Protein Alignment Mcm5 and mcm7

DIOPT Version :10

• Sequence 1: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: NP_997734.1
• Gene: mcm7 / 192333
• ZFINID: ZDB-GENE-020419-27
• Length: 721
• Species: Danio rerio
• Alignment Length: 749
• Identity: 233/749 - (31%)
• Similarity: 358/749 - (47%)
• Gaps: 152/749 - (20%)

  Fly    29 AVKKKYKEFIRTFNEEN----FFYKYRDTLKRNYLNGRYFLEIEMEDLVGFDETLADKLNKQPTE 89
            |.|:|.|.|::.|..|:    ..:||...|.......:..|.::::|:...|..|.:.:.:....
Zfish     8 AEKEKCKRFLQEFYTEDDSGKKIFKYGAQLVSLAHREQVALLVDLDDVAEEDPDLVESVCENAKR 72

  Fly    90 HLEIFEEAAREVADEI---------------------------TAPRPEHE-----EHMHDIQIL 122
            :..:|.:|..|:..|.                           .|...:|.     |.|...::.
Zfish    73 YTALFADAIHELLPEYREREAVVKDALDVYIEHRLMMEVRGRDPADTRDHRKQYPPELMRRFEVY 137

  Fly   123 LSSNA--NPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEG 185
            ....|  .|..:|.:|:|.:.:||.:.||:..|:.:.......:..|..|           |.|.
Zfish   138 FRPPATLKPRVVRDVKADSIGQLVTVRGIVTRATEVKPMMAVATYTCDQC-----------GAET 191

  Fly   186 Y---ALP----------RKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIP 237
            |   |.|          ::|.|.::|      ...::.....|.:.||.|::||..|.||.|.||
Zfish   192 YQPIASPSFTPLIMCPSQECVTNKSG------GRLYLQTRGSKFIKFQELRIQEHSDQVPVGNIP 250

  Fly   238 RHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRA-PYMRVVGITVDSEG 301
            |.:.::..........||:.|.:.|::      .|..|.|..:||.|:.: .|:....||:
Zfish   251 RSMTIYARGENTRVAQPGDHVAVSGVF------LPLLRSGFRQAVQGLLSETYLECHSITL---- 305

  Fly   302 AGAISRYSNITSDEE--------EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGS 358
                   .|.|.|:|        |..|::... |.||:|:.|:||.|:|..|:|||:..:|.||.
Zfish   306 -------MNKTEDDELGTEELSDEELRQITEE-DFYEKLAGSIAPEIYGHEDVKKALLLLLVGGV 362

  Fly   359 RKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRN 423
             ::.|.|:..||:||:.|:||||.||||||.:::::||.:.||:|:|||..||||:||:||.|..
Zfish   363 -EQAPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVMRDPVTGE 426

  Fly   424 FVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSI 488
            ..:||||:||||.||.||||||||.:.||.||||.|||||||||||||.|:||:|||:|||||..
Zfish   427 MTLEGGALVLADLGVCCIDEFDKMADADRTAIHEVMEQQTISIAKAGIMTSLNARCSILAAANPA 491

  Fly   489 FGRWDDTKG-EENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLSSNKSAPSE--PAE 550
            :||::..|. |:||.....:|||||::::::|..|...|:.||:||..|| ...:..|:.  |
Zfish   492 YGRYNPRKSIEQNIQLPAALLSRFDLLWLIQDRPDAESDLRLAQHITYVH-QHCRQPPTHFTP-- 553

  Fly   551 GEISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPIT---VRQL 612
              |.:...::||..|:.. .|.:.|:..:.:.:.||.||..|         |:|...|   .|.|
Zfish   554 --IDMKLMRRYISKCKQK-QPVVPESLSDYITAAYVEMRKEA---------RVSKDTTFTSARTL 606

  Fly   613 EAVIRISESLAKIRLQPFATDEHVNEALRLFQVS----------------------TLDAAMTGS 655
            .:::|:|.:||::|:......|.||||:||.::|                      :|...:.|.
Zfish   607 LSILRLSTALARLRMVSVVEKEDVNEAMRLMEMSKDSLQADRSSSSRAQRPADVIFSLLRELCGE 671

  Fly   656 LAG-------------AEGFTTEEDQETLNRIEK 676
            .||             :.|||..:.|..|...|:
Zfish   672 SAGRSVRVSAAEQRCVSRGFTPAQFQAALQEYEE 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	21/129 (16%)
		MCM	128..648	CDD:214631	200/569 (35%)
mcm7	NP_997734.1	MCM_N	10..103	CDD:464206	17/92 (18%)
		MCM	145..641	CDD:475121	199/546 (36%)