DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and Mcm7

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001004203.3	Gene:	Mcm7 / 288532	RGDID:	1303018	Length:	719	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	236/754 - (31%)
Similarity:	380/754 - (50%)	Gaps:	128/754 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KKKYKEFIRTFNEENFF----YKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHL 91
            |:|.|:|::.|..::..    :||...|.......:..|.::::|:...|..|.|.:.:....:.
  Rat    10 KEKVKKFLQEFYYDDELGKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYS 74

  Fly    92 EIFEEAAREVADE-------------------------------ITAPRPEH-EEHMHDIQILLS 124
            .:|.:..:|:..|                               :..|:.:: .|.|...::...
  Rat    75 RLFADVVQELLPEYKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFQ 139

  Fly   125 --SNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYA 187
              |::.|..||::::|.|.||:.:.||:...|.:..:....:..|..|           |.|.|.
  Rat   140 GPSSSKPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQC-----------GAETYQ 193

  Fly   188 -------LP------RKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRH 239
                   :|      ::|.|.::|      ...::.....|.:.||.:|:||..|.||.|.|||.
  Rat   194 PIQSPTFMPLIMCPSQECQTNRSG------GRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRS 252

  Fly   240 LQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRA-PYM---RVVGITV--- 297
            :.:..:........||:.|.:.||:      .|..|.|.::...|:.: .|:   |||.:|.
  Rat   253 ITVVLEGENTRIAQPGDHVSVTGIF------LPVLRTGFQQMAQGLLSETYLEAHRVVKMTKSED 311

  Fly   298 DSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL 362
            |..|||.:|         .|..:::|.. |.||:|:.|:||.|:|..|:|||:..:|.||. .:.
  Rat   312 DVSGAGELS---------AEELKQIAEE-DFYEKLAASIAPEIYGHEDVKKALLLLLVGGV-DQS 365

  Fly   363 PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVME 427
            |.|:..||:|::.|:||||.||||||.:::::||.:.||:|:|||..||||:|::|..:....:|
  Rat   366 PQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLE 430

  Fly   428 GGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRW 492
            |||:||||.||.||||||||.|.||.||||.|||||||||||||.||||:|||:|||||..:||:
  Rat   431 GGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRY 495

  Fly   493 DDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGE-ISL 555
            :..:. |:||.....:|||||::::::|..|...|:.||:||..||..|.:    .||:.| :.:
  Rat   496 NPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQ----PPAQFEPLDM 556

  Fly   556 STFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISE 620
            ...::||..||.. .|.:.::..:.:.:.||.||..|...:.|:      ..:.|.|.|::|:|.
  Rat   557 KLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDAT------YTSARTLLAILRLST 614

  Fly   621 SLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFT--TEEDQETLNRIEKQL----- 678
            :||::|:......|.||||:||.::|      ..||.|.:|.|  |:...:.:....::|
  Rat   615 ALARLRMVDIVEKEDVNEAIRLMEMS------KDSLLGEKGQTARTQRPADVIFATVRELVSGGR 673

  Fly   679 KRRFAIGSQVSEQNILQDF-------LRQKYEERTVMKV 710
            ..||   |:..::.|.:.|       ...:|||..|.:|
  Rat   674 SVRF---SEAEQRCISRGFTPAQFQAALDEYEELNVWQV 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	19/128 (15%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	199/541 (37%)
Mcm7	NP_001004203.3	MCM_N	12..165	CDD:291233	26/152 (17%)
		MCM	145..641	CDD:214631	199/546 (36%)
		P-loop_NTPase	376..515	CDD:304359	82/138 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820