DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm5 and mcm3

DIOPT Version :9

Sequence 1:	NP_524308.2	Gene:	Mcm5 / 41296	FlyBaseID:	FBgn0017577	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_997732.2	Gene:	mcm3 / 192323	ZFINID:	ZDB-GENE-020419-4	Length:	807	Species:	Danio rerio

Alignment Length:	743	Identity:	229/743 - (30%)
Similarity:	353/743 - (47%)	Gaps:	104/743 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DNQQDAQINLQAVKKKYKEFIRTFNEENFFY-KYRDTLKRNYLNGRYFLEIEMEDLVGFDETLAD 81
            |:|:     ::..::.|.:|:....::..:. |.|..:..|    :..|.:.:.||...:|..|.
Zfish     7 DDQE-----MREAQRDYLDFLDDDQDQGIYQSKVRQMISEN----KSRLIVNLNDLRRRNEKRAA 62

  Fly    82 KLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSSNANPTNIRQLKSDCVSKLVKI 146
            ||.....|.|..|:.|.:::...|.|...:..|... |.:..|..:...:.|.|.|..:..:|.:
Zfish    63 KLLNNAFEELLAFQRALKDLVASIDATYAKQCEEFF-IGLEGSFGSKHVSPRTLTSRLLGSMVCL 126

  Fly   147 AGIIVAASGISAKATRMSIQCLSCS-------TVIPNLKVNPGLEGYALPRKCNTEQAGRPKCPL 204
            .||:...|.:..|..|....|.:..       |.:.:|...|....|....:.|.        ||
Zfish   127 EGIVTKCSLVRPKVVRSVHYCPATKKTMERKYTDLTSLDAFPSSAIYPTKDEENN--------PL 183

  Fly   205 DPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKV 269
            :..|.:   ....|.||:.:||:|:..|.|::||.:.:..|..|.:.|.||:|..:.|.|..
Zfish   184 ETEFGL---SVYKDHQTITIQEMPEKAPAGQLPRSVDIILDNDLVDAVKPGDRTQVIGTYRC--- 242

  Fly   270 GKPSRRDGREKAVVGVRAPYMRVVGITVD-SEGAGAISRYSNITSDEEEHFRRM--AASGDIYER 331
             .|.::.|.....       .|.:.|... .:.:..||.|  .::|:....:..  :.|.:::::
Zfish   243 -LPGKKGGFTSGT-------FRTIMIACHVKQMSKEISHY--FSADDVAKIKSFCRSRSKNVFDQ 297

  Fly   332 LSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAP 396
            |::||||||.|...|||||.|||.||..|.|.:|...||||||||:|||..||||||::|...||
Zfish   298 LARSLAPSIHGHEYIKKAILCMLLGGVEKVLENGSRIRGDINVLLIGDPSVAKSQLLRYVLHTAP 362

  Fly   397 IAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQ 461
            .|:.|:|:|||..||||:|..|.:|....:|.|||||.|.|||||||||||.:.||.||||.|||
Zfish   363 RAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLGDRGVVCIDEFDKMSDMDRTAIHEVMEQ 427

  Fly   462 QTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGE-ENIDFMPTILSRFDMIFIVKDIHDESR 525
            ..::||||||...||:|||||||||.::||:|..|.. |||....::|||||::||:.|..|..:
Zfish   428 GRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQ 492

  Fly   526 DITLAKHIINVH---------------------LSSNKSAPSEPAEGE----------------- 552
            |..::.|::.:|                     |::.....::..|.|
Zfish   493 DREISDHVLRMHRYRDPHEQDGTALALGGTIDALATEDPDATQEEEEELQVYEKHNPLLHGSKKN 557

  Fly   553 ----ISLSTFKKYIHYCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLE 613
                :|.:..:||||..:. ..|.|::.|...:...|..:|:   |::..||...:.|:|.|.||
Zfish   558 KDRVVSKAFMRKYIHVAKA-ISPVLTQDAANHIAEEYSRLRN---QEQLGSDIARTSPVTARTLE 618

  Fly   614 AVIRISESLAKIRLQPFATDEHVNEALRLFQVS----TLDAAMTGSLAGAEGFTTEEDQETLNRI 674
            .:||:|.:.||.|:...........|:.|.|.:    .|:.....|..|.:...:|:::|..:..
Zfish   619 TLIRLSTAHAKARMSKAVELVDTEVAVELVQFAYFKKVLEKERKRSRNGQQDAASEDEEEEEDEA 683

  Fly   675 E-----KQLKRRFAIGSQVSEQNILQDF 697
            :     .:.:||   |||.||.....||
Zfish   684 QDTPRPPRKRRR---GSQGSESYDPYDF 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm5	NP_524308.2	MCM_N	31..124	CDD:405270	20/93 (22%)
Mcm5	NP_524308.2	MCM	128..648	CDD:214631	192/576 (33%)
mcm3	NP_997732.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820