHG53983
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	1	1.000	-	-		FOG0004690
OrthoInspector	1	1.000	-	-		oto95761
orthoMCL	1	0.900	-	-		OOG6_102165
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810