Protein Alignment Mcm5 and mcm2

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_775364.2
• Gene: mcm2 / 192338
• ZFINID: ZDB-GENE-020419-24
• Length: 889
• Species: Danio rerio
• Alignment Length: 795
• Identity: 251/795 - (31%)
• Similarity: 400/795 - (50%)
• Gaps: 123/795 - (15%)

  Fly     1 MEGFDDAGVFFSDNFGGDNQQDAQ-------INLQA----VKKKYKEFIRTFNEEN----FFYKY 50
            |||.|:..:...:|.     :|.:       :::.|    :..::|.|:||..:|:    |..:.
Zfish   148 MEGEDEEMIESIENL-----EDMKGHTVREWVSMAAPRLEIYHRFKNFLRTHVDEHGHNVFKERI 207

  Fly    51 RDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEH 115
            .|..|.|    :..|.:..|:|...:..||..|.:.|.|.|:||:|||:||   :.|..|:::..
Zfish   208 SDMCKEN----KESLLVNYEELASREHVLAYFLPEAPAEMLKIFDEAAKEV---VLAMYPKYDRI 265

  Fly   116 MHDIQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVI------ 174
            .|:|.:.:.:......:|.|:...:::|::.:|::.:.:|:..:...:...|..|:.::
Zfish   266 AHEIHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFILGPFFQS 330

  Fly   175 PNLKVNPGLEGYALPRKCNTEQAGRPKC-PLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPR 238
            .|.:|.||        .|       |:| .|.||.|..::....::|.:.:||.|..|..|.:||
Zfish   331 QNQEVKPG--------SC-------PECQSLGPFEINMEQTVYQNYQRITIQESPGKVAAGRLPR 380

  Fly   239 HLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAG 303
            .........|.:...||:.:.:.|||.....|..:..:|     ..|.|..:....|....||..
Zfish   381 SKDAILLADLVDMCKPGDEIELTGIYHNNYDGSLNMANG-----FPVFATVILANHIARKDEGVA 440

  Fly   304 AISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCR 368
            .    :.:|.::.:....::....|.||:..|:.|||:...|||:.:...||||..|. |.|..:
Zfish   441 V----AELTDEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKN-PGGKHK 500

  Fly   369 -RGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMV 432
             ||||||||.|||||||||.||:|||||..||:|:|:|:||.||||.|.:.|.:|.:.:|.||:|
Zfish   501 VRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALV 565

  Fly   433 LADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDT-K 496
            |||.||..|||||||.:.||.:||||||||:|||:||||.|:|.:||:|:||||.|.||:|.: .
Zfish   566 LADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLT 630

  Fly   497 GEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLS---SNKSAPSEPAEGEISLSTF 558
            ..||:|....|:||||::.:|:|..|..:|..||:.::..|:.   |||.......|..:..:||
Zfish   631 FSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIKHHPSNKEGGVAGLEEVVLPNTF 695

  Fly   559 ----------KKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLE 613
                      :|||.|.:....|:|::...:|:...|..:|       |.|....|||||||.:|
Zfish   696 DVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLR-------KESMATGSIPITVRHIE 753

  Fly   614 AVIRISESLAKIRLQPFATDEHVNEALRLFQVSTLDA-------AMTGSLAGAEGFTTEEDQETL 671
            ::||::|:.|::.|:.:..::.||.|:|:...|.:|.       :|..:.|....| ..::.|.|
Zfish   754 SMIRMAEAHARMHLRDYVLEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLAF-RRDNNELL 817

  Fly   672 NRIEKQLKRRFAIGSQVSEQNILQDFLRQKY----------EERTVMKV----IHT--------M 714
            ..|.|||     :..|||.|       |.:|          |:..|.|.    ||:        :
Zfish   818 LFILKQL-----VSEQVSYQ-------RNRYGAQQDTIEIAEKDLVDKARQINIHSLSAFYDSDL 870

  Fly   715 IRRGELQHRMQRKML 729
            .|..:..|.:::|::
Zfish   871 FRSNKFSHDVKKKLI 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	29/97 (30%)
		MCM	128..648	CDD:214631	191/541 (35%)
mcm2	NP_775364.2	MCM2_N	57..170	CDD:403724	6/26 (23%)
		MCM_N	185..273	CDD:464206	29/94 (31%)
		MCM	279..788	CDD:214631	191/540 (35%)