DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm5 and MCM9

DIOPT Version :10

Sequence 1:NP_524308.2 Gene:Mcm5 / 41296 FlyBaseID:FBgn0017577 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_060166.2 Gene:MCM9 / 254394 HGNCID:21484 Length:1143 Species:Homo sapiens


Alignment Length:718 Identity:207/718 - (28%)
Similarity:345/718 - (48%) Gaps:90/718 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QINLQAVKKKYKEFIRTFNEEN--FFYKYRDTLKRNY---LNGRYFLEIEMEDLVGFDETLADKL 83
            |:.|  |.:.::.::..:::.:  ...|.||. ..:|   :|.....|..||        :.:..
Human     5 QVTL--VGQVFESYVSEYHKNDILLILKERDE-DAHYPVVVNAMTLFETNME--------IGEYF 58

  Fly    84 NKQPTEHLEIFEEAAREVADEI--TAPRPEHEEHMHDIQILLSS-NANPTNIRQ--LKSDCVSKL 143
            |..|:|.|.||:.|.|..|..|  :..:||......::...:|. ...|..:|:  .|:..|...
Human    59 NMFPSEVLTIFDSALRRSALTILQSLSQPEAVSMKQNLHARISGLPVCPELVREHIPKTKDVGHF 123

  Fly   144 VKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGY---ALPRKCNTEQAGRPKCPLD 205
            :.:.|.::..|.:..........|..|..|   ..:....|.|   ..|..|.:.::    |...
Human   124 LSVTGTVIRTSLVKVLEFERDYMCNKCKHV---FVIKADFEQYYTFCRPSSCPSLES----CDSS 181

  Fly   206 PFFIM------PDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIY 264
            .|..:      |.:|:  |:|.:|:||....:..|.|||.:::..:..|.:....|:.:.|.|| 
Human   182 KFTCLSGLSSSPTRCR--DYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI- 243

  Fly   265 SIRKVGKPSRRDGREKAVVGVRAPYMRV-----VGITVDSEGAGAISRYSNITSDEEEHFRRMAA 324
             :.:..||.::|.|.:..:.::|.|::|     .||.:|.|           ...|.|.|.....
Human   244 -VMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEE-----------VQKEFEDFWEYYK 296

  Fly   325 SGDIYER--LSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQL 387
            |.....|  :..||.|.:||...:|.|:..:|.||.::....|...||:.::||:|||||.|||.
Human   297 SDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQF 361

  Fly   388 LKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDR 452
            ||:..|:.|.:|.|:|.||::||||.:.:||....|  :|.||:||||.|:.|||||:.::|.||
Human   362 LKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWN--LEAGALVLADAGLCCIDEFNSLKEHDR 424

  Fly   453 VAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKG-EENIDFMPTILSRFDMIFI 516
            .:|||||||||||:||||:...||:|.::|||.|. .|::|..:. ..||.....:|||||:|.:
Human   425 TSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILV 488

  Fly   517 VKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKL 581
            :.|..:|..|     .||:..:..||..||: :|...|:...|.|....| :..|.||:...:.|
Human   489 LLDTKNEDWD-----RIISSFILENKGYPSK-SEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVL 546

  Fly   582 KSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVS 646
            ...|        |.::.||.|.:...|:|.||::||::|:.|::..:...|   :.:|:.:  ||
Human   547 LRYY--------QMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVT---LEDAITV--VS 598

  Fly   647 TLDAAMTGS--LAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMK 709
            .::::|.|.  |.|.....|...:....:.::|.:   .|..::..|::|.:.||:.  ||...:
Human   599 VMESSMQGGALLGGVNALHTSFPENPGEQYQRQCE---LILEKLELQSLLSEELRRL--ERLQNQ 658

  Fly   710 VIH 712
            .:|
Human   659 SVH 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm5NP_524308.2 MCM_N 31..125 CDD:464206 20/100 (20%)
MCM 128..648 CDD:214631 169/538 (31%)
MCM9NP_060166.2 Mcm2 2..605 CDD:440854 193/655 (29%)
MCM9 305..603 CDD:350666 122/320 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..738 1/6 (17%)
PTZ00449 <751..1113 CDD:185628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..815
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..916
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 942..1011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1063..1105
Blue background indicates that the domain is not in the aligned region.

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